P
Poul Henning Jensen
Researcher at Aarhus University
Publications - 157
Citations - 10171
Poul Henning Jensen is an academic researcher from Aarhus University. The author has contributed to research in topics: Alpha-synuclein & Synucleinopathies. The author has an hindex of 50, co-authored 145 publications receiving 8728 citations. Previous affiliations of Poul Henning Jensen include Aalborg University & Max Planck Society.
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Structural and functional characterization of two alpha-synuclein strains
Luc Bousset,Laura Pieri,Gemma Ruiz-Arlandis,Julia Gath,Poul Henning Jensen,Birgit Habenstein,Karine Madiona,Vincent Olieric,Anja Böckmann,Beat H. Meier,Ronald Melki +10 more
TL;DR: It is shown that the two strains of α-synuclein have different structures, levels of toxicity, and in vitro and in vivo seeding and propagation properties, which may account for differences in disease progression in different individuals/cell types and/or types of synucleinopathies.
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DJ-1 and α-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease
Zhen Hong,Min Shi,Kathryn A. Chung,Joseph F. Quinn,Elaine R. Peskind,Douglas Galasko,Joseph Jankovic,Cyrus P. Zabetian,James B. Leverenz,Geoffrey S. Baird,Thomas J. Montine,Aneeka M. Hancock,Hyejin Hwang,Catherine Pan,Joshua M. Bradner,Un Jung Kang,Poul Henning Jensen,Jing Zhang +17 more
TL;DR: It is demonstrated that total DJ-1 and alpha-synuclein in human cerebrospinal fluid are helpful diagnostic markers for Parkinson's disease, if variables such as blood contamination and age are taken into consideration.
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Purified alpha 2-macroglobulin receptor/LDL receptor-related protein binds urokinase.plasminogen activator inhibitor type-1 complex. Evidence that the alpha 2-macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes.
Anders Nykjaer,Claus Munck Petersen,Bjarne Kuno Møller,Poul Henning Jensen,S K Moestrup,Thor Las Holtet,Michael Etzerodt,Hans Christian Thøgersen,Mette Munch,Peter A. Andreasen +9 more
TL;DR: PAI-1, like uPA and its amino-terminal fragment, bound to the urokinase receptor (uPAR), and the inhibitor-enhanced uPA degradation was blocked by r alpha 2MRAP and inhibited by polyclonal anti-alpha 2MR/LRP antibodies, taken as evidence for mediation of internalization and degradation of uPAR-bound uPA.
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α-Synuclein Binds to Tau and Stimulates the Protein Kinase A-catalyzed Tau Phosphorylation of Serine Residues 262 and 356
TL;DR: It is proposed that α-synuclein modulates the phosphorylation of soluble axonal tau and thereby indirectly affects the stability of axonal microtubules.
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Proteasomal Inhibition by α-Synuclein Filaments and Oligomers
Evo Lindersson,Rasmus Beedholm,Peter Højrup,Torben Moos,Wei Ping Gai,Klavs B. Hendil,Poul Henning Jensen +6 more
TL;DR: It is demonstrated that α-synuclein and 20 S proteasome components co-localize in Lewy bodies and that subunits from 20 S Proteasome particles, in contrast to subunits of the 19 S regulatory complex, bind efficiently to aggregated filamentous but not monomeric α- synuclein.