P
Poupart Marc-Andre
Researcher at Boehringer Ingelheim
Publications - 7
Citations - 900
Poupart Marc-Andre is an academic researcher from Boehringer Ingelheim. The author has contributed to research in topics: Tripeptide & Enantiomer. The author has an hindex of 2, co-authored 7 publications receiving 855 citations.
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Journal ArticleDOI
Cleavage of Cohesin by the CD Clan Protease Separin Triggers Anaphase in Yeast
TL;DR: It is shown here that separin is a cysteine protease related to caspases that alone can cleave Sccl in vitro and depends on a conserved protein called separin for sister chromatid separation.
Patent
Hepatitis c virus ns5b polymerase inhibitor binding pocket
Coulombe Rene,Pierre L. Beaulieu,Eric Jolicoeur,George Kukolj,Steven R. LaPlante,Poupart Marc-Andre +5 more
TL;DR: In this article, the HCV NS5B polymerase adopts a confirmation in which the finger loop region defined by amino acid residues 18 to 35 is displaced to expose a binding pocket defined generally by amino acids residues 392, 393, 395, 396, 399, 424, 425, 428, 429, 492, 493, 494, 495, 496, 500 and 503.
Patent
Tripeptides, method for their production, pharmaceutical preparation containing the same, their use and intermediates
Llinas-Brunet Montse,Bailey Murray D,Dale R. Cameron,Faucher Anne-Marie,Ghiro Elise,Goudreau Nathalie,Halmos Teddy,Poupart Marc-Andre,Rancourt Jean,Youla S. Tsantrizos,Dominik Wernic +10 more
TL;DR: In this article, the use of the same method for the preparation of a medicament for treating hepatitis C viral infection was discussed. But the present invention relates to racemates, diastereoisomers and optical isomers of tripeptides of general formula.
Patent
Peptide inhibitors of hepatitis C virus
Llinas-Brunet Montse,Bailey Murray D,Dale R. Cameron,Faucher Anne-Marie,Ghiro Elise,Goudreau Nathalie,Halmos Teddy,Poupart Marc-Andre,Rancourt Jean,Youla S. Tsantrizos,Dominik Wernic +10 more
TL;DR: In this paper, the use of the compounds of the general formula I for preparing a medicament intended for the United States was discussed. But the use was limited to the preparation of a medicine.
Patent
Hepatitis c tripeptide inhibitoren
Llinas-Brunet Montse,Bailey Murray D,Dale R. Cameron,Faucher Anne-Marie,Ghiro Elise,Goudreau Nathalie,Halmos Teddy,Poupart Marc-Andre,Rancourt Jean,Youla S. Tsantrizos,Dominik Wernic,Bruno Simoneau +11 more
TL;DR: In this article, an acyl derivative of formula R 4 -O-C(O)-(O), an amide of formula 4 -N(R 5 )-C (O)-; a thioamide of the same type of formula, and a sulfonyl of the form R 4-SO 2 -C(SO 2 ).