P
Pratap Singhasivanon
Researcher at Mahidol University
Publications - 224
Citations - 13661
Pratap Singhasivanon is an academic researcher from Mahidol University. The author has contributed to research in topics: Malaria & Population. The author has an hindex of 53, co-authored 222 publications receiving 12629 citations. Previous affiliations of Pratap Singhasivanon include French Institute of Health and Medical Research & Liverpool John Moores University.
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Journal ArticleDOI
Artemisinin Resistance in Plasmodium falciparum Malaria
Arjen M. Dondorp,François Nosten,Poravuth Yi,Debashish Das,Aung Phae Phyo,Joel Tarning,Khin Maung Lwin,Frédéric Ariey,Warunee Hanpithakpong,Sue J. Lee,Pascal Ringwald,Kamolrat Silamut,Mallika Imwong,Kesinee Chotivanich,Pharath Lim,Trent Herdman,Sen Sam An,Shunmay Yeung,Pratap Singhasivanon,Nicholas P. J. Day,Niklas Lindegardh,Duong Socheat,Nicholas J. White +22 more
TL;DR: The overall median clearance times were 84 hours (interquartile range, 60 to 96) in Pailin and 48 hours in Wang Pha (P<0.001) in each of the two locations as discussed by the authors.
Journal ArticleDOI
Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study
Aung Pyae Phyo,Standwell Nkhoma,Kasia Stepniewska,Kasia Stepniewska,Elizabeth A. Ashley,Elizabeth A. Ashley,Shalini Nair,Rose McGready,Rose McGready,Carit Ler Moo,Salma Al-Saai,Arjen M. Dondorp,Arjen M. Dondorp,Khin Maung Lwin,Pratap Singhasivanon,Nicholas P. J. Day,Nicholas P. J. Day,Nicholas J. White,Nicholas J. White,Tim J. Anderson,François Nosten,François Nosten +21 more
TL;DR: Genetically determined artemisinin resistance in P falciparum emerged along the Thailand–Myanmar border at least 8 years ago and has since increased substantially, with experts predicting resistance will reach rates reported in western Cambodia in 2–6 years.
Journal ArticleDOI
Genome-wide and fine-resolution association analysis of malaria in West Africa
Muminatou Jallow,Yik Ying Teo,Yik Ying Teo,Kerrin S. Small,Kerrin S. Small,Kirk A. Rockett,Kirk A. Rockett,Panos Deloukas,Taane G. Clark,Taane G. Clark,Katja Kivinen,Kalifa Bojang,David J. Conway,Margaret Pinder,Giorgio Sirugo,Fatou Sisay-Joof,Stanley Usen,Sarah Auburn,Sarah Auburn,Suzannah Bumpstead,Susana Campino,Susana Campino,Alison J. Coffey,Andrew Dunham,Andrew E. Fry,Angela Green,Rhian Gwilliam,Sarah E. Hunt,Michael Inouye,Anna E. Jeffreys,Alieu Mendy,Aarno Palotie,Simon C. Potter,Jiannis Ragoussis,Jane Rogers,Kate Rowlands,Elilan Somaskantharajah,Pamela Whittaker,Claire Widden,Peter Donnelly,Bryan Howie,Jonathan Marchini,Andrew P. Morris,Miguel A. Sanjoaquin,Miguel A. Sanjoaquin,Eric A. Achidi,Tsiri Agbenyega,Angela Allen,Angela Allen,Olukemi K. Amodu,Patrick H. Corran,Abdoulaye A. Djimde,Amagana Dolo,Ogobara K. Doumbo,Chris Drakeley,Sarah J. Dunstan,Jennifer Evans,Jennifer Evans,Jeremy Farrar,Deepika Fernando,Tran Tinh Hien,Rolf D. Horstmann,Muntaser E. Ibrahim,Nadira D. Karunaweera,Gilbert Kokwaro,Kwadwo A. Koram,Martha M. Lemnge,Julie Makani,Kevin Marsh,Pascal Michon,David Modiano,Malcolm E. Molyneux,Ivo Mueller,Michael Parker,Norbert Peshu,Christopher V. Plowe,Odile Puijalon,John C. Reeder,Hugh Reyburn,Eleanor M. Riley,Anavaj Sakuntabhai,Pratap Singhasivanon,Sodiomon B. Sirima,Adama Tall,Terrie E. Taylor,Mahamadou A. Thera,Marita Troye-Blomberg,Thomas N. Williams,Michael T. Wilson,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski +90 more
TL;DR: These findings provide proof of principle that fine-resolution multipoint imputation, based on population-specific sequencing data, can substantially boost authentic GWA signals and enable fine mapping of causal variants in African populations.
Journal ArticleDOI
Molecular and Pharmacological Determinants of the Therapeutic Response to Artemether-Lumefantrine in Multidrug-Resistant Plasmodium falciparum Malaria
Ric N. Price,Ric N. Price,Anne-Catrin Uhlemann,Michèle van Vugt,Al Brockman,Robert Hutagalung,Shalini Nair,Denae Nash,Pratap Singhasivanon,Tim J. Anderson,Sanjeev Krishna,Nicholas J. White,Nicholas J. White,François Nosten,François Nosten +14 more
TL;DR: The lumefantrine plasma concentration profile is the main determinant of efficacy of artemether-lumefanrine in patients with uncomplicated Plasmodium falciparum malaria and, therefore, treatment responses when plasma lumfantrine levels are subtherapeutic.
Journal ArticleDOI
Changes in the Treatment Responses to Artesunate-Mefloquine on the Northwestern Border of Thailand during 13 Years of Continuous Deployment
Verena I. Carrara,Julien Zwang,Elizabeth A. Ashley,Elizabeth A. Ashley,Ric N. Price,Ric N. Price,Kasia Stepniewska,Kasia Stepniewska,Marion Barends,Alan Brockman,Tim J. Anderson,Rose McGready,Rose McGready,Lucy Phaiphun,Stephane Proux,Michèle van Vugt,Robert Hutagalung,Khin Maung Lwin,Aung Pyae Phyo,Piyanuch Preechapornkul,Mallika Imwong,Sasithon Pukrittayakamee,Pratap Singhasivanon,Nicholas J. White,Nicholas J. White,François Nosten,François Nosten +26 more
TL;DR: Artesunate-mefloquine remains a highly efficacious antimalarial treatment in this area despite 13 years of widespread intense deployment, but there is evidence of a modest increase in resistance.