/pdf/identification-of-potential-inhibitors-against-sars-cov-2-by-2x0mp2fxpg.pdf

Identification of potential inhibitors against SARS-CoV-2 by targeting proteins responsible for envelope formation and virion assembly using docking based virtual screening, and pharmacokinetics approaches.

Neglected tropical diseases (NTDs) as termed by WHO include twenty different infectious diseases that are caused by bacteria, viruses, and parasites. Among these NTDs, Chagas disease and leishmaniasis are reported to cause high mortality in humans and are further associated with the limitations of existing drugs like severe toxicity and drug resistance. The above hitches have rendered researchers to focus on developing alternatives and novel therapeutics for the treatment of these diseases. In the past decade, several target-based drugs have emerged, which focus on specific biochemical pathways of the causative parasites. For leishmaniasis, the targets such as nucleoside analogs, inhibitors targeting nucleoside phosphate kinases of the parasite's purine salvage pathway, 20S proteasome of Leishmania, mitochondria, and the associated proteins are reviewed along with the chemical structures of potential drug candidates. Similarly, in case of therapeutics for Chagas disease, several target-based drug candidates targeting sterol biosynthetic pathway (C14-ademethylase), L-cysteine protease, heme peroxidation, mitochondria, farnesyl pyrophosphate, etc., which are vital and unique to the causative parasite are discussed. Moreover, the use of nano-based formulations towards the therapeutics of the above diseases is also discussed.

/pdf/an-overview-on-the-therapeutics-of-neglected-infectious-4ip388ln2u.pdf

An Overview on the Therapeutics of Neglected Infectious Diseases—Leishmaniasis and Chagas Diseases

Evaluation of Flavonoids as 2019-nCoV Cell Entry Inhibitor Through Molecular Docking and Pharmacological Analysis

Perspectives of the Artemisia annua Dry Leaf Therapy (ALT) for Malaria and of its Re-Purposement as An Affordable Cure for ArtemisininTreatable Illnesses RICHA GOEL, RAJ KUMARI, VIJENDER SINGH, RICHA PANDEY, RENU KUMARI, SUCHI SRIVASTAVA and SUSHIL KUMAR Department of Pharmacognosy, KIET School of Pharmacy, Ghaziabad 201 206, India Department of Pharmacognosy, ITS College of Pharmacy, Ghaziabad 201 206, India School of Pharmacy, Sharda University, Greater Noida, Ghaziabad 201 306, India Division of Natural Product Chemistry, CSIR-Indian Institute of Chemical Technology (IICT), Uppal Road, Tarnaka, Hyderabad 500 001, India National Institute of Plant Genome Research (NIPGR), Aruna Asaf Ali Marg, New Delhi 110 067, India Division of Plant Microbe Interactions, CSIR-National Botanical Research Institute (NBRI), Lucknow 226 001, India SKA Institution for Research, Education and Development, 4/11 Sarv Priya Vihar, New Delhi 110 016, India

/pdf/perspectives-of-the-artemisia-annua-dry-leaf-therapy-alt-for-4zosi3g2u8.pdf

Perspectives of the Artemisia annua Dry Leaf Therapy (ALT) for Malaria and of its Re-Purposement as An Affordable Cure for ArtemisininTreatable Illnesses

"Identification of Nafamostat and VR23 as COVID-19 drug candidates by targeting 3CL pro and PL pro ."

Leishmania donovani, causes leishmaniasis, a global health trouble with around 89 different countries and its population under its risk. Replication initiation events have been instrumental in regu...

Evaluation of potential drugs against leishmaniasis targeting catalytic subunit of Leishmania donovani nuclear DNA primase using ligand based virtual screening, docking and molecular dynamics approaches.

Irrespective of various efforts, malaria persist the most debilitating effect in terms of morbidity and mortality. Moreover, the existing drugs are also vulnerable to the emergence of drug resistance. In order to explore the potential targets for designing the most effective anti-malarial therapies, it is required to focus on the facts of biochemical mechanism underlying the process of parasite survival and disease pathogenesis. This review is intended to bring out the existing knowledge about the functions and components of the major signaling pathways such as kinase signaling, calcium signaling, cyclic nucleotide based signaling, serving the various aspects of the parasitic asexual stage and highlighted the Toll like receptors (TLR), GPI (Glycosylphosphatidylinositol) mediated signaling and molecular events in cyto-adhesion which elicit the host immune response. This discussion will facilitate a look over essential components for parasite survival and disease progression to be implemented in discovery of novel anti-malarial drugs and vaccines.

/pdf/signaling-strategies-of-malaria-parasite-for-its-survival-2gs1wd9t8k.pdf

Signaling Strategies of Malaria Parasite for Its Survival, Proliferation, and Infection during Erythrocytic Stage.

Malaria has been present since ancient time and remains a major global health problem in developing countries. Plasmodium falciparum belongs to the phylum Apicomplexan, largely contain disease-causing parasites and characterized by the presence of apicoplast. It is a very essential organelle of P. falciparum responsible for the synthesis of key molecules required for the growth of the parasite. Indispensable nature of apicoplast makes it a potential drug target. Calcium signaling is important in the establishment of malaria parasite inside the host. It has been involved in invasion and egress of merozoites during the asexual life cycle of the parasite. Calcium signaling also regulates apicoplast metabolism. Therefore, in this review, we will focus on the role of apicoplast in malaria biology and its metabolic regulation through Ca++ signaling.

Plasmodium falciparum apicoplast and its transcriptional regulation through calcium signaling.

Relict plastidic metabolic process as a potential therapeutic target.

Visceral leishmaniasis is a neglected tropical disease and is mainly caused by L. donovani in the Indian subcontinent. The mitochondria genome replication in Leishmania spp. is having a very specif...

Praveen Rai

Papers

Evaluation of potential drugs against leishmaniasis targeting catalytic subunit of Leishmania donovani nuclear DNA primase using ligand based virtual screening, docking and molecular dynamics approaches.

Signaling Strategies of Malaria Parasite for Its Survival, Proliferation, and Infection during Erythrocytic Stage.

Plasmodium falciparum apicoplast and its transcriptional regulation through calcium signaling.

Relict plastidic metabolic process as a potential therapeutic target.

Drug repurposing based novel anti-leishmanial drug screening using in-silico and in-vitro approaches