Preethika Immaculate Britto

Bio: Preethika Immaculate Britto is an academic researcher from King Faisal University. The author has contributed to research in topics: Population & Gait (human). The author has an hindex of 1, co-authored 14 publications receiving 6 citations. Previous affiliations of Preethika Immaculate Britto include VIT University.

A Literature Review: To predict the Problem of Post Analysis in Breast Cancer Determination using the Wearable Device

Abstract: Cancer is one of the life threatening and painful disease, especially breast cancer is most aching disease for women. Statistics says that all over the world for every year 42,260 deaths are due to breast cancer. The major cause of death is late diagnosis. All around the globe mammogram is the standard diagnosing technique which is used, but the diagnosing process was bit difficult and seems painful. Later, wearable diagnosis device were implemented but due to air-gaps that was not so successful. So, in this project our aim is to over come the drawbacks in wearable device. This can be achieved by the help of microwave sensors and controllers. The technique we are going to use for diagnosing is image processing. Also this would be a comfortable and cost effective wearable device which can be conveniently used as breast cancer monitoring technique.

Design of IoT based Health Care Monitoring Systems using Raspberry Pi: A Review of the Latest Technologies and Limitations

Abstract: Information and communication technology has advanced in recent days, which has lead to the emergenceof Internet of Things (IoT). The healthcare monitoring system is widely used for various purposes in the current scenario. The fetal measurement and fetal diagnosing can be done using Internet of Things based Health Care Monitoring Systems. An accelerometer sensor can only measure the outside movement of the body and it is not able to measure internal body movements. The measurement can be done only in one, two and three orthogonal axes (3D direction). An accelerometer sensor can be used for fetal movement measurement by only giving a high-frequency range. When the high frequency is given, the object should be at rest to control the resting condition, it shouldn’t move at least for one inch. The fetal movement can be only done in the month of 9th or 10th month. The vibration of fetal heartbeat can be noticed. But the proper output is not obtained practically yet. This paper discuss the work related to appropriate selection of the sensor and programming which provides accurate movement of the fetal and the distance. The newly developed equipment with ultrasound sensor and proximity sensor are used to identify the distance of fetus and mother skin and the size of the fetus, respectively. All these can be measured during the every month of pregnancy. With the support of raspberry Pi, the general working functions of the equipment can improve the speed of the output. The expected conclusion is an ideal ultrasound sensor programmed with raspberry pi which determines/predicts the working function of fetus, and can be so called as fetus monitoring system.

A Retractive Approach for Postural Instability in Geriatric Population

Abstract: Stability is one of the most important human activities during walking. However, elderly people with movement disorders such as loss of muscle strength reduced the joint movement and stability have high risk of falling accidents during walking [1]. Fall is a major cause of problems in many countries. There are many existing solutions to overcome this and the statistical studies shows a better solution is needed for the same. Our work was mainly focused on the balance loss performed by the shoe which makes the stability to retain their balance.[2]. Balancing insole should be worn on both the legs, depending on the fall conditions is brought back to the normal position. . An accelerometer is used to detect the imbalance position, which is fed input to the microcontroller. The microcontroller is programmed in such a way that it runs the motor, which rotates the motion devices that are fixed to it, to retain the balance. Thus the motion devices finally move the leg to which the corresponding Insole is worn providing stability to the subject, hence overcoming the fall.

Medical Device to Tackle Neurogenic Bladder

Abstract: Almost one in twenty adults experience urinary incontinence problems according to major test surveys across all the populations irrespective of geography, cultures or backgrounds (Source: rightdiagnosis.com on 9th March 2015). While most of us take the blessing of voluntary voiding of our urinary bladder as a given, there are patients around the world who are not sensitive to the filling up of their bladder or its involuntary leakage. Thus, incontinence has a major impact on the quality of all patients leading to stress and embarrassment apart from other biological problems such as Urinary Tract Infections. Thus, to tackle this problem we have devised an innovative device that not only helps the patient concerned to track how much his/her bladder has filled up, but also helps in voluntary emptying of the same. The device, hence, has three major components, namely: 1) The sensor, 2) The Display and 3) The Micturition Control.

ScenarIoT: support for scenario specification of internet of things-based software systems

Abstract: Internet of Things (IoT) e um paradigma que permite compor sistemas a partir de objetos equipados com comportamentos de identificacao, sensoriamento ou atuacao alem de capacidades de processamento, os quais podem se comunicar e cooperar para alcancar objetivos. Assim como toda mudanca de paradigma, IoT faz emergir desafios relacionados a diversas areas de pesquisa, incluindo a Engenharia de Software nas diferentes fases de desenvolvimento. Considerando fases iniciais de projeto, este trabalho propoe a abordagem ScenarIoT visando apoiar a especificacao de cenarios no desenvolvimento de sistemas de software baseados em IoT. Esta abordagem e fundamentada em Arranjos de Interacao, os quais representam fluxos recorrentes de interacao entre elementos abstratos do dominio IoT. Estes arranjos puderam ser desenhados aplicando-se uma abordagem baseada em evidencia, ou seja, considerando os resultados obtidos por meio de uma revisao estruturada da literatura conduzida com o objetivo de identificar, analisar e interpretar os conceitos e propriedades do dominio IoT. A abordagem ScenarIoT foi aplicada em dois projetos de turmas de graduacao com o objetivo de observar a sua utilidade. Os resultados dos estudos mostraram que a abordagem e util considerando o contexto onde foi aplicada.

Profiling molecular regulators of recurrence in chemorefractory triple-negative breast cancers

Abstract: Approximately two thirds of patients with localized triple-negative breast cancer (TNBC) harbor residual disease (RD) after neoadjuvant chemotherapy (NAC) and have a high risk-of-recurrence. Targeted therapeutic development for TNBC is of primary significance as no targeted therapies are clinically indicated for this aggressive subset. In view of this, we conducted a comprehensive molecular analysis and correlated molecular features of chemorefractory RD tumors with recurrence for the purpose of guiding downstream therapeutic development. We assembled DNA and RNA sequencing data from RD tumors as well as pre-operative biopsies, lymphocytic infiltrate, and survival data as part of a molecular correlative to a phase II post-neoadjuvant clinical trial. Matched somatic mutation, gene expression, and lymphocytic infiltrate were assessed before and after chemotherapy to understand how tumors evolve during chemotherapy. Kaplan-Meier survival analyses were conducted categorizing cancers with TP53 mutations by the degree of loss as well as by the copy number of a locus of 18q corresponding to the SMAD2, SMAD4, and SMAD7 genes. Analysis of matched somatic genomes pre-/post-NAC revealed chaotic acquisition of copy gains and losses including amplification of prominent oncogenes. In contrast, significant gains in deleterious point mutations and insertion/deletions were not observed. No trends between clonal evolution and recurrence were identified. Gene expression data from paired biopsies revealed enrichment of actionable regulators of stem cell-like behavior and depletion of immune signaling, which was corroborated by total lymphocytic infiltrate, but was not associated with recurrence. Novel characterization of TP53 mutation revealed prognostically relevant subgroups, which were linked to MYC-driven transcriptional amplification. Finally, somatic gains in 18q were associated with poor prognosis, likely driven by putative upregulation of TGFs signaling through the signal transducer SMAD2. We conclude TNBCs are dynamic during chemotherapy, demonstrating complex plasticity in subclonal diversity, stem-like qualities, and immune depletion, but somatic alterations of TP53/MYC and TGFs signaling in RD samples are prominent drivers of recurrence, representing high-yield targets for additional interrogation.

Design and development of multifunctional patient bed with integrated toilet

Abstract: This paper presents a new bed for bedridden patients. It has provision for using a commode by pulling it up to the bed height by a specially designed mechanism. For commode use, it has an opening in the bed. A mattress on the platform covers the commode opening. After use, the commode is pushed back to its position below the bed. Then, the commode opening gets covered. This bed also has provision for side turning of the patient. The left and right-side turning mechanisms can operate independently to allow the patient to sleep on the left or right side. It is possible to turn both sides together to avoid touching the middle part of the back to the bed surface to avoid pressure ulcers. The side turning may be simultaneously operated with the backrest. A separate mechanism is there for this purpose. In addition, the bed can be converted into a chair position and has other utilities like a washbasin, folding table, and cistern attached to it. The bed design and development are in two stages. First, a bed with a commode is designed. Later, this design is improved to add a side turning mechanism. Computer modeling, simulation, fabrication, and testing are employed to plan and check bed operations and positions. The mechanical performance of the bed is compared with the simulation results, and the errors are negligible. The bed is compared with the reported designs in the literature. It is a novel product. It will be excellent equipment for bedridden patients and caregivers.