Author
Prem Raj
Bio: Prem Raj is an academic researcher from University of Lucknow. The author has contributed to research in topics: Trigonal bipyramidal molecular geometry & Antimony. The author has an hindex of 13, co-authored 48 publications receiving 368 citations.
Papers
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TL;DR: In an effort to identify new candidates that may be of value in designing new, potent, selective, and less toxic anticancer, antiviral, and/or antimicrobial agents, 3-substituted benzoxazole derivatives are synthesized.
Abstract: Benzoxazole derivatives show various types of biological properties such as antiviral, antineoplastic, anti-HIV-1, antitubercular, anthelmintic, antimicrobial, and antifungal activities. In the last few years 2-substituted benzoxazole derivatives have been studied extensively for their antitumor, antiviral, and antimicrobial activities. In an effort to identify new candidates that may be of value in designing new, potent, selective, and less toxic anticancer, antiviral, and/or antimicrobial agents, we synthesized 2-[(arylhydrazono) cyanomethyl]-5-chloro benzoxazoles (II), 2-[(arylidene)cyanomethyl]-5-halo benzoxazoles (III), and 2-[(cycloalkylidine)cyanomethyl]-5-chlorobenzoxazoles (IV), and tested them for anticancer, antifungal, and antibacterial activities. Some of these (compounds 11, 14) were found to possess anticancer activity and remarkable antifungal as well as antibacterial activities.
39 citations
TL;DR: In this paper, it was shown that (C6F5)3SbCl2 with appropriate metallic salts yield covalent pentacoordinate disubstituted products (V, VII-XII) of the general formula, (C 6F5, 3SbY2 (Y = NCS, NCO, −ONCMe2, −onCMePh −NCO(CH 2 ) 2 C O and p-NO2C6H4OCO), which are also accessible by displacement reaction of (I or (II
35 citations
TL;DR: In this article, penta-coordinated triaryl-arsenic(V) complexes of Schiff bases of the general formula Ar3AsL (Ar = C6H5, p-CH3C6H4, pclC 6H4 and p-FC6H 4) have been synthesized along with some triarylantimony complexes with similar tridentate ligands.
Abstract: Hitherto unreported penta-coordinated triaryl-arsenic(V) complexes of Schiff bases of the general formula Ar3AsL (Ar = C6H5, p-CH3C6H4, p-ClC6H4, p-FC6H4 and C6F5; L = dibasic tri-and tetradentate ligands with ONO and ONNO systems) have been synthesised along with some triarylantimony complexes with similar tridentate ligands. The complexes, which are yellow crystalline solids, have been characterised by elemental analyses, IR, 1H and 19F NMR spectral data sp3d and sp3d2 hybridisation has been suggested for the arsenic and antimony derivatives, respectively, on the basis of spectral data.
24 citations
TL;DR: In this paper, the redistribution reactions with SbCl3 in 2 1 and 1 2 molar ratios were found to give quantitative yields of (C6F5)2SbCl (II) (c6F 5)SbCL2 (III), respectively.
21 citations
TL;DR: In this article, the authors show that the absence of coordination of ClO 4 group to Sb atom in cationic complexes conform to the requirement of octahedral configuration for neural complexes (I ) and a trigonal bipyramidal structure for complex cations ( II ) and ( III ).
21 citations
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TL;DR: This review addresses the areas such as the underlying mechanisms, eight different targets such as ergosterol synthesis, chitin synthesis, ergosterols disruptors, glucan synthesis, squalene epoxidase, nucleic acid synthesis, protein synthesis, microtubules synthesis, and the current research work going on worldwide on different heterocycles.
522 citations
TL;DR: Several of the synthesized products were subjected to in vitro anticancer screening that revealed that all the tested compounds exhibited antitumor activity against human hepatocellular carcinoma, human breast adenocarcinoma and human colon carcinoma cell lines, with IC50's<10 microg/ml.
217 citations
TL;DR: New divalent osmium complexes that feature strong red metal-to-ligand-charge-transfer (MLCT) phosphorescence and electrophosphorescence and 2-tert-butylphenyl-5-biphenyl-1,3,4-oxadiazole (PBD) are reported.
Abstract: We report new divalent osmium complexes that feature strong red metal-to-ligand-charge-transfer (MLCT) phosphorescence and electrophosphorescence. The general formula of the complexes is Os(II)(N−N)2L−L, where N−N is either a bipyridine or a phenanthroline and L−L is either a phosphine or an arsine. New polypyridyl ligands synthesized are 4,4‘-di(biphenyl)-2,2‘-bipyridine (15) and 4,4‘-di(diphenyl ether)-2,2‘-bipyridine (16), and the 1,10-phenanthroline derivatives synthesized are 4,7-bis(p-methoxyphenyl)-1,10-phenanthroline (17), 4,7-bis(p-bromophenyl)-1,10-phenanthroline (18), 4,7-bis(4‘-phenoxybiphen-4-yl)-1,10-phenanthroline (19), and 4,7-bis(4-naphth-2-ylphenyl)-1,10-phenanthroline (20). 4,4‘-Diphenyl-2,2‘-bipyridine (21) and 4,7-diphenyl-1,10-phenanthroline (22) were also used in these studies. Strong π-acid ligands used were 1,2-bis(diphenylarseno)ethane (23), cis-1,2-bis(diphenylphosphino)ethylene (24), and cis-1,2-vinylenebis(diphenylarsine) (25). Ligand 25 is used for the first time in these typ...
209 citations
Patent•
22 Dec 2005
TL;DR: In this article, the present invention relates to a doped organic semiconductor material comprising an organic matrix material which is doped with at least one heteromonocyclic and/or heteropolycyclic compound.
Abstract: The present invention relates to a doped organic semiconductor material comprising an organic matrix material which is doped with at least one heteromonocyclic and/or heteropolycyclic compound, the compound having at least one nitrogen atom with a free electron pair.
128 citations