P
Premkumar Jayaraj
Researcher at VIT University
Publications - 6
Citations - 70
Premkumar Jayaraj is an academic researcher from VIT University. The author has contributed to research in topics: Crystal structure & Targeted drug delivery. The author has an hindex of 3, co-authored 6 publications receiving 30 citations.
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Journal ArticleDOI
Sesamol: a powerful functional food ingredient from sesame oil for cardioprotection.
Premkumar Jayaraj,Chandrakala Aluganti Narasimhulu,Sanjay Rajagopalan,Sampath Parthasarathy,Rajagopal Desikan,Rajagopal Desikan +5 more
TL;DR: This review offers a perspective on the existing literature on functional ingredients in sesame oil with particular focus on sesamol and its derivatives having nutritional and cardioprotective properties, and demonstrates a specifically modulating oxidative enzyme myeloperoxidase (MPO) and other proteins which are detrimental to human well-being.
Journal ArticleDOI
Methoxyphenol derivatives as reversible inhibitors of myeloperoxidase as potential antiatherosclerotic agents.
Premkumar Jayaraj,Chandrakala Aluganti Narasimhulu,Andrei Maiseyeu,Rekha Durairaj,Shashidhar N. Rao,Sanjay Rajagopalan,Sampath Parthasarathy,Rajagopal Desikan,Rajagopal Desikan +8 more
TL;DR: Lead analogs are potent MPOIs that exert specific effects on MPO-mediated oxidation as well as inflammatory pathways that sheds light on pharmacological approach in atherosclerosis treatment.
Journal ArticleDOI
A pre-formulation strategy for the liposome encapsulation of new thioctic acid conjugates for enhanced chemical stability and use as an efficient drug carrier for MPO-mediated atherosclerotic CVD treatment
Premkumar Jayaraj,Gopal Venkatesh Shavi,Ananda Kumar Srinivasan,Ramesh Raghavendra,Akella Sivaramakrishna,Rajagopal Desikan,Rajagopal Desikan +6 more
TL;DR: This is the first report of a highly efficient and sustainable chemical method for the liposomal encapsulation of thioctic acid conjugates of apocynin and sesamol that has been substantiated using relevant in vitro assays, and it could be useful for MPO-mediated atherosclerotic CVD treatment.
Book ChapterDOI
Hydrogel Formulation as Efficient Drug Carrier and Delivery for Selected Skin Diseases
Ramakrishnan Kumar,Sujitha Ayyanar,Premkumar Jayaraj,Akella Sivaramakrishna,Sanjay Rajagopalan,Sampath Parthasarathy,Rajagopal Desikan,Rajagopal Desikan +7 more
TL;DR: In this paper, the current trends in hydrogel-based drug carrier cum delivery systems for skin diseases like skin cancer, psoriasis and wound healing are highlighted and future forecasts and prospects are also discussed.
Journal ArticleDOI
In Silico Analysis to Link Insulin Resistance, Obesity and Ageing with Alzheimer’s Disease
Priyanka Sarkar,Premkumar Jayaraj,Ketaki Patwardhan,Samiksha Yeole,Sourajit Das,Yash Rupeshkumar Somaiya,Rajagopal Desikan,Kavitha Thirumurugan +7 more
TL;DR: This study performed an in silico analysis to relate the process of ageing and insulin resistance, and analyzed the common genes in Alzheimer's disease and fly data with human data to identify the diseases related to these common genes.