P
Priscilla E. M. Purnick
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 5
Citations - 1475
Priscilla E. M. Purnick is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Synthetic biology & Modular design. The author has an hindex of 4, co-authored 5 publications receiving 1389 citations. Previous affiliations of Priscilla E. M. Purnick include Princeton University.
Papers
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Journal ArticleDOI
The second wave of synthetic biology: from modules to systems
TL;DR: To view cells as true 'programmable' entities, it is now essential to develop effective strategies for assembling devices and modules into intricate, customizable larger scale systems.
Journal ArticleDOI
Thick film laser induced forward transfer for deposition of thermally and mechanically sensitive materials
TL;DR: In this paper, a thin polymer absorbing layer was used to dissipate shock energy through mechanical deformation, and multiple mechanisms for transfer as a function of incident laser energy were observed and viable and contamination-free deposition of living mammalian embryonic stem cells.
Modular Design of Artificial Tissue Homeostasis: Robust Control through Synthetic Cellular Heterogeneity
Miles A. Miller,Marc Hafner,Eduardo D. Sontag,Noah Davidsohn,Sairam Subramanian,Priscilla E. M. Purnick,Douglas A. Lauffenburger,Ron Weiss +7 more
TL;DR: In this article, the authors present the design, system integration, and analysis of several large scale synthetic gene circuits for artificial tissue homeostasis, where genetically programmed stem cells maintain a steady population of β-cells despite continuous turnover.
Journal ArticleDOI
Modular Design of Artificial Tissue Homeostasis: Robust Control through Synthetic Cellular Heterogeneity
Miles A. Miller,Marc Hafner,Eduardo D. Sontag,Noah Davidsohn,Sairam Subramanian,Priscilla E. M. Purnick,Douglas A. Lauffenburger,Ron Weiss +7 more
TL;DR: It is found that designing modules for synthetic heterogeneity can be complex, and in general requires a framework for non-linear and multifactorial analysis, so a ‘phenotypic sensitivity analysis’ method is adapted to determine how functional module behaviors combine to achieve optimal system performance.
Patent
Engineered cellular pathways for programmed autoregulation of differentiation
Ron Weiss,Ihor R. Lemischka,Priscilla E. M. Purnick,Christoph Schaniel,Miles A. Miller,Patrick Guye +5 more
TL;DR: A quorum sensing system that regulates the expression of cell fate regulators is introduced into mammalian host cells, such as stem cells as mentioned in this paper, which can be used to program mammalian cells to perform desired functions.