P
Priya Dayananth
Researcher at Myriad Genetics
Publications - 10
Citations - 7464
Priya Dayananth is an academic researcher from Myriad Genetics. The author has contributed to research in topics: Gene & Positional cloning. The author has an hindex of 8, co-authored 9 publications receiving 7214 citations.
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Journal ArticleDOI
A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1
Yoshio Miki,Jeff Swensen,Donna M Shattuck-Eidens,P. Andrew Futreal,Keith D Harshman,Sean V. Tavtigian,Qingyun Liu,Charles Cochran,L. Michelle Bennett,Wei Ding,Russell Bell,Judith Rosenthal,Charles E. Hussey,Thanh Tran,Melody McClure,Cheryl Frye,Tom Hattier,Robert Phelps,Astrid Haugen-Strano,Harold Katcher,Kazuko Yakumo,Zahra Gholami,Daniel Shaffer,Steven Stone,Steven Bayer,Christian Wray,Robert Bogden,Priya Dayananth,John R. Ward,Patricia N. Tonin,Steven A. Narod,Pam K. Bristow,Frank H. Norris,Leah M. Helvering,Paul Morrison,Paul Robert Rosteck,Mei Lai,J. Carl Barrett,Cathryn M. Lewis,Susan L. Neuhausen,Lisa A. Cannon-Albright,David E. Goldgar,Roger W. Wiseman,Alexander Kamb,Mark H. Skolnick +44 more
TL;DR: A strong candidate for the 17q-linked BRCA1 gene, which influences susceptibility to breast and ovarian cancer, has been identified by positional cloning methods.
Journal ArticleDOI
A candidate prostate cancer susceptibility gene at chromosome 17p.
Sean V. Tavtigian,Jacques Simard,David H. F. Teng,Vicki Abtin,Michelle Baumgard,Audrey Beck,Nicola J. Camp,Nicola J. Camp,Arlene Carillo,Yang Chen,Priya Dayananth,Marc Desrochers,Martine Dumont,James M. Farnham,David A. Frank,Cheryl Frye,Siavash Ghaffari,Jamila Gupte,Rong Hu,Diana Iliev,Teresa Janecki,Edward N. Kort,Kirsten Laity,Amber Leavitt,Gilles Leblanc,Jodi Mcarthur-Morrison,Amy Pederson,Brandon Penn,Kelly T. Peterson,Julia Reid,Sam Richards,Marianne Schroeder,Richard D. Smith,Sarah C. Snyder,Brad Swedlund,Jeff Swensen,Alun Thomas,Martine Tranchant,Ann Marie Woodland,Fernand Labrie,Mark H. Skolnick,Susan L. Neuhausen,Johanna M. Rommens,Lisa A. Cannon-Albright,Lisa A. Cannon-Albright +44 more
TL;DR: A genome-wide scan of large, high-risk pedigrees from Utah has provided evidence for linkage to a locus on chromosome 17p, identifying a gene, ELAC2, harboring mutations (including a frameshift and a nonconservative missense change) that segregate with prostate cancer in two pedigree.
Journal Article
Complex Structure and Regulation of the P16 (MTS1) Locus
Steven Stone,Ping Jiang,Priya Dayananth,Sean V. Tavtigian,Harold Katcher,David Parry,Gordon Peters,Alexander Kamb +7 more
TL;DR: Two transcripts derived from the p16 gene with distinct protein coding potentials are described, and transcription from one of the promoters appears to be regulated, at least in part, by the retinoblastoma gene product.
Journal ArticleDOI
Characterization of a Carboxy-Terminal BRCA1 Interacting Protein
Alexander K. C. Wong,Patricia A. Ormonde,Ralph Pero,Yuan Chen,Lubing Lian,Grant Salada,Simin Berry,Quentin Lawrence,Priya Dayananth,Phuong C. Ha,Sean V. Tavtigian,David H. F. Teng,Paul L. Bartel +12 more
TL;DR: Using the yeast two-hybrid and in vitro biochemical assays, it is shown that a protein, CtIP, interacts specifically with the carboxy-terminal segment of human BRCA1 from residues 1602–1863.
Journal Article
Genomic structure, expression and mutational analysis of the P15 (MTS2) gene.
Steven Stone,Priya Dayananth,Ping Jiang,Jane Weaver-Feldhaus,Sean V. Tavtigian,Lisa A. Cannon-Albright,Alexander Kamb +6 more
TL;DR: It is shown that ectopic expression of p15 inhibits growth of tumor-derived cell lines and a role for p15 in growth regulation, but a limited role in tumor progression is suggested.