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Purnendu K. Dasgupta

Bio: Purnendu K. Dasgupta is an academic researcher from University of Texas at Arlington. The author has contributed to research in topics: Ion chromatography & Detection limit. The author has an hindex of 62, co-authored 506 publications receiving 16779 citations. Previous affiliations of Purnendu K. Dasgupta include Dow Chemical Company & Texas Tech University.


Papers
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Journal ArticleDOI
TL;DR: In this article, a light emitting diode (LED) based dual-wavelength photometric system utilizing personal computer (PC) based data acquisition and processing was introduced for flow-injection extraction, where absorbance is read radially, on the same PTFE tube that constitutes the reaction coil, near its distal terminus.

44 citations

Journal ArticleDOI
15 Mar 2009-Talanta
TL;DR: While it is found that the removal of the developed color can be accelerated by simultaneous heating and suction, permitting the reuse of the same sensing area multiple times, it is also observed that the sensitivity gradually decreased.

44 citations

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TL;DR: In this paper, a mechanism for the photomediated reaction involving an aryloxy radical derived from the substrate is suggested, which is the same as that formed in the peroxidase enzyme-mediated H2O2 oxidation of HPA.

44 citations

Journal ArticleDOI
TL;DR: In this paper, a fluorimetric flow-injection procedure with a single reagent solution containing p-hydroxyphenylacetic acid, peroxidase and ammonia was proposed.

43 citations

Journal ArticleDOI
TL;DR: The method was validated against a microdiffusion approach and applied to the measurement of cyanide in rabbit and human blood, and permits field measurement of blood cyanides in <4 min.

43 citations


Cited by
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Journal ArticleDOI
27 Jul 2006-Nature
TL;DR: The manipulation of fluids in channels with dimensions of tens of micrometres — microfluidics — has emerged as a distinct new field that has the potential to influence subject areas from chemical synthesis and biological analysis to optics and information technology.
Abstract: The manipulation of fluids in channels with dimensions of tens of micrometres--microfluidics--has emerged as a distinct new field. Microfluidics has the potential to influence subject areas from chemical synthesis and biological analysis to optics and information technology. But the field is still at an early stage of development. Even as the basic science and technological demonstrations develop, other problems must be addressed: choosing and focusing on initial applications, and developing strategies to complete the cycle of development, including commercialization. The solutions to these problems will require imagination and ingenuity.

8,260 citations

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TL;DR: It is reported that magnetite nanoparticles in fact possess an intrinsic enzyme mimetic activity similar to that found in natural peroxidases, which are widely used to oxidize organic substrates in the treatment of wastewater or as detection tools.
Abstract: Nanoparticles containing magnetic materials, such as magnetite (Fe3O4), are particularly useful for imaging and separation techniques. As these nanoparticles are generally considered to be biologically and chemically inert, they are typically coated with metal catalysts, antibodies or enzymes to increase their functionality as separation agents. Here, we report that magnetite nanoparticles in fact possess an intrinsic enzyme mimetic activity similar to that found in natural peroxidases, which are widely used to oxidize organic substrates in the treatment of wastewater or as detection tools. Based on this finding, we have developed a novel immunoassay in which antibody-modified magnetite nanoparticles provide three functions: capture, separation and detection. The stability, ease of production and versatility of these nanoparticles makes them a powerful tool for a wide range of potential applications in medicine, biotechnology and environmental chemistry.

4,500 citations

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TL;DR: The ability of DLLME technique in the extraction of other organic compounds such as organochlorine pesticides, organophosphorus pesticides and substituted benzene compounds were studied.

2,959 citations

Journal ArticleDOI
TL;DR: It is concluded that when nonmonotonic dose-response curves occur, the effects of low doses cannot be predicted by the effects observed at high doses, and fundamental changes in chemical testing and safety determination are needed to protect human health.
Abstract: For decades, studies of endocrine-disrupting chemicals (EDCs) have challenged traditional concepts in toxicology, in particular the dogma of “the dose makes the poison,” because EDCs can have effects at low doses that are not predicted by effects at higher doses. Here, we review two major concepts in EDC studies: low dose and nonmonotonicity. Low-dose effects were defined by the National Toxicology Program as those that occur in the range of human exposures or effects observed at doses below those used for traditional toxicological studies. We review the mechanistic data for low-dose effects and use a weight-of-evidence approach to analyze five examples from the EDC literature. Additionally, we explore nonmonotonic dose-response curves, defined as a nonlinear relationship between dose and effect where the slope of the curve changes sign somewhere within the range of doses examined. We provide a detailed discussion of the mechanisms responsible for generating these phenomena, plus hundreds of examples from...

2,475 citations

Journal ArticleDOI
23 Sep 2011-Thyroid
TL;DR: The revised guidelines for the management of thyroid disease in pregnancy include recommendations regarding the interpretation of thyroid function tests in pregnancy, iodine nutrition, thyroid autoantibodies and pregnancy complications, thyroid considerations in infertile women, hypothyroidism in pregnancy and thyrotoxicosis in pregnancy.
Abstract: Background: Thyroid disease in pregnancy is a common clinical problem. Since the guidelines for the management of these disorders by the American Thyroid Association (ATA) were first published in 2...

2,409 citations