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Purnendu K. Dasgupta

Bio: Purnendu K. Dasgupta is an academic researcher from University of Texas at Arlington. The author has contributed to research in topics: Ion chromatography & Detection limit. The author has an hindex of 62, co-authored 506 publications receiving 16779 citations. Previous affiliations of Purnendu K. Dasgupta include Dow Chemical Company & Texas Tech University.


Papers
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Journal ArticleDOI
TL;DR: A S(IV)-containing preservative has been formulated for the stabilization of low concentrations of HCHO and is very selective to formaldehyde compared to other carbonyl compounds.
Abstract: Formaldehyde can be determined in aqueous solution at a rate of 45 samples/h with a small sample requirement (100 ..mu..L). The fluorescence of 3,5-diacetyl-1,4-dihydrolutidine formed upon reaction of formaldehyde with ammonium acetate and 2,4-pentanedione (25 s, 95 /sup 0/C) is monitored with a filter fluorometer. The detection limit is 0.1 ..mu..M (3 ..mu..g/L) or 10 pmol of HCHO. The response is linear up to 3.3 ..mu..M (100 ..mu..g/L), the departure from linearity at 0.33 mM is 21%, but high levels are satisfactorily determined with a second-order calibration equation. Interference from S(IV) has been investigated in detail and completely eliminated by addition of H/sub 2/O/sub 2/ before rendering the sample alkaline. There are no effects from commonly occurring metal ions and anions; the method is very selective to formaldehyde compared to other carbonyl compounds. A S(IV)-containing preservative has been formulated for the stabilization of low concentrations of HCHO. Results are presented for fogwater samples. 8 figures, 41 references.

114 citations

Journal ArticleDOI
TL;DR: A general review of iodine determination on a wide-ranging set of complex matrices is not available and no available technique fully fits the needs of developing countries; research into inexpensive reliable methods and instrumentation are needed.

114 citations

Journal ArticleDOI
TL;DR: An automated measurement system for HONO(g) and HNO 3 (g) along with particulate nitrite and nitrate is described and displays very low interference from NO and NO 2.
Abstract: An automated measurement system for HONO(g) and HNO 3 (g) along with particulate nitrite and nitrate is described. The system alternately measures the gas phase and aerosol phase constituents. The gases are collected by a parallel plate wet denuder, and the effluent aerosol is collected by steam condensation, followed by impaction/thermophoresis. The fully automated instrument provides separate but quantitative collection of gases and particles at relatively high flow rates and displays very low interference from NO and NO 2 . Coupled to an anion chromatograph, the detection limit estimated for a signal equivalent to that of three times the noise level of the blank is 110 parts per quadrillion (ppq, 10 -15 atm) and 230 ppq of gaseous HONO and HNO 3 , respectively, and 230 and 650 pg/m 3 aerosol nitrite and nitrate, respectively, for a 8-min integrated sample. The instrument operates over prolonged periods with minimal attention. Data are reported for outdoor ambient air measurements and for indoor air with kerosene-fueled space heaters in operation.

112 citations

Journal ArticleDOI
TL;DR: Iodine is significantly lost upon high humidity storage but light or dry heat has little effect%; there is much recent literature on iodine sufficiency and uptake inhibitors; there is also much misinformation and disinformation.
Abstract: Adequacy of iodine nutrition in the United States has lately been of concern. A major source of dietary iodine for the U.S. population is iodized salt. The U.S. Food and Drug Administration (USFDA) recommends 60–100 mg KI/kg salt, equivalent to 46–76 mg I/kg salt. All U.S. iodized salt contains 45 mg I/kg according to labels. We collected samples of table salt from freshly opened containers from U.S. volunteers. A sample was sent to us when the can was first purchased. Subsets of volunteers sent further samples when the salt container became half-empty through normal use and a further final sample when the container was nearly finished. We also looked at iodine distribution homogeneity within individual containers, loss of iodine from salt upon exposure to humidity and sunlight, and upon short-term heating (dry and in solution) as may be encountered in cooking. Measurements were made in 0.01% w/v salt solutions by induction coupled plasma−mass spectrometry with 72Ge as an internal standard. The median and...

110 citations

Journal ArticleDOI
TL;DR: Cow's milk samples from Japan show high levels of perchlorate, which are higher on average than those found in U.S. dairy milk samples reported by a 2004 Food and Drug Administration study.
Abstract: Perchlorate has been considered a potential threat to human health, especially to developing infants and children due to its ability to inhibit iodide uptake by the sodium iodide symporter (NIS) of the thyroid. Although the U.S. has been the prime focus of perchlorate contamination, at least some of the similar sources of perchlorate exist across the world, and it has been detected in many types of foods and beverages worldwide. We present here perchlorate data from cow's milk samples from Japan (mean 9.4 ± 2.7 μg/L, n = 54), which are higher on average than those found in U.S. dairy milk samples reported by a 2004 Food and Drug Administration (FDA) study (5.9 ± 1.8 μg/L, n = 104).

108 citations


Cited by
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Journal ArticleDOI
27 Jul 2006-Nature
TL;DR: The manipulation of fluids in channels with dimensions of tens of micrometres — microfluidics — has emerged as a distinct new field that has the potential to influence subject areas from chemical synthesis and biological analysis to optics and information technology.
Abstract: The manipulation of fluids in channels with dimensions of tens of micrometres--microfluidics--has emerged as a distinct new field. Microfluidics has the potential to influence subject areas from chemical synthesis and biological analysis to optics and information technology. But the field is still at an early stage of development. Even as the basic science and technological demonstrations develop, other problems must be addressed: choosing and focusing on initial applications, and developing strategies to complete the cycle of development, including commercialization. The solutions to these problems will require imagination and ingenuity.

8,260 citations

Journal ArticleDOI
TL;DR: It is reported that magnetite nanoparticles in fact possess an intrinsic enzyme mimetic activity similar to that found in natural peroxidases, which are widely used to oxidize organic substrates in the treatment of wastewater or as detection tools.
Abstract: Nanoparticles containing magnetic materials, such as magnetite (Fe3O4), are particularly useful for imaging and separation techniques. As these nanoparticles are generally considered to be biologically and chemically inert, they are typically coated with metal catalysts, antibodies or enzymes to increase their functionality as separation agents. Here, we report that magnetite nanoparticles in fact possess an intrinsic enzyme mimetic activity similar to that found in natural peroxidases, which are widely used to oxidize organic substrates in the treatment of wastewater or as detection tools. Based on this finding, we have developed a novel immunoassay in which antibody-modified magnetite nanoparticles provide three functions: capture, separation and detection. The stability, ease of production and versatility of these nanoparticles makes them a powerful tool for a wide range of potential applications in medicine, biotechnology and environmental chemistry.

4,500 citations

Journal ArticleDOI
TL;DR: The ability of DLLME technique in the extraction of other organic compounds such as organochlorine pesticides, organophosphorus pesticides and substituted benzene compounds were studied.

2,959 citations

Journal ArticleDOI
TL;DR: It is concluded that when nonmonotonic dose-response curves occur, the effects of low doses cannot be predicted by the effects observed at high doses, and fundamental changes in chemical testing and safety determination are needed to protect human health.
Abstract: For decades, studies of endocrine-disrupting chemicals (EDCs) have challenged traditional concepts in toxicology, in particular the dogma of “the dose makes the poison,” because EDCs can have effects at low doses that are not predicted by effects at higher doses. Here, we review two major concepts in EDC studies: low dose and nonmonotonicity. Low-dose effects were defined by the National Toxicology Program as those that occur in the range of human exposures or effects observed at doses below those used for traditional toxicological studies. We review the mechanistic data for low-dose effects and use a weight-of-evidence approach to analyze five examples from the EDC literature. Additionally, we explore nonmonotonic dose-response curves, defined as a nonlinear relationship between dose and effect where the slope of the curve changes sign somewhere within the range of doses examined. We provide a detailed discussion of the mechanisms responsible for generating these phenomena, plus hundreds of examples from...

2,475 citations

Journal ArticleDOI
23 Sep 2011-Thyroid
TL;DR: The revised guidelines for the management of thyroid disease in pregnancy include recommendations regarding the interpretation of thyroid function tests in pregnancy, iodine nutrition, thyroid autoantibodies and pregnancy complications, thyroid considerations in infertile women, hypothyroidism in pregnancy and thyrotoxicosis in pregnancy.
Abstract: Background: Thyroid disease in pregnancy is a common clinical problem. Since the guidelines for the management of these disorders by the American Thyroid Association (ATA) were first published in 2...

2,409 citations