Author
Purnima D. Amin
Other affiliations: Government of India, University of Mumbai, Government of Maharashtra
Bio: Purnima D. Amin is an academic researcher from Institute of Chemical Technology. The author has contributed to research in topics: Solubility & Dissolution. The author has an hindex of 19, co-authored 89 publications receiving 922 citations. Previous affiliations of Purnima D. Amin include Government of India & University of Mumbai.
Topics: Solubility, Dissolution, Extrusion, Medicine, Granulation
Papers published on a yearly basis
Papers
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TL;DR: In this article, an immediate release solid dispersion (SD) formulation of antiulcer drug lafutidine (LAFT) was developed using hot melt extrusion (HME) technique.
65 citations
TL;DR: The optimized ASDs batch were stable at 40°C, 75% RH for a period of 6months without any dissolution rate changes, and remained into amorphous state, according to observations inferred from DSC, XRD and in vitro dissolution studies.
59 citations
TL;DR: In this article, the authors used molecular dynamic simulation approach to investigate drug-polymer molecular interaction using computational modelling Schrodinger® software and found that amorphosization of LUMF powder makes the Coartem® therapy more operative with value-added beneficial comeback.
Abstract: The interest in hot-melt extrusion as a drug delivery technology for the production of solid dispersion is growing rapidly. Lumefantrine (LUMF) is an antimalarial drug that exhibits poor oral bioavailability, in consequence of its poor aqueous solubility. To improve its antimalarial activity, solid dispersion formulation using hot melt extrusion technology was prepared. Appropriate selection of polymers, favoured the production of amorphous LUMF-polymer solid dispersions. The physicochemical properties of solid dispersions were characterized using scanning electron microscope, Infrared spectroscopy, differential scanning calorimetry and X-ray diffraction. LUMF SD showed enhanced dissolution rate attributed to amorphosization of LUMF. The IC50 value of LUMF SD formulations was found to be (0.084–0.213 ng/mL) i.e. 220–101 times lower than the IC50 value of pure LUMF (18.2 ng/mL) and 45–18 times lower than the IC50 value of standard antimalarial drug, chloroquine (3.8 ng/mL). Molecular dynamic simulation approach was used to investigate drug-polymer molecular interaction using computational modelling Schrodinger® software. LUMF SD powder makes the Coartem® therapy more operative with value-added beneficial comeback.
44 citations
TL;DR: In this article, solid dispersions of ARM with polymers were prepared with Soluplus, Kollidon VA 64, HPMC and Eudragit EPO at weight ratios of 1:1, 1:2, and 1:3 using spray drying technology, and characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry (DSC), and X-ray powder diffraction (XRD) to identify the physicochemical interaction between drug and carrier, as well as effect on dissolution.
42 citations
TL;DR: In this article, a solid dispersions (SDs) of CUR in aqueous and organic solvent using Eudragit EPO (EuD) were prepared by spray drying and rota evaporation technique.
40 citations
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2,177 citations
TL;DR: This review attempts to address the critical molecular and thermodynamic aspects governing the physicochemical properties of amorphous solid dispersion systems and potential advantage of polymers as inert, hydrophilic, pharmaceutical carrier matrices.
680 citations
TL;DR: Based on the special characteristics of carrageenan, it has been used as a gelling agent/viscosity enhancing agent for controlled drug release and prolonged retention and for tissue regeneration with therapeutic biomacromolecules and for cell delivery.
413 citations
TL;DR: In this paper, the authors focus on the utilization of liquid anti-solvent precipitation as a means of producing food-grade nanoparticles, which vary in their ease of use, cost, and robustness.
Abstract: An increasing number of different types of nanoparticles are being developed for utilization within the food industry in which these are used to encapsulate, protect, and release active food ingredients. They can also be used to overcome undesirable effects on food quality due to fat, sugar, or salt reduction, or to act as sensors to detect contaminants or microbial spoilage in food products. Several techniques have been developed to fabricate food-grade nanoparticles, which vary in their ease of use, cost, and robustness. In this review, we focus on the utilization of liquid anti-solvent precipitation as a means of producing food-grade nanoparticles.
275 citations