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Pushkar P. Matkari

Bio: Pushkar P. Matkari is an academic researcher from Government Medical College, Thiruvananthapuram. The author has contributed to research in topics: Syphilitic aortitis & Sudden cardiac death. The author has an hindex of 2, co-authored 3 publications receiving 23 citations.

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Journal ArticleDOI
TL;DR: It is important to know the histological pattern of the endometrium like proliferative endometum, endometrial hyperplasia, atrophic endometium, secretory endometarium, irregular ripening and shredding and organic lesions in patients diagnosed as AUB in different age groups since recognition of these conditions will help and will avoid further complications.
Abstract: Background: Abnormal uterine bleeding is one of the commonest complaints in women and when it occurs without organic lesions like tumor, inflammation, it is called as dysfunctional uterine bleeding. Aim of current study was to find out the histopathological pattern of endometrium in Abnormal Uterine Bleeding (AUB) also to study organic causes of AUB. Methods: Specimens received as endometrial curettage and hysterectomy specimens were studied followed by correlation of histopathology with age and clinical presentation. Results: The patients were mainly from the age group of 30-49 years (74.24%). The most common menstrual disorder was menorrhagia (46.86%). In dysfunctional uterine bleeding the most common histological pattern of endometrium includes proliferative endometrium (22.8%) followed by endometrial hyperplasia (19.40%), atrophic endometrium (7.16%), secretory endometrium (5.97%), irregular shedding [1.80%], irregular ripening (1.20%) and anovulatory endometrium (0.59%). Organic lesions encountered in AUB cases were leiomyoma (17.92%), endometrial polyp (1.79%), endometrial carcinoma (1.50%), endometriosis (0.59%) and choriocarcinoma (0.29%). Conclusion: It is important to know the histological pattern of the endometrium like proliferative endometrium, endometrial hyperplasia, atrophic endometrium, secretory endometrium, irregular ripening and shredding and organic lesions in patients diagnosed as AUB in different age groups since recognition of these conditions will help and will avoid further complications.

20 citations

Journal ArticleDOI
TL;DR: An interesting case of 55 years male with multiple neurofibromas all over the body since 30 years and multiple café-au-lait spots, diagnosed as NF-1, and the diagnosis of MTT, which was confirmed on immunohistochemistry.
Abstract: Malignant peripheral nerve sheath tumor (MPNST) with rhabdomyoblastic differentiation is called as malignant triton tumor (MTT). It is highly aggressive soft tissue tumor with higher local recurrence rate. MTT has poor prognosis than MPNST. MTT seems to be more aggressive in patients with neurofibromatosis (NF-1). We herein, reporting an interesting case of 55 years male with multiple neurofibromas all over the body since 30 years and multiple cafe-au-lait spots, diagnosed as NF-1. Since 6 years, he had an enlarged mass in left thigh. Wide excision of mass was done. On histopathological examination revealed the diagnosis of MTT and diagnosis of which was confirmed on immunohistochemistry.

5 citations

Journal ArticleDOI
TL;DR: Sudden death is a source of concern and a detailed postmortem examination is mandatory to ascertain its cause and prevention of development of risk factors of atherosclerosis at an early age can be an effective strategy to counter this ailment at all levels.
Abstract: Background: Natural deaths represent a large proportion of sudden (unexpected and unattended) deaths. The term “sudden cardiac death” (SCD) refers to death from the abrupt cessation of cardiac function due to cardiac arrest. The objective of this study was to identify various causes, risk factors, age and sex distribution associated with sudden cardiac death in an Indian setting. Methods: Detail review of medical records and an autopsy study of all cases of sudden cardiac death that occurred instantaneously or within 24 hours of onset of symptoms in a tertiary care institution, between December 2010 and December 2015 was carried out. Results: In total, 124 cases of sudden death were studied during this period. Out of 124 cases, 109 cases (87.90%) showed pathology in heart and aorta. Atherosclerotic coronary heart disease was the most common cause of death (72.58%) followed by Hypertensive heart disease (4.83%), Hypertrophic cardiomyopathy (3.22%), Myocarditis (3.22%), Infective endocarditis (1.61%), Rheumatic heart disease (0.8%), Aortic dissection (0.8%), and syphilitic aortitis (0.8%). Conclusions: Sudden death is a source of concern and a detailed postmortem examination is mandatory to ascertain its cause. Presence of co-existing conditions like diabetes and hypertension contribute immensely to the risk of sudden death. Occurrence of sudden death at a younger age presents a formidable challenge. Prevention of development of risk factors of atherosclerosis at an early age can be an effective strategy to counter this ailment at all levels.

4 citations


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Journal ArticleDOI
TL;DR: Histopathological evaluation of endometrial samples is especially indicated in women over the age of 35 years to rule out malignancy and preneoplasia in patients presenting with AUB.
Abstract: Background: Abnormal uterine bleeding (AUB) is a common gynecological complaint associated with considerable morbidity and significantly affects the patient's family, personal and social life. The aim of the study was to analyze the histomorphological patterns of endometrium in patients presenting with AUB and also to determine the incidence of AUB in various age groups. Materials and Methods: This is a prospective study, conducted in the Department of Pathology, in a tertiary care teaching hospital, Mangalore from October 2011 till date. All cases of AUB with a probable endometrial cause were included in the study. Data was entered in Microsoft Excel and managed in Statistical Package for the Social Sciences (SPSS) version 16. Analysis was done in the form of percentages and proportions and represented as tables where necessary. Results: A total of 156 cases were analyzed. Patients' age ranged from 23-78 years. AUB was most prevalent in the perimenopausal age group. The most common presenting complaint was menorrhagia (47%). Endometrial hyperplasia was the most common histopathological finding and was seen in 25% patients, followed by secretory endometrium in 16.7% patients, and proliferative phase pattern and disordered proliferative endometrium were seen in 12.2% patients each. Malignancy was detected in 6.4% of cases and endometrial carcinoma was the most common lesion (4.5%). Conclusions: Histopathological evaluation of endometrial samples is especially indicated in women over the age of 35 years to rule out malignancy and preneoplasia. Among the patients with no organic pathology, normal physiological patterns with proliferative, secretory, and menstrual changes were observed. The most common endometrial pathology in this series was endometrial hyperplasia.

34 citations

Journal ArticleDOI
TL;DR: The study revealed the highest incidence of AUB in the perimenopausal age group (41-50 years) and recommended a thorough histopathological workup and clinical correlation are mandatory in cases of abnormal uterine bleeding.
Abstract: Background: Abnormal uterine bleeding (AUB) interferes with the quality of life of an otherwise healthy woman. Until the pathology underlying menorrhagia is, accurately diagnosed, proper therapy is hardly possible. The objective of the study was to analyze different histopathological patterns of endometrium in AUB and observe the incidence of various pathologies in different age groups and their relation to parity.Methods: This two-year prospective studywas done in the department of pathology in atertiary care centre, which included 250 cases of clinically diagnosed AUB patients were evaluated. Histopathological examination of endometrial biopsies and hysterectomy specimens were done, followed by clinical correlation.Results: Out of 250 cases of AUB, Premenopausal bleeding was seen in 216 cases (86.4%) and 34 cases (13.6%) had postmenopausal bleeding. The commonest finding observed in the study was proliferative phase endometrium (37.2%), followed by secretory endometrium (34%) and endometrial hyperplasia (16%). Disordered proliferative endometrium was seen in 2.4% of patients. Endometrial carcinoma was seen in 4 (1.6%) cases. Endometrial hyperplasia was seen mostly in the age group 41-50 years (27 cases). Two cases of endometrial carcinomas were presented after age 60 years.Conclusions: Our study revealed the highest incidence of AUB in the perimenopausal age group (41-50 years). Hence a thorough histopathological workup and clinical correlation are mandatory in cases of abnormal uterine bleeding.

15 citations

01 Jan 2014
TL;DR: Histopathological examination of endometrial biopsy is a major diagnostic tool in evaluation of abnormal uterine bleeding (abnormal uterus bleeding) and a specific diagnosis could help the gynaecologist to plan therapy for successful management of abnormal uterus bleeding.
Abstract: This study was conducted in 400 cases of endometrium in women of all age groups. The mean age of women presenting with abnormal uterine bleeding was 41 years. normal physiological changes of menstrual cycle, seen as proliferative and secretory phases of endometrium, were the most common histological findings present in 287 cases (71.75%). benign lesions were found in 19% cases followed by precursor lesions in 4.75% cases and malignant lesions in 4.5% cases. Histopathological examination of endometrial biopsy is a major diagnostic tool in evaluation of abnormal uterine bleeding (abnormal uterine bleeding) and a specific diagnosis could help the gynaecologist to plan therapy for successful management of abnormal uterine bleeding.

11 citations

Journal ArticleDOI
01 Jul 2019
TL;DR: Histopathological evaluation of endometrium helps to exclude the local causes and establishes the diagnosis of dysfunctional uterine bleeding, its types, and clinical correlation to histopathological findings and finally helps to determine the mode of management.
Abstract: Background: Abnormal uterine bleeding (AUB) is one of the most common gynecologic presentations. The present study was conducted to assess clinical and pathological dysfunction uterine bleeding in females. Materials & Methods: The present study was conducted on 82 females reported with uterine bleeding. Endometrial tissue obtained by Dilatation and Curettage was immediately kept in 10% formalin and subjected to histopathology. Time of endometrial biopsy was taken after 15 days from the last menstrual period. Results: Out of 82 females, menorrhagia was seen in 38, menorrhagia in 2, polymenorrhea in 16, oligomenorrhoea in 20, polymenorrhagia in 6. The difference was significant (P

9 citations

Journal ArticleDOI
TL;DR: The histology of MPNSTs is very heterogeneous, showing no specific diagnostic immunoprofile or genetic alteration, so it is important to rule out other histologically similar tumors, particularly in cases arising in uncommon locations or tumors with divergent heterologous differentiation.
Abstract: We report two cases of malignant peripheral nerve sheath tumor (MPNST) in an uncommon location (heart and retropharynx) both with divergent osseous heterologous differentiation. We present the pathological and immunohistochemical studies that confirmed the neurogenic origin. The histopathology of the tumor arising in the retropharynx showed a transition from a neurofibroma to MPNST, making this a new report of an MPNST arising from a plexiform neurofibroma without neurofibromatosis. Primary cardiac MPNST with osseous differentiation has never been reported before. In conclusion, the histology of MPNSTs is very heterogeneous, showing no specific diagnostic immunoprofile or genetic alteration. Thus, it is important to rule out other histologically similar tumors, particularly in cases arising in uncommon locations or tumors with divergent heterologous differentiation.

7 citations