Q
Qi Chen
Researcher at Victoria University of Wellington
Publications - 201
Citations - 7924
Qi Chen is an academic researcher from Victoria University of Wellington. The author has contributed to research in topics: Symbolic regression & Genetic programming. The author has an hindex of 36, co-authored 179 publications receiving 6403 citations. Previous affiliations of Qi Chen include Chinese Academy of Sciences & University of Kansas.
Papers
More filters
Journal ArticleDOI
Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues
Qi Chen,Michael Graham Espey,Murali C. Krishna,James B. Mitchell,Christopher Corpe,Garry R. Buettner,Emily Shacter,Mark Levine +7 more
TL;DR: Human pharmacokinetics data indicate that ascorbate at concentrations achieved only by i.v. administration may be a pro-drug for formation of H(2)O(2), and that blood can be a delivery system of the pro- drug to tissues.
Journal ArticleDOI
Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice.
Qi Chen,Michael Graham Espey,Andrew Y. Sun,Chaya Pooput,Kenneth L. Kirk,Murali C. Krishna,Deena Beneda Khosh,Jeanne Drisko,Mark Levine +8 more
TL;DR: It is shown that ascorbate at pharmacologic concentrations was a prooxidant, generating hydrogen-peroxide-dependent cytotoxicity toward a variety of cancer cells in vitro without adversely affecting normal cells, and this action may have benefits in cancers with poor prognosis and limited therapeutic options.
Journal ArticleDOI
Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo.
Qi Chen,Michael Graham Espey,Andrew Y. Sun,Je-Hyuk Lee,Murali C. Krishna,Emily Shacter,Peter L. Choyke,Chaya Pooput,Kenneth L. Kirk,Garry R. Buettner,Mark Levine +10 more
TL;DR: The data show that pharmacologic ascorbate is a prodrug for preferential steady-state formation of Asc•− and H2O2 in the extracellular space but not blood, which provides a foundation for pursuing pharmacological ascorBate as a prooxidant therapeutic agent in cancer and infections.
Journal ArticleDOI
Isolation and Characterization of Porcine Epidemic Diarrhea Viruses Associated with the 2013 Disease Outbreak among Swine in the United States
Qi Chen,Ganwu Li,Judith A. Stasko,Joseph T. Thomas,Wendy R. Stensland,Angela Pillatzki,Phillip C. Gauger,Kent Schwartz,Darin M. Madson,Kyoung-Jin Yoon,Gregory W. Stevenson,Eric R. Burrough,Karen M. Harmon,Rodger Main,Jianqiang Zhang +14 more
TL;DR: Two PEDV isolates are described, successfully obtained from the small intestines of piglets from sow farms in Indiana and Iowa, respectively, which were genetically closely related to each other and were most genetically similar to Chinese strains reported in 2011 to 2012.
Journal ArticleDOI
High-Dose Parenteral Ascorbate Enhanced Chemosensitivity of Ovarian Cancer and Reduced Toxicity of Chemotherapy
TL;DR: Investigation of the use of intravenous ascorbic acid in conjunction with chemotherapy for ovarian cancer, starting from preclinical models and culminating in a human trial, which demonstrated a significant reduction in chemotherapy-induced adverse effects in patients receiving asCorbate.