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Qi Chen
Researcher at Academy of Military Medical Sciences
Publications - Â 26
Citations - Â 2513
Qi Chen is an academic researcher from Academy of Military Medical Sciences. The author has contributed to research in topics: Monoclonal antibody & Epitope. The author has an hindex of 11, co-authored 23 publications receiving 1376 citations.
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Journal ArticleDOI
Adaptation of SARS-CoV-2 in BALB/c mice for testing vaccine efficacy.
Hongjing Gu,Qi Chen,Guan Yang,Lei He,Hang Fan,Yong Qiang Deng,Yanxiao Wang,Yue Teng,Zhongpeng Zhao,Yujun Cui,Li Yuchang,Xiaofeng Li,Jiangfan Li,Na Na Zhang,Xiaolan Yang,Shaolong Chen,Yan Guo,Guangyu Zhao,Xiliang Wang,De Yan Luo,Hui Wang,Xiao Yang,Yan Li,Gencheng Han,Yuxian He,Xiaojun Zhou,Shusheng Geng,Xiaoli Sheng,Shibo Jiang,Shihui Sun,Cheng-Feng Qin,Yusen Zhou +31 more
TL;DR: A mouse model in which a SARS-CoV-2 strain was infectious and could cause an inflammatory response and moderate pneumonia is developed, and a panel of adaptive mutations potentially associated with the increased virulence are revealed.
Journal ArticleDOI
A Mouse Model of SARS-CoV-2 Infection and Pathogenesis.
Shi Hui Sun,Qi Chen,Hong Jing Gu,Guan Yang,Yan Xiao Wang,Xing Yao Huang,Su Su Liu,Na Na Zhang,Xiaofeng Li,Rui Xiong,Yan Guo,Yong Qiang Deng,Weijin Huang,Quan Liu,Quan Ming Liu,Yue Lei Shen,Yong Zhou,Xiao Yang,Tong Yan Zhao,Chang Fa Fan,Yu Sen Zhou,Cheng-Feng Qin,You Chun Wang +22 more
TL;DR: This animal model, generated using CRISPR/Cas9 knock-in technology, provides a useful tool for studying SARS-CoV-2 transmission and pathogenesis, and evaluating COVID-19 vaccines and therapeutics.
Journal ArticleDOI
A Thermostable mRNA Vaccine against COVID-19.
Na Na Zhang,Xiaofeng Li,Yong Qiang Deng,Hui Zhao,Yi Jiao Huang,Guan Yang,Weijin Huang,Peng Gao,Chao Zhou,Rong Rong Zhang,Yan Guo,Shi Hui Sun,Hang Fan,Shu Long Zu,Qi Chen,Qi He,Tian Shu Cao,Xing Yao Huang,Hong Ying Qiu,Jian Hui Nie,Yuhang Jiang,Hua Yuan Yan,Qing Ye,Xia Zhong,Xia Lin Xue,Zhen Yu Zha,Dongsheng Zhou,Xiao Yang,You Chun Wang,Bo Ying,Cheng-Feng Qin +30 more
TL;DR: A lipid-nanoparticle-encapsulated mRNA (mRNA-LNP) encoding the receptor binding domain (RBD) of SARS-CoV-2 as a vaccine candidate (termed ARCoV) is developed and is currently being evaluated in phase 1 clinical trials.
Journal ArticleDOI
Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody
Zhe Lv,Yong-Qiang Deng,Qing Ye,Lei Cao,Chun Yun Sun,Changfa Fan,Weijin Huang,Shihui Sun,Yao Sun,Ling Zhu,Qi Chen,Nan Wang,Jianhui Nie,Zhen Cui,Dandan Zhu,Neil Shaw,Xiaofeng Li,Qianqian Li,Liangzhi Xie,Youchun Wang,Zihe Rao,Cheng-Feng Qin,Xiangxi Wang +22 more
TL;DR: A humanized monoclonal antibody, H014, is reported that efficiently neutralizes SARS-CoV-2 and SARS -CoV pseudoviruses as well as authentic Sars-Cov-2 at nanomolar concentrations by engaging the spike (S) receptor binding domain (RBD).
Journal ArticleDOI
Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids.
Yan-Peng Xu,Yang Qiu,Boya Zhang,Guilai Chen,Qi Chen,Miao Wang,Fan Mo,Jiuyue Xu,Jin Wu,Rong-Rong Zhang,Rong-Rong Zhang,Meng-Li Cheng,Meng-Li Cheng,Na-Na Zhang,Bao Lyu,Bao Lyu,Wenliang Zhu,Menghua Wu,Qing Ye,Da Zhang,Jianghong Man,Xiaofeng Li,Jie Cui,Zhiheng Xu,Baoyang Hu,Xi Zhou,Xi Zhou,Cheng-Feng Qin,Cheng-Feng Qin +28 more
TL;DR: It is shown that ZIKV infection triggers the abundant production of virus-derived small interfering RNAs in hNPCs, but not in the more differentiated progenies or somatic cells, and enoxacin, a broad-spectrum antibiotic that is known as an RNAi enhancer, exerts potent anti-ZIKV activity in hnPCs and other RNAi-competent cells.