Q
Qian Zhao
Researcher at Huazhong University of Science and Technology
Publications - 21
Citations - 636
Qian Zhao is an academic researcher from Huazhong University of Science and Technology. The author has contributed to research in topics: Fluoride & Autophagy. The author has an hindex of 11, co-authored 18 publications receiving 352 citations. Previous affiliations of Qian Zhao include Shanxi Medical University.
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Journal ArticleDOI
Threshold effects of moderately excessive fluoride exposure on children's health: A potential association between dental fluorosis and loss of excellent intelligence.
Xingchen Yu,Jingwen Chen,Yonggang Li,Hongliang Liu,Changchun Hou,Qiang Zeng,Yushan Cui,Liang Zhao,Pei Li,Ziquan Zhou,Shuo Pang,Sha Tang,Kunming Tian,Qian Zhao,Lixin Dong,Chunyan Xu,Xiao Zhang,Shun Zhang,Li Liu,Aiguo Wang +19 more
TL;DR: The study suggests threshold and saturation effects of moderately excessive fluoride exposure on DF and intelligence loss in children, and a potential association between DF and the loss of excellent intelligence.
Journal ArticleDOI
Excessive apoptosis and defective autophagy contribute to developmental testicular toxicity induced by fluoride.
Shun Zhang,Qiang Niu,Hui Gao,Rulin Ma,Rongrong Lei,Cheng Zhang,Tao Xia,Pei Li,Chunyan Xu,Chao Wang,Jingwen Chen,Lixing Dong,Qian Zhao,Aiguo Wang +13 more
TL;DR: These findings provide deeper insights into roles of excessive apoptosis and defective autophagy in the aggravation of testicular damage, which could contribute to a better understanding of fluoride-induced male reproductive toxicity.
Journal ArticleDOI
Excessive ER stress and the resulting autophagic flux dysfunction contribute to fluoride-induced neurotoxicity.
Qiang Niu,Jingwen Chen,Tao Xia,Pei Li,Guoyu Zhou,Chunyan Xu,Qian Zhao,Lixin Dong,Shun Zhang,Aiguo Wang +9 more
TL;DR: The in vivo results suggest that neuronal death resulted from excessive ER stress and autophagic flux dysfunction contributes to fluoride-elicited neurotoxicity.
Journal ArticleDOI
Thyroid function, intelligence, and low-moderate fluoride exposure among Chinese school-age children
Mengwei Wang,Ling Liu,Huijun Li,Yonggang Li,Hongliang Liu,Changchun Hou,Qiang Zeng,Pei Li,Qian Zhao,Lixin Dong,Guoyu Zhou,Xingchen Yu,Li Liu,Qing Guan,Shun Zhang,Aiguo Wang +15 more
TL;DR: Low-moderate fluoride exposure is associated with alterations in childhood thyroid function that may modify the association between fluoride and intelligence, and a significant modification effect by TSH was detected on the associations between urinary fluoride and IQ scores, without mediation by THs.
Journal ArticleDOI
SIRT1-dependent mitochondrial biogenesis supports therapeutic effects of resveratrol against neurodevelopment damage by fluoride.
Qian Zhao,Zhiyuan Tian,Guoyu Zhou,Guoyu Zhou,Qiang Niu,Jingwen Chen,Pei Li,Lixin Dong,Tao Xia,Shun Zhang,Aiguo Wang +10 more
TL;DR: In vivo and in vitro studies identified RSV, the strongest specific SIRT1 activator, improved mitochondrial biogenesis and subsequent mitochondrial function to protect against developmental fluoride neurotoxicity via activating SIRT2-dependent PGC-1α/NRF1/TFAM signaling pathway.