scispace - formally typeset
Search or ask a question
Author

Qianwen Nie

Bio: Qianwen Nie is an academic researcher from National University of Defense Technology. The author has contributed to research in topics: Coherent diffraction imaging & Medicine. The author has an hindex of 2, co-authored 6 publications receiving 15 citations.

Papers
More filters
Journal ArticleDOI
TL;DR: This work reports coherent imaging of objects behind opaque scattering media with only one piece of the Fourier transform power spectrum pattern under coherent illumination, which extends the methodology of x-ray crystallography to visible-light scattering imaging for underwater and living biomedical imaging.
Abstract: We report coherent imaging of objects behind opaque scattering media with only one piece of the power spectrum pattern. We solve the unique solution and improve algorithm speed for the inverse problem. Based on the proposed scattering-disturbance model, with only one piece of the Fourier transform power spectrum pattern under coherent illumination, we successfully reconstruct clear images of the objects fully hidden by an opaque diffuser. The experimental results demonstrate the feasibility of the reconstruction method and the scattering-disturbance model. Our method makes it possible to carry out snapshot coherent imaging of the objects obscured by scattering media, which extends the methodology of x-ray crystallography to visible-light scattering imaging for underwater and living biomedical imaging.

13 citations

Journal ArticleDOI
TL;DR: The results of spot-size RMS demonstrate that the plastic prism can serve as well as their glass competitors and have better spectral resolution.
Abstract: A direct-vision Amici prism is a desired dispersion element in the value of spectrometers and spectral imaging systems. In this paper, we focus on designing a direct-vision cyclo-olefin-polymer double Amici prism for spectral imaging systems. We illustrate a designed structure: E48R/N-SF4/E48R, from which we obtain 13 deg dispersion across the visible spectrum, which is equivalent to 700 line pairs/mm grating. We construct a simulative spectral imaging system with the designed direct-vision cyclo-olefin-polymer double Amici prism in optical design software and compare its imaging performance to a glass double Amici prism in the same system. The results of spot-size RMS demonstrate that the plastic prism can serve as well as their glass competitors and have better spectral resolution.

2 citations

Patent
15 Mar 2019
TL;DR: In this paper, a phase recovery image reproduction method for lensless imaging is proposed, which requires only one collimated beam-spreading laser, a Fourier lens and a CCD detector, the detected power spectrum is reconstructed in three steps, the first step is to calculate an initial phase by using a hybrid input-output algorithm, soft aperture scanning is then performed, instead of scanning in the target plane and the spatial spectral plane, the second step combines the Ptychography algorithm to enhance the Fourier domain constraints, and uses the phase iterative restoration algorithm to achieve
Abstract: The invention provides a phase recovery image reproduction method for lensless imaging, Fast power spectra were captured by the experimental device of coherent diffraction imaging, the imaging devicerequires only one collimated beam-spreading laser, A Fourier lens and a CCD detector, the detected power spectrum is reconstructed in three steps, the first step is to calculate an initial phase by using a hybrid input-output algorithm, Soft aperture scanning is then performed, instead of scanning in the target plane and the spatial spectral plane, The second step combines the Ptychography algorithm to enhance the Fourier domain constraints, and uses the phase iterative restoration algorithm to achieve the reconstruction of the target image. In the third step, in order to further reduce the normalized root mean square error, the error reduction algorithm is used to reconstruct the target image. The imaging device of the invention is simple, and the algorithm can quickly reconstruct an accurate target image from a power spectrum diagram, thereby realizing the function of image reproduction.

2 citations

Proceedings ArticleDOI
07 Nov 2018
TL;DR: In this paper, a linear model was proposed to restore the hidden object through the actual power spectrum with disturbance of the scattering layer, which quickly converges to the only correct reconstruction solution with the accuracy power spectrum pattern of Fourier transform, and the method can reconstruct the high accuracy image of the object hidden by the scattering media with one shot power spectrum.
Abstract: Under coherent light illumination, several approaches need either angle scanning or diffuser rotating to reconstruct the image through opaque scattering media. We propose a linear model to restore the hidden object through the actual power spectrum with disturbance of the scattering layer. The experimental results confirm that, the algorithm quickly converge to the only correct reconstruction solution with the accuracy power spectrum pattern of Fourier transform, and the method can reconstruct the high accuracy image of the object hidden by the scattering media with one-shot power spectrum.

1 citations

Journal ArticleDOI
TL;DR: Data indicates a MOF-associated epigenetic mechanism in H9c2 cells that promotes attenuation of X-ray radiation-induced injury and may promote the survival of H9C2 cells via inhibition ofMOF-mediated p53K120 acetylation in response to X-Ray radiation- induced apoptosis.
Abstract: Cardiomyocyte apoptosis is involved in the pathogenesis of radiation-induced heart disease, but the underlying epigenetic mechanism remains elusive. We evaluated the potential mediating role of males absent on the first (MOF) in the association between epigenetic activation of p53 lysine 120 (p53K120) and X-ray radiation-induced apoptosis in H9c2 cells. H9c2 cells were pretreated for 24 h with the MOF inhibitor MG149 after 4 Gy irradiation, followed by assessment of cell proliferation, injury, and apoptosis. MOF expression was upregulated by X-ray radiation. MG149 suppressed the proliferation inhibition, reduction of mitochondrial membrane potential, ROS production, and cell apoptosis. MG149 may promote the survival of H9c2 cells via inhibition of MOF-mediated p53K120 acetylation in response to X-ray radiation-induced apoptosis. Our data indicates a MOF-associated epigenetic mechanism in H9c2 cells that promotes attenuation of X-ray radiation-induced injury.

1 citations


Cited by
More filters
Journal ArticleDOI
TL;DR: It is demonstrated that random phase modulation on the optical field, also known as coherent modulation imaging (CMI), in conjunction with the phase extraction neural network (PhENN) and a Gerchberg-Saxton-Fienup (GSF) approximant, further improves resilience to noise of the phase-from-intensity imaging problem.
Abstract: Imaging with low-dose light is of importance in various fields, especially when minimizing radiation-induced damage onto samples is desirable. The raw image captured at the detector plane is then predominantly a Poisson random process with Gaussian noise added due to the quantum nature of photo-electric conversion. Under such noisy conditions, highly ill-posed problems such as phase retrieval from raw intensity measurements become prone to strong artifacts in the reconstructions; a situation that deep neural networks (DNNs) have already been shown to be useful at improving. Here, we demonstrate that random phase modulation on the optical field, also known as coherent modulation imaging (CMI), in conjunction with the phase extraction neural network (PhENN) and a Gerchberg-Saxton-Fienup (GSF) approximant, further improves resilience to noise of the phase-from-intensity imaging problem. We offer design guidelines for implementing the CMI hardware with the proposed computational reconstruction scheme and quantify reconstruction improvement as function of photon count.

29 citations

01 Jul 2011
TL;DR: In this paper, disordered media made of randomly distributed nanoparticles can be used to overcome the diffraction limit of a conventional imaging system, and a method to extract the original image information from the multiple scattering induced by the turbid media is proposed.
Abstract: We report that disordered media made of randomly distributed nanoparticles can be used to overcome the diffraction limit of a conventional imaging system. By developing a method to extract the original image information from the multiple scattering induced by the turbid media, we dramatically increase a numerical aperture of the imaging system. As a result, the resolution is enhanced by more than 5 times over the diffraction limit, and the field of view is extended over the physical area of the camera. Our technique lays the foundation to use a turbid medium as a far-field superlens.

28 citations

Journal ArticleDOI
TL;DR: For photonic devices, structural disorder and light scattering have long been considered annoying and detrimental features that were best avoided or minimized as discussed by the authors , but structural disorder can be harnessed for photonic device applications.
Abstract: For photonic devices, structural disorder and light scattering have long been considered annoying and detrimental features that were best avoided or minimized. This review shows that disorder and complexity can be harnessed for photonic device applications. Compared to ordered systems, disordered systems provide much more possibilities and diverse optical responses. They have been used to create physical unclonable functions for secret key generation, and more recently for random projection, high-dimensional matrix multiplication, and reservoir computing. Incorporating structural disorder enables novel devices with unique functionalities as well as multi-functionality. A random system can function as an optical lens, a spectrometer, a polarimeter, and a radio frequency receiver. It is also employed for optical pulse measurement and full-field recovery. Multi-functional disordered photonic devices have been developed for hyperspectral imaging, spatial, and spectral polarimetry. In addition to passive devices, structural disorder has been incorporated to active devices. One prominent example is the random laser, which enables speckle-free imaging, super-resolution spectroscopy, broad tunability of high-power fiber laser, and suppression of lasing instabilities. Disordered devices have low fabrication costs, and their combination with advanced computational techniques may lead to a paradigm shift in photonics and optical engineering.

24 citations

Proceedings ArticleDOI
22 Jun 2014
TL;DR: In this paper, novel holography-based strategies to overcome these unwanted deviations are discussed in the lecture. But they are limited by highly scattering and absorbing nature of such environments.
Abstract: Imaging within tissues and living organisms at visible wavelengths is limited by highly scattering and absorbing nature of such environments. Novel holography-based strategies to overcome these unwanted deviations will be discussed in the lecture.

11 citations

Journal ArticleDOI
TL;DR: In this paper, the wavelength-dependent speckle multiplexing (WDSM) technique is proposed and demonstrated as an effective method to suppress the interference noise, thereby facilitating the use of partially spatially coherent light as an alternative promising illuminating source.

10 citations