Qihui Wang

TL;DR: The crystal structure of the C-terminal domain of SARS-CoV-2 (SARS- coV- 2-CTD) spike (S) protein in complex with human ACE2 (hACE2) is presented, which reveals a hACE2-binding mode similar overall to that observed for SARS -CoV.

TL;DR: Two monoclonal antibodies isolated from a patient with COVID-19 are shown to interfere with SARS-CoV-2–receptor binding, and one displays potent action against this virus in vitro and in a rhesus macaque model.

TL;DR: In isolation of four human-origin monoclonal antibodies from a convalescent patient, all of which display neutralization abilities, a therapeutic study in a mouse model validated that these antibodies can reduce virus titers in infected lungs.

TL;DR: High-resolution structures of the trimeric MERS- coV and SARS-CoV S proteins in its pre-fusion conformation are presented by single particle cryo-electron microscopy, demonstrating an inherently flexible RBD readily recognized by the receptor.

TL;DR: The crystal structure of the receptor binding domain of the MERS-CoV spike protein, both free and bound to the receptor, was presented in this article, which revealed a core subdomain homologous to that of the SARS-coV spike proteins, and a unique strand-dominated external receptor binding motif that recognizes blades IV and V of the CD26 β-propeller.