Q
Qin Su
Researcher at University of Massachusetts Medical School
Publications - 60
Citations - 2485
Qin Su is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Gene delivery & Adeno-associated virus. The author has an hindex of 22, co-authored 58 publications receiving 1931 citations.
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Journal ArticleDOI
Several rAAV Vectors Efficiently Cross the Blood–brain Barrier and Transduce Neurons and Astrocytes in the Neonatal Mouse Central Nervous System
Hongwei Zhang,Bin Yang,Xin Mu,Xin Mu,Seemin Seher Ahmed,Qin Su,Ran He,Hongyan Wang,Christian Mueller,Miguel Sena-Esteves,Robert H. Brown,Zuoshang Xu,Guangping Gao +12 more
TL;DR: The rAAVs that achieve stable widespread gene transfer in the CNS are exceptionally useful platforms for the development of therapeutic approaches for neurological disorders affecting large regions of the CNS as well as convenient biological tools for neuroscience research.
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Long-term, efficient inhibition of microRNA function in mice using rAAV vectors
Jun Xie,Stefan L. Ameres,Stefan L. Ameres,Randall H. Friedline,Jui-Hung Hung,Jui-Hung Hung,Yu Zhang,Yu Zhang,Qing Xie,Qing Xie,Li Zhong,Qin Su,Ran He,Mengxin Li,Huapeng Li,Xin Mu,Hongwei Zhang,Jennifer A. Broderick,Jason K. Kim,Zhiping Weng,Terence R. Flotte,Phillip D. Zamore,Guangping Gao +22 more
TL;DR: In this paper, the authors combined recombinant adeno-associated virus (rAAV) vectors with miRNA 'tough decoys' (TuDs) to inhibit specific miRNAs.
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Global CNS transduction of adult mice by intravenously delivered rAAVrh.8 and rAAVrh.10 and nonhuman primates by rAAVrh.10.
Bin Yang,Bin Yang,Shaoyong Li,Hongyan Wang,Yansu Guo,Yansu Guo,Dominic J. Gessler,Dominic J. Gessler,Chunyan Cao,Chunyan Cao,Qin Su,Joshua A. Kramer,Li Zhong,Seemin Seher Ahmed,Hongwei Zhang,Hongwei Zhang,Ran He,Ronald C. Desrosiers,Robert H. Brown,Zuoshang Xu,Guangping Gao,Guangping Gao +21 more
TL;DR: The results indicate that rAAVrh.8, along with rh.10 and 9, hold the best promise for developing novel therapeutic strategies to treat neurological diseases in the adult patient population.
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MicroRNA-regulated, systemically delivered rAAV9: A step closer to CNS-restricted transgene expression
Jun Xie,Qing Xie,Qing Xie,Hongwei Zhang,Stefan L. Ameres,Jui-Hung Hung,Qin Su,Ran He,Xin Mu,Seemin Seher Ahmed,Soyeon Park,Hiroki Kato,Chengjian Li,Christian Mueller,Craig C. Mello,Zhiping Weng,Terence R. Flotte,Phillip D. Zamore,Guangping Gao +18 more
TL;DR: This approach allowed simultaneous multi-tissue regulation and CNS-directed stable transgene expression without detectably perturbing the endogenous miRNA pathway, and promise to facilitate the development of miRNA-regulated rAAV for CNS-targeted gene delivery and other applications.
Journal ArticleDOI
Increased CRF signalling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal
Rubing Zhao-Shea,Steven R. DeGroot,Liwang Liu,Markus Vallaster,Xue-Yan Pang,Qin Su,Guangping Gao,Oliver J. Rando,Gilles E. Martin,Olivier George,Paul D. Gardner,Andrew R. Tapper +11 more
TL;DR: It is shown that withdrawal-induced anxiety increases activity of neurons in the interpeduncular intermediate (IPI), a subregion of the interpinguncular nucleus (IPN), and increased CRF receptor signaling within a VTA-IPN-MHb circuit triggers anxiety during nicotine withdrawal.