Qingbao Gong

Bio: Qingbao Gong is an academic researcher from Anhui Normal University. The author has contributed to research in topics: BODIPY & Fluorescence. The author has an hindex of 4, co-authored 10 publications receiving 57 citations.

The main strategies for tuning BODIPY fluorophores into photosensitizers

Abstract: Photodynamic therapy (PDT) is a minimally invasive technique for the treatment of target malignant tumors via the generation of highly reactive singlet oxygen species. PDT treatment of cancer/tumor...

β-AlkenylBODIPY Dyes: Regioselective Synthesis via Oxidative C-H Olefination, Photophysical Properties, and Bioimaging Studies.

Abstract: A series of 2-alkenyl- and 2,6-dialkenylboron dipyrromethene (BODIPY) derivatives were synthesized through Pd(II)-catalyzed regioselective and stereoselective oxidative C–H olefination in one step. The 2-alkenyl BODIPY derivative further reacted with various amines regioselectively at the 5-position through direct oxidative nucleophilic substitution. The photophysical properties of the 2-alkenyl- and 2,6-dialkenyl-substituted BODIPYs were investigated, which showed great potential in fluorescent bioimaging.

Principles Of Fluorescence Spectroscopy

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BODIPY-Based Photodynamic Agents for Exclusively Generating Superoxide Radical over Singlet Oxygen.

Abstract: Developing Type-I photosensitizers is considered as an efficient approach to overcome the deficiency of traditional photodynamic therapy (PDT) for hypoxic tumors. However, it remains a challenge to design photosensitizers for generating reactive oxygen species by the Type-I process. Herein, we report a series of α,β-linked BODIPY dimers and a trimer that exclusively generate superoxide radical (O2-. ) by the Type-I process upon light irradiation. The triplet formation originates from an effective excited-state relaxation from the initially populated singlet (S1 ) to triplet (T1 ) states via an intermediate triplet (T2 ) state. The low reduction potential and ultralong lifetime of the T1 state facilitate the efficient generation of O2-. by inter-molecular charge transfer to molecular oxygen. The energy gap of T1 -S0 is smaller than that between 3 O2 and 1 O2 thereby precluding the generation of singlet oxygen by the Type-II process. The trimer exhibits superior PDT performance under the hypoxic environment.

J-aggregates of meso-[2.2]paracyclophanyl-BODIPY dye for NIR-II imaging.

Abstract: J-aggregation is an efficient strategy for the development of fluorescent imaging agents in the second near-infrared window. However, the design of the second near-infrared fluorescent J-aggregates is challenging due to the lack of suitable J-aggregation dyes. Herein, we report meso-[2.2]paracyclophanyl-3,5-bis-N,N-dimethylaminostyrl BODIPY (PCP-BDP2) as an example of BODIPY dye with J-aggregation induced the second near-infrared fluorescence. PCP-BDP2 shows an emission maximum at 1010 nm in the J-aggregation state. Mechanism studies reveal that the steric and conjugation effect of the PCP group on the BODIPY play key roles in the J-aggregation behavior and photophysical properties tuning. Notably, PCP-BDP2 J-aggregates can be utilized for lymph node imaging and fluorescence-guided surgery in the nude mouse, which demonstrates their potential clinical application. This study demonstrates BODIPY dye as an alternate J-aggregation platform for developing the second near-infrared imaging agents. J-aggregation has been proved to be an efficient strategy for the development of fluorescent imaging agents in the NIR-II spectral region but the design of appropriate J-aggregates is challenging. Here, the authors demonstrate J-aggregation of a BODIPY dye with NIR-II emission and demonstrate lymph node imaging for fluorescence guided surgery.

Aromatic [b]-fused BODIPY dyes as promising near-infrared dyes.

Abstract: Far-red and near-infrared (NIR) absorbing/emitting dyes have found diverse applications in biomedicine and material science. However, the absorption and emission of classical BODIPY chromophores at short wavelength hamper their applications. Several strategies have been adopted to modify the structure of the BODIPY core to design NIR dyes. Among these, the most efficient approach to expand the π-conjugation of the BODIPY core is via fusion of aromatic rings. So far, many novel BODIPY skeletons fused to aromatic hydrocarbons and heterocycles at the b bond have been reported. This review comprehensively describes the recent advances regarding the development of aromatic [b]-fused BODIPY dyes with the focus on the design and synthesis, the relationships between their photophysical/spectroscopic properties and molecular structures, and the potential applications in bioassays and optoelectronic devices.

Near-infrared dyes for two-photon absorption in the short-wavelength infrared: strategies towards optical power limiting

Abstract: This work provides an overview of the recent advances in the field of two-photon absorbing chromophores active in the short-wavelength infrared (SWIR) spectral range. Herein the common strategies and main structure–property relationships that lead to near-infrared (NIR) electronic absorption of chromophores are described. A complete review of the molecules that feature two-photon absorption (2PA) beyond 1100 nm is presented for the purpose of further use in optical power limiting applications in the SWIR band. Recent progress in the development of optical power limiting in this particular spectral region is reported with emphasis on the use of the two-photon induced excited state absorption (ESA) process as an optical power limiting enhancer.