Q
Qingfeng Chen
Researcher at Agency for Science, Technology and Research
Publications - 80
Citations - 3861
Qingfeng Chen is an academic researcher from Agency for Science, Technology and Research. The author has contributed to research in topics: Immune system & Humanized mouse. The author has an hindex of 27, co-authored 79 publications receiving 2844 citations. Previous affiliations of Qingfeng Chen include University of Science and Technology of China & Massachusetts Institute of Technology.
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Journal ArticleDOI
Mapping the human DC lineage through the integration of high-dimensional techniques
Peter See,Charles-Antoine Dutertre,Charles-Antoine Dutertre,Jinmiao Chen,Patrick Günther,Naomi McGovern,Sergio Erdal Irac,Merry Gunawan,Marc Beyer,Marc Beyer,Kristian Händler,Kaibo Duan,Hermi Sumatoh,Nicolas Ruffin,Mabel Jouve,Ester Gea-Mallorquí,Raoul C.M. Hennekam,Tony Kiat Hon Lim,Chan Chung Yip,Ming Wen,Benoit Malleret,Benoit Malleret,Ivy Low,Nurhidaya Binte Shadan,Charlene Foong Shu Fen,Alicia Tay,Josephine Lum,Francesca Zolezzi,Anis Larbi,Michael Poidinger,Jerry Kok Yen Chan,Qingfeng Chen,Laurent Rénia,Muzlifah Haniffa,Philippe Benaroch,Andreas Schlitzer,Andreas Schlitzer,Joachim L. Schultze,Joachim L. Schultze,Evan W. Newell,Florent Ginhoux +40 more
TL;DR: Two unbiased high-dimensional technologies are employed to characterize the human DC lineage from bone marrow to blood and provide new markers that can be used to identify unambiguously pre-DC from pDC, including CD33, CX3CR1, CD2, CD5, and CD327.
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Efficient Endoderm Induction from Human Pluripotent Stem Cells by Logically Directing Signals Controlling Lineage Bifurcations
Kyle M. Loh,Kyle M. Loh,Lay Teng Ang,Jingyao Zhang,Vibhor Kumar,Jasmin Ang,Jun Qiang Auyeong,Kian Leong Lee,Siew Hua Choo,Christina Ying Yan Lim,Massimo Nichane,Junru Tan,Monireh Soroush Noghabi,Lisa Azzola,Elizabeth Ng,Elizabeth Ng,Jens Durruthy-Durruthy,Vittorio Sebastiano,Lorenz Poellinger,Andrew G. Elefanty,Andrew G. Elefanty,Edouard G. Stanley,Edouard G. Stanley,Qingfeng Chen,Qingfeng Chen,Qingfeng Chen,Shyam Prabhakar,Irving L. Weissman,Bing Lim,Bing Lim,Bing Lim +30 more
TL;DR: Comprehensive transcriptional and chromatin mapping of highly pure endoderm populations revealed that endodermal enhancers existed in a surprising diversity of "pre-enhancer" states before activation, reflecting the establishment of a permissive chromatin landscape as a prelude to differentiation.
Journal ArticleDOI
Interaction between tumour-infiltrating B cells and T cells controls the progression of hepatocellular carcinoma
Marta Garnelo,Alex Tan,Zhisheng Her,Joe Yeong,Joe Yeong,Chun Jye Lim,Jinmiao Chen,Kiat Hon Lim,Achim Weber,Pierce K. H. Chow,Pierce K. H. Chow,Alexander Y. F. Chung,London Lucien Pj Ooi,London Lucien Pj Ooi,Han Chong Toh,Mathias Heikenwalder,Irene Oi-Lin Ng,Alessandra Nardin,Qingfeng Chen,Jean-Pierre Abastado,Valerie Chew,Valerie Chew,Valerie Chew +22 more
TL;DR: The close proximity of tumour-infiltrating T cells and B cells indicates a functional interaction between them that is linked to an enhanced local immune activation and contributes to better prognosis for patients with HCC.
Journal ArticleDOI
Expression of human cytokines dramatically improves reconstitution of specific human-blood lineage cells in humanized mice
TL;DR: Human cytokine gene expression by hydrodynamic delivery is a simple and efficient method to improve reconstitution of specific human-blood cell lineages in humanized mice, providing an important tool for studying human immune responses and disease progression in a small animal model.
Journal ArticleDOI
Generation of Human PSC-Derived Kidney Organoids with Patterned Nephron Segments and a De Novo Vascular Network
Jian Hui Low,Pin Li,Elaine Guo Yan Chew,Elaine Guo Yan Chew,Bingrui Zhou,Keiichiro Suzuki,Tian Zhang,Michelle M. Lian,Michelle M. Lian,Meng Liu,Emi Aizawa,Concepcion Rodriguez Esteban,Kylie Su Mei Yong,Qingfeng Chen,Qingfeng Chen,Josep M. Campistol,Mingliang Fang,Chiea Chuen Khor,Jia Nee Foo,Jia Nee Foo,Juan Carlos Izpisua Belmonte,Yun Xia +21 more
TL;DR: A versatile protocol for generating vascularized three-dimensional kidney organoids and establishes an in-vitro model of autosomal recessive polycystic kidney disease (ARPKD), the cystic phenotype of which can be effectively prevented by gene correction or drug treatment.