Author
Qingfeng Liu
Other affiliations: Second Military Medical University
Bio: Qingfeng Liu is an academic researcher from Henan Normal University. The author has contributed to research in topics: Quenching (fluorescence) & Intramolecular force. The author has an hindex of 22, co-authored 99 publications receiving 1342 citations. Previous affiliations of Qingfeng Liu include Second Military Medical University.
Papers published on a yearly basis
Papers
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TL;DR: In this article, the reduction of carbonyl compounds to alcohols with ammonia borane (AB), a nontoxic, environmentally benign, and easily handled reagent, in neat water was achieved in quantitative conversions and high isolated yields.
75 citations
TL;DR: Results suggest that the ISFI is a suitable system for controlled release of Talpha1 and significantly increased the thymic index and spleen index of immunosuppressive mice.
74 citations
TL;DR: An efficient and Brønsted acid free one-pot protocol to directly generate structurally sophisticated α-formylpyrrole derivatives in moderate to good yields has been demonstrated, involving an iron-mediated domino oxidation/formylation reaction of readily available 2,3-dihydro-1H-pyrroles in dimethyl sulfoxide and air atmosphere.
Abstract: An efficient and Bronsted acid free one-pot protocol to directly generate structurally sophisticated α-formylpyrrole derivatives in moderate to good yields has been demonstrated, involving an iron-mediated domino oxidation/formylation reaction of readily available 2,3-dihydro-1H-pyrroles in dimethyl sulfoxide and air atmosphere, in which dimethyl sulfoxide acts as the formyl donor. A possible mechanism is presented.
71 citations
TL;DR: In this paper, a novel glycal-based O-glycosylation reaction, in which the substrates are not only peracetyl glycals but also perbenzyl glucals to afford the corresponding 2,3-unsaturated-O-glucosides via Ferrier rearrangement, was developed.
66 citations
TL;DR: In this article, a simple copper promoting system was proposed to efficiently promote Glaser coupling reaction under ambient temperature, and the successful application of the CuI/NBS/DIPEA promoting system in sugar and amino acid-building blocks indicated the potential of this method in the construction of designed sugar and peptide biomolecules.
65 citations
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1,358 citations
TL;DR: This review concludes that Etherification without Cyclization and N-Alkylation should be considered as separate science, and the proposed treatment of Etherification with Cyclization as a separate science should be reconsidered.
Abstract: 10. Patented Literature 2616 10.1. Esterification 2616 10.2. Ether Formation 2619 10.2.1. Etherification without Cyclization 2619 10.2.2. Etherification with Cyclization 2624 10.3. N-Alkylation 2625 10.4. Other Reactions 2627 11. Summary and Outlook 2628 12. Note Added in Proof 2628 13. Abbreviations Used in This Review 2629 14. Acknowledgments 2629 15. Supporting Information Available 2630 16. References 2630
909 citations
TL;DR: This tutorial review summarises recent progress in the development of novel and practical iron-catalysed reactions with a particular focus on those which provide access to new carbon-heteroatom and heteroatom-heteroa linkages.
Abstract: Given its ready availability, low price and environmentally friendly character, iron is an attractive and often advantageous alternative to other transition metals in the field of catalysis. This tutorial review summarises recent progress in the development of novel and practical iron-catalysed reactions with a particular focus on those which provide access to new carbon–heteroatom and heteroatom–heteroatom linkages. It shall be of interest for both the academic as well as the industrial community.
901 citations
636 citations
TL;DR: In this paper, a review of microneedle arrays can increase the number of compounds amenable to transdermal delivery by penetrating the skin's protective barrier, the stratum corneum, and creating a pathway for drug permeation to the dermal tissue below.
Abstract: Transdermal drug delivery offers a number of advantages for the patient, due not only its non-invasive and convenient nature, but also factors such as avoidance of first pass metabolism and prevention of gastrointestinal degradation. It has been demonstrated that microneedle arrays can increase the number of compounds amenable to transdermal delivery by penetrating the skin's protective barrier, the stratum corneum , and creating a pathway for drug permeation to the dermal tissue below. Microneedles have been extensively investigated in recent decades for drug and vaccine delivery as well as minimally invasive patient monitoring/diagnosis. This review focuses on a range of critically important aspects of microneedle technology, namely their material composition, manufacturing techniques, methods of evaluation and commercial translation to the clinic for patient benefit and economic return. Microneedle research and development is finally now at the stage where commercialisation is a realistic possibility. However, progress is still required in the areas of scaled-up manufacture and regulatory approval.
525 citations