Author
Qingyu Xu
Bio: Qingyu Xu is an academic researcher from Qilu University of Technology. The author has contributed to research in topics: Fluorescence & Cytotoxicity. The author has an hindex of 2, co-authored 5 publications receiving 21 citations.
Papers
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TL;DR: A cancer cell targeted fluorescent Viscosity probe has been designed and synthesized to specifically visualise viscosity changes in biotin receptor (BiR) positive cells over biotin negative cells via dual-mode fluorescence imaging: fluorescence intensity mode and fluorescence lifetime mode.
43 citations
TL;DR: This work presents a fluorescent probe (D-CN) that can offer fluorescence imaging of H2S and copper (II) ions with different response signals, and visually proves that the cytotoxicity of copper ions in living cells increases in the presence of hydrogen sulfide and could lead to cell apoptosis.
19 citations
TL;DR: Li et al. as mentioned in this paper developed a biotin-guided two-photon fluorescent probe (BT-HP) for sensitive detection of H2O2 in cancer cells, which can selectively enter cancer cells and perform fluorescence imaging of the hydrogen peroxide in the cancer cells.
19 citations
TL;DR: In this paper, a "turn-on" chitosan-based viscosity fluorescent probe (CS-V) was used for cell-level visco-level measurement.
15 citations
TL;DR: In this article, α-cinnamon group as the lipophilic group and diethylenetriamine group as hydrophilic group were successfully introduced into alkali lignin to construct a Lignin-based amphiphilic cationic surfactant.
10 citations
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TL;DR: In this paper, the state-of-the-art progress of fluorescent probes for visualizing pathophysiological microenvironments (viscosity, pH, and polarity), since 2016, as well as the future perspectives in this challenging field.
Abstract: Abnormal microenvironments (viscosity, polarity, pH, etc.) have been verified to be closely associated with numerous pathophysiological processes such as inflammation, neurodegenerative diseases, and cancer. As a result, deep insights into these pathophysiological microenvironments are particularly beneficial for clinical diagnosis and treatment. However, the monitoring of pathophysiological microenvironments is unattainable by the traditional clinical diagnostic techniques such as magnetic resonance imaging, computed tomography, and positron emission tomography. Recently, fluorescence imaging has shown tremendous advantages and potential in the tracing of pathophysiological microenvironment variations. In this context, a general discussion is provided on the state-of-the-art progress of fluorescent probes for visualizing pathophysiological microenvironments (viscosity, pH, and polarity), since 2016, as well as the future perspectives in this challenging field.
150 citations
TL;DR: In this paper , the authors focused on the design strategies, spectral performance, and biological applications of multifunctional probes for the simultaneous detection of viscosity and analytes which were reported in recent years.
80 citations
TL;DR: In this article , the main constraints affecting industrial lignin valorization, possible solutions and future perspectives, in the light of its abundance and its potential applications reported in the scientific literature are highlighted.
75 citations
TL;DR: In this article, the viscosity-sensitive small molecular fluorescent probes used in bioimaging are comprehensively summarized, mainly focusing on the last three years, and the current challenges and opportunities for the development of visosity-specific fluorescent probes are discussed.
Abstract: Viscosity, as a vital microenvironment parameter, is tightly associated with multitudinous cellular processes and diseases. Recently, precise visualization of viscosity has started to arouse more and more interest. However, owing to the complicated character, it is still a huge challenge to directly observe viscosity in living systems. In this regard, mounting fluorescence probes are being increasingly fabricated to map viscosity inside live cells and small animals. In this minireview, the viscosity-sensitive small molecular fluorescent probes used in bioimaging are comprehensively summarized, mainly focusing on the last three years. Moreover, the current challenges and opportunities for the development of viscosity-specific fluorescent probes will be discussed.
63 citations
TL;DR: In this paper, a mitochondria-targeted near-infrared fluorescent probe NIR-V with 700 nm emission was designed to monitor cell viscosity changes with high selectivity and sensitivity.
49 citations