Author
Qingyun Yang
Other affiliations: Chinese Ministry of Education
Bio: Qingyun Yang is an academic researcher from Peking Union Medical College. The author has contributed to research in topics: Pinocembrin & Chemistry. The author has an hindex of 7, co-authored 33 publications receiving 203 citations. Previous affiliations of Qingyun Yang include Chinese Ministry of Education.
Papers
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TL;DR: Bioassay guided fractionation of Boenninghausenia sessilicarpa resulted in the isolation of a new dimeric coumarin glucoside 9′-methoxyl rutarensin and a cytotoxic compound rutamarin, as well as an antivirus component leptodactylone, together with six known coumarins.
41 citations
TL;DR: Four new chromone glycosides allo-aloeresin D (2) and 8 showed significant inhibitory activity against BACE1 (beta-secretase) with IC (50) values of 39.0 and 20.3 %, respectively, in B103 neuroblastoma cells at 30 ppm.
Abstract: Four new chromone glycosides allo-aloeresin D (2) , C-2'-decoumaroyl-aloeresin G (8), 2'-O-coumaroyl-(S)-aloesinol (9), 2'-O-[ P-methoxy-(E)-cinnamoyl]-(S)-aloesinol (10) and nine known chromone glycosides ( 1, 3 - 7, 11 - 13) were isolated from two Aloe spp. plants, A. vera and A. nobilis. Among them, 1 and 8 showed significant inhibitory activity against BACE1 (beta-secretase) with IC (50) values of 39.0 and 20.5 x 10 (-6) M, as well as inhibition of Abeta (1-42) production by 7.4 and 12.3 %, respectively, in B103 neuroblastoma cells at 30 ppm. The preliminary structure-activity relationships of ALOE chromone glucosides were also discussed.
40 citations
TL;DR: A new triglucosylated naphthalene derivative, named aloveroside A (1), together with two known anthraquinone dimers and two 6-phenyl-2-pyrone derivatives, was isolated from the Aloe vera ethanolic extracts.
22 citations
TL;DR: Bioassay-guided fractionation of the ethanol extract of Senecio scandens led to the isolation of four new compounds 1–4, obtained as tautomeric mixture of α/β epimers, which exhibited moderate cytotoxicities against five tumor cell lines.
20 citations
TL;DR: In this study, the method’s linearity, range, limit of quantification, stability, precision, and accuracy were validated and the results were consistent with those obtained from high-performance liquid chromatography analysis.
Abstract: A simple, rapid, accurate, and selective quantitative nuclear magnetic resonance method for the determination of tadalafil in bulk drugs and its tablets was established and evaluated. Spectra were obtained in dimethylsulfoxide-d6 using 2,4-dinitrotoluene as the internal standard. In this study, the method's linearity, range, limit of quantification, stability, precision, and accuracy were validated. The results were consistent with those obtained from high-performance liquid chromatography analysis. Thus, the proposed method is a useful and practical tool for the determination of tadalafil in bulk drugs and its tablets.
20 citations
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TL;DR: It was noted that the most promising small molecules identified as coronavirus inhibitors contained a conjugated fused ring structure with the majority being classified as being polyphenols.
273 citations
TL;DR: This mini-review aspires to account and present the literature reports published on research concerning various natural and synthetic stilbenes, such as trans-resveratrol, with special focus on most recent research findings.
163 citations
TL;DR: Berberine along with its derivatives or in combination with other pharmaceutically active compounds or in the form of formulations has applications in various therapeutic areas such as cancer, inflammation, diabetes, depression, hypertension, and various infectious areas.
Abstract: Introduction: Berberine, a protoberberine alkaloid, and its derivatives exhibit a wide spectrum of pharmacological activities. It has been used in traditional Chinese medicine and Ayurvedic medicin...
134 citations
TL;DR: A comprehensive review on the natural compounds that interfere with the life cycles of SARS and MERS are provided, and their potential use for the treatment of COVID-19 is discussed.
121 citations
TL;DR: Pinocembrin has potential as a drug to treat ischemic stroke and other clinical conditions and its pharmacologic characteristics are summarized and its mechanisms of action are discussed.
Abstract: Pinocembrin is a natural flavonoid compound extracted from honey, propolis, ginger roots, wild marjoram, and other plants. In preclinical studies, it has shown anti-inflammatory and neuroprotective effects as well as the ability to reduce reactive oxygen species, protect the blood-brain barrier, modulate mitochondrial function, and regulate apoptosis. Considering these pharmaceutical characteristics, pinocembrin has potential as a drug to treat ischemic stroke and other clinical conditions. In this review, we summarize its pharmacologic characteristics and discuss its mechanisms of action and potential therapeutic applications.
105 citations