Q
Qinhua Huang
Researcher at Iowa State University
Publications - 24
Citations - 1265
Qinhua Huang is an academic researcher from Iowa State University. The author has contributed to research in topics: Palladium & Catalysis. The author has an hindex of 11, co-authored 24 publications receiving 1206 citations.
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Journal ArticleDOI
Synthesis of substituted isoquinolines by electrophilic cyclization of iminoalkynes
TL;DR: In this article, the tert-butylimines of o-(1-alkynyl)benzaldehydes and analogous pyridine carbaldehyde have been cyclized under very mild reaction conditions in the presence of I2, ICl, PhSeCl and p-O2NC6H4SCl to give the corresponding halogen-, selenium-, and sulfur-containing disubstituted isoquinolines and naphthyridines, respectively.
Journal ArticleDOI
Pd-catalyzed alkyl to aryl migration and cyclization: an efficient synthesis of fused polycycles via multiple C-H activation.
TL;DR: A novel palladium migration methodology for the synthesis of complex fused polycycles has been developed that involves 1,4-palladium alkyl to aryl migrations via through-space C-H activation, followed by intramolecular arylation or an intermolecular Heck reaction providing a very efficient way to synthesize fused ring systems.
Journal ArticleDOI
1,4-palladium migration via C-H activation, followed by arylation: synthesis of fused polycycles.
TL;DR: A novel palladium migration/arylation methodology for the synthesis of complex fused polycycles has been developed, in which one or more sequential Pd-catalyzed intramolecular migration processes involving C-H activation are employed.
Journal ArticleDOI
Synthesis of 4-(1-alkenyl)isoquinolines by palladium(II)-catalyzed cyclization/olefination.
Qinhua Huang,Richard C. Larock +1 more
TL;DR: The introduction of an o-methoxy group on the arylaldimine promotes the Pd-catalyzed cyclization and stabilizes the resulting Pd(II) intermediate, improving the yields of the isoquinoline products.
Journal ArticleDOI
Synthesis of isoquinolines and naphthyridines by electrophilic ring closure of iminoalkynes.
TL;DR: Substituted isoquinolines and naphthyridines have been prepared in good to excellent yields by the reaction of iminoalkynes with a variety of electrophiles under mild reaction conditions.