Q
Qiongyu Chen
Researcher at Washington University in St. Louis
Publications - 5
Citations - 3144
Qiongyu Chen is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: T cell & Engineering. The author has an hindex of 3, co-authored 3 publications receiving 2240 citations.
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Journal ArticleDOI
Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
Chih-Hao Chang,Jing Qiu,David O’Sullivan,Michael D. Buck,Takuro Noguchi,Jonathan D. Curtis,Qiongyu Chen,Mariel Gindin,Matthew M. Gubin,Gerritje J.W. van der Windt,Elena Tonc,Robert D. Schreiber,Edward J. Pearce,Erika L. Pearce +13 more
TL;DR: It is shown that tumor-imposed metabolic restrictions can mediate T cell hyporesponsiveness during cancer, and it is found that blocking PD-L1 directly on tumors dampens glycolysis by inhibiting mTOR activity and decreasing expression of gly colysis enzymes.
Journal ArticleDOI
Mitochondrial Dynamics Controls T Cell Fate Through Metabolic Programming
Michael D. Buck,Michael D. Buck,David O’Sullivan,Ramon I. Klein Geltink,Jonathan D. Curtis,Chih-Hao Chang,David E. Sanin,Jing Qiu,Jing Qiu,Oliver Kretz,Oliver Kretz,Daniel Braas,Gerritje J.W. van der Windt,Qiongyu Chen,Stanley Ching-Cheng Huang,Christina M. O’Neill,Brian T. Edelson,Edward J. Pearce,Edward J. Pearce,Hiromi Sesaki,Tobias B. Huber,Tobias B. Huber,Angelika S. Rambold,Angelika S. Rambold,Erika L. Pearce +24 more
TL;DR: The data suggest that, by altering cristae morphology, fusion in TM cells configures electron transport chain (ETC) complex associations favoring oxidative phosphorylation (OXPHOS) and FAO, while fission in TE cells leads to cristsae expansion, reducing ETC efficiency and promoting aerobic glycolysis.
Journal ArticleDOI
Type 1 Interferons Induce Changes in Core Metabolism that Are Critical for Immune Function
Duojiao Wu,Duojiao Wu,David E. Sanin,David E. Sanin,Bart Everts,Bart Everts,Qiongyu Chen,Jing Qiu,Jing Qiu,Michael D. Buck,Michael D. Buck,Annette E. Patterson,Amber M. Smith,Chih-Hao Chang,Zhi-Ping Liu,Maxim N. Artyomov,Erika L. Pearce,Erika L. Pearce,Marina Cella,Edward J. Pearce,Edward J. Pearce,Edward J. Pearce +21 more
TL;DR: Findings reveal FAO, OXPHOS and PPARα as potential targets to therapeutically modulate downstream effects of type 1 IFNs.
Journal ArticleDOI
Correlation between Rockwell and Brinell Hardness Measurements
TL;DR: In this article, by testing the hardness of a wide range of materials, the authors show that Rockwell and Brinell hardness tests, the two most used hardness measurements, are closely related.
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Flaw sensitivity of cellulose paper
TL;DR: In this article , the flaw sensitivity of cellulose paper was investigated by measuring the fractocohesive lengths of celluloses made from cellulose fibers with various diameters (from nanometers to microns) and lengths (from sub-microns to millimeters).