R. B. Sharma

Bio: R. B. Sharma is an academic researcher. The author has contributed to research in topics: Diesel fuel & Vibrio cholerae. The author has an hindex of 6, co-authored 9 publications receiving 621 citations.

CFD Simulation for Flow over Passenger Car Using Tail Plates for Aerodynamic Drag Reduction

Abstract: This work proposes an effective numerical model based on the Computational Fluid Dynamics (CFD) approach to obtain the flow structure around a passenger car with Tail Plates. The experimental work of the test vehicle and grid system is constructed by ANSYS-14.0. FLUENT which is the CFD solver & employed in the present work. In this study, numerical iterations are completed, then after aerodynamic data and detailed complicated flow structure are visualized. In the present work, model of generic passenger car has been developed in solid works-10 and generated the wind tunnel and applied the boundary conditions in ANSYS workbench 14.0 platform then after testing and simulation has been performed for the evaluation of drag coefficient for passenger car. In another case, the aerodynamics of the most suitable design of tail plate is introduced and analysedfor the evaluation of drag coefficient for passenger car. The addition of tail plates results in a reduction of the drag-coefficient 3.87% and lift coefficient 16.62% in head-on wind. Rounding the edges partially reduces drag in head-on wind but does not bring about the significant improvements in the aerodynamic efficiency of the passenger car with tail plates, it can be obtained. Hence, the drag force can be reduced by using add on devices on vehicle and fuel economy, stability of a passenger car can be improved.

Drag Reduction of Passenger Car Using Add-On Devices

Abstract: This work proposes an effective numerical model using the Computational Fluid Dynamics (CFD) to obtain the flow structure around a passenger car with different add-on devices. The computational/numerical model of the passenger car and mesh was constructed using ANSYS Fluent which is the CFD solver and employed in the present work. In this study, numerical iterations are completed, and then aerodynamic data and detailed complicated flow structure are visualized. In the present work, a model of generic passenger car was developed using solidworks, generated the wind tunnel, and applied the boundary conditions in ANSYS workbench platform, and then testing and simulation have been performed for the evaluation of drag coefficient for passenger car. In another case, the aerodynamics of the most suitable design of vortex generator, spoiler, tail plates, and spoiler with VGs are introduced and analysed for the evaluation of drag coefficient for passenger car. The addition of these add-on devices are reduces the drag-coefficient and lift coefficient in head-on wind. Rounding the edges partially reduces drag in head-on wind but does not bring about the significant improvements in the aerodynamic efficiency of the passenger car with add-on devices, and it can be obtained. Hence, the drag force can be reduced by using add-on devices on vehicle and fuel economy, stability of a passenger car can be improved.

Global Climate and Infectious Disease: The Cholera Paradigm*

Abstract: The origin of cholera has been elusive, even though scientific evidence clearly shows it is a waterborne disease. However, standard bacteriological procedures for isolation of the cholera vibrio from environmental samples, including water, between epidemics generally were unsuccessful. Vibrio cholerae, a marine vibrio, requiring salt for growth, enters into a dormant, viable but nonculturable stage when conditions are unfavorable for growth and reproduction. The association of Vibrio cholerae with plankton, notably copepods, provides further evidence for the environmental origin of cholera, as well as an explanation for the sporadic and erratic occurrence of cholera epidemics. On a global scale, cholera epidemics can now be related to climate and climatic events, such as El Nino, as well as the global distribution of the plankton host. Remote sensing, with the use of satellite imagery, offers the potential for predicting conditions conducive to cholera outbreaks or epidemics.

Epidemiology, Genetics, and Ecology of Toxigenic Vibrio cholerae

Abstract: Cholera caused by toxigenic Vibrio cholerae is a major public health problem confronting developing countries, where outbreaks occur in a regular seasonal pattern and are particularly associated with poverty and poor sanitation. The disease is characterized by a devastating watery diarrhea which leads to rapid dehydration, and death occurs in 50 to 70% of untreated patients. Cholera is a waterborne disease, and the importance of water ecology is suggested by the close association of V. cholerae with surface water and the population interacting with the water. Cholera toxin (CT), which is responsible for the profuse diarrhea, is encoded by a lysogenic bacteriophage designated CTXΦ. Although the mechanism by which CT causes diarrhea is known, it is not clear why V. cholerae should infect and elaborate the lethal toxin in the host. Molecular epidemiological surveillance has revealed clonal diversity among toxigenic V. cholerae strains and a continual emergence of new epidemic clones. In view of lysogenic conversion by CTXΦ as a possible mechanism of origination of new toxigenic clones of V. cholerae, it appears that the continual emergence of new toxigenic strains and their selective enrichment during cholera outbreaks constitute an essential component of the natural ecosystem for the evolution of epidemic V. cholerae strains and genetic elements that mediate the transfer of virulence genes. The ecosystem comprising V. cholerae, CTXΦ, the aquatic environment, and the mammalian host offers an understanding of the complex relationship between pathogenesis and the natural selection of a pathogen.

Vibrio cholerae and cholera: Out of the water and into the host

Abstract: The facultative human pathogen Vibrio cholerae can be isolated from estuarine and aquatic environments. V. cholerae is well recognized and extensively studied as the causative agent of the human intestinal disease cholera. In former centuries cholera was a permanent threat even to the highly developed populations of Europe, North America, and the northern part of Asia. Today, cholera still remains a burden mainly for underdeveloped countries, which cannot afford to establish or to maintain necessary hygienic and medical facilities. Especially in these environments, cholera is responsible for significant mortality and economic damage. During the last three decades, intensive research has been undertaken to unravel the virulence properties and to study the epidemiology of this significant human pathogen. More recently, researchers have been elucidating the environmental lifestyle of V. cholerae. This review provides an overview of the current knowledge of both the host- and environment-specific physiological attributes of V. cholerae.

Comparative genomics reveals mechanism for short-term and long-term clonal transitions in pandemic Vibrio cholerae.

Abstract: Vibrio cholerae, the causative agent of cholera, is a bacterium autochthonous to the aquatic environment, and a serious public health threat. V. cholerae serogroup O1 is responsible for the previous two cholera pandemics, in which classical and El Tor biotypes were dominant in the sixth and the current seventh pandemics, respectively. Cholera researchers continually face newly emerging and reemerging pathogenic clones carrying diverse combinations of phenotypic and genotypic properties, which significantly hampered control of the disease. To elucidate evolutionary mechanisms governing genetic diversity of pandemic V. cholerae, we compared the genome sequences of 23 V. cholerae strains isolated from a variety of sources over the past 98 years. The genome-based phylogeny revealed 12 distinct V. cholerae lineages, of which one comprises both O1 classical and El Tor biotypes. All seventh pandemic clones share nearly identical gene content. Using analogy to influenza virology, we define the transition from sixth to seventh pandemic strains as a “shift” between pathogenic clones belonging to the same O1 serogroup, but from significantly different phyletic lineages. In contrast, transition among clones during the present pandemic period is characterized as a “drift” between clones, differentiated mainly by varying composition of laterally transferred genomic islands, resulting in emergence of variants, exemplified by V. cholerae O139 and V. cholerae O1 El Tor hybrid clones. Based on the comparative genomics it is concluded that V. cholerae undergoes extensive genetic recombination via lateral gene transfer, and, therefore, genome assortment, not serogroup, should be used to define pathogenic V. cholerae clones.