R
R. C. Mühlbauer
Researcher at University of Bern
Publications - 46
Citations - 3010
R. C. Mühlbauer is an academic researcher from University of Bern. The author has contributed to research in topics: Bone resorption & Resorption. The author has an hindex of 26, co-authored 46 publications receiving 2943 citations.
Papers
More filters
Journal ArticleDOI
Effect of ethane-1-hydroxy-1,1-diphosphonate (EHDP) and dichloromethylene diphosphonate (Cl 2 MDP) on the calcification and resorption of cartilage and bone in the tibial epiphysis and metaphysis of rats.
TL;DR: Young male rats were treated for various periods with several doses of disodium ethane-1-hydroxy-1,1-diphosphonate (EHDP) or disodium dichloromethylene diphosph onate (Cl2MDP) and the effects of treatment on the changes in the thickness, growth and mineralization of proximal growth plate and metaphysis of the tibia were assessed histologically and by micro-radiography.
Journal ArticleDOI
The influence of pyrophosphate, condensed phosphates, phosphonates and other phosphate compounds on the dissolution of hydroxyapatite in vitro and on bone resorption induced by parathyroid hormone in tissue culture and in thyroparathyroidectomised rats.
TL;DR: Phosphonates may provide a model for the effect of endogenous PP1 in bone, and might be of use in elucidating mechanisms of bone formation and resorption and in the therapy of diseases that involve increased resOrption of bone.
Journal ArticleDOI
The Inhibitory Effect of Phosphonates on the Formation of Calcium Phosphate Crystals in vitro and on Aortic and Kidney Calcification in vivo
TL;DR: The most effective inhibitors were methylene diphosphonate (MDP), ethane-1-hydroxy-1: I-diphotonate (EHDP) and diehloromethylene diphotonates (Cl2MDP) as discussed by the authors, which showed some ability to inhibit the calcification of the aortas and kidneys of rats treated with large amounts of vitamin D.
Journal ArticleDOI
BM 21.0955, a potent new bisphosphonate to inhibit bone resorption.
TL;DR: A total of 300 new bisphosphonates were screened for their effect on bone resorption in the rat and 1‐hydroxy‐3‐(methylpentylamino)propylidenebisph phosphonate (BM 21.0955) was selected for detailed investigation, appearing to have great potential for use in human bone disease.
Journal ArticleDOI
The influence of pyrophosphate analogues (diphosphonates) on the precipitation and dissolution of calcium phosphate in vitro and in vivo
TL;DR: The failure of pyrophosphate to affect the calcification of certain tissues e.g. kidney and its failure to act when administered orally was attributed to the fact that pyrophophosphate is rapidly broken down at certain sites within the body, where pyrophatase levels are presumed to be high as discussed by the authors.