Optimization of the dose and route of injection, and characterisation of the time course of carbon tetrachloride-induced hepatotoxicity in the rat.

Background: Several lead compounds have been developed from natural resources as hepatoprotective. The hepatotoxic nature of the drugs, industrial toxins and drug-induced hepatotoxicity has been recognized as the major problem associated with liver diseases. Natural products including herbs have great potential in treating liver disorders. Objective: Botanicals have been used traditionally by herbalists and indigenous healers worldwide for several years for the prevention and treatment of liver disease and clinical research in this century has confirmed the efficacy of several plants in the treatment of liver disease. Many herbs used in several systems of alternative medicines have a long history of traditional use in revitalizing the liver and treating liver dysfunction and disease. Many of these herbs have been evaluated in clinical studies and are now being investigated phytochemically to understand their actions in a better way. Conclusion: An attempt has been made through this article to review the m...

Lead finding from medicinal plants with hepatoprotective potentials.

Many plants possess antioxidant ingredients that provided efficacy by additive or synergistic activities. Present article highlights an antioxidant activity of a red listed medicinal plant Aphanamixis polystachya bark which has a strong astringent power. It is used for the treatment of rheumatism, tumours, liver and spleen diseases. Antioxidant activity of the crude extracts of A. polystachya (bark) were assessed using DPPH and FRAP assays. The alcohol, aqueous methanol and petroleum ether extracts exhibited potent antioxidant activity compared to known antioxidants. Due to its natural origin and potent free-radical scavenging ability A. Polystachya could be used as a potential preventive action taken to improve free radical-mediated diseases.

Free Radical Scavenging (DPPH) and Ferric Reducing Ability (FRAP) of Aphanamixis polystachya (Wall) Parker

In the present study the bark of Aphanamixis polystachya was investigated for its macroscopic, phytochemical and antimicrobial characteristics. The dried stem bark of A. polystachya was successive extracted with petroleum ether, chloroform, alcoholic and hydromethanolic solvents for 48 hours in soxhlet apparatus and solvents from extracts was evaporated under vacuum. All four extracts were subjected to phytochemical investigation and in vitro antimicrobial screening using different bacterial strains in nutrient agar media. For screening of antimicrobial activity, extracts of dried stem bark of A. polystachya was used at the different doses (10, 20, 50 and 100mg/ml) against the kanamycin, which was used as standard antimicrobial agent at the dose of 30mg/ml. The zone of inhibitions indicates that the extracts of dried stem bark of Aphanamixis polystachya showed significant antimicrobial activity as comparison to kanamycin. The Preliminary phytochemical investigation revealed the presence of various phytoconstituents in each extracts. It showed the presence of carbohydrates, glycosides and saponins.

PHARMACOGNOSTIC, PHYTOCHEMICAL AND ANTIMICROBIAL SCREENING OF APHANAMIXIS POLYSTACHYA, AN ENDANGERED MEDICINAL TREE Research Article

The genus Amoora: A phytochemical and pharmacological review.

Antihepatotoxic activity of a resuspended residue of the alcohol extract of Amoora rohituka W & A. (Meliaceae) was studied in rats with hepatic injury induced by carbon tetrachloride. Carbon tetrachloride (1 ml/kg, i.p.) was administered twice a week for 3 weeks and an extract of A. rohituka (50 mg/kg/day) was given orally for the same period. The rats were sacrificed 24 h after the last CC14 challenge. Carbon tetrachloride induced elevations of alkaline phosphatase (ALP), glutamate pyruvate transaminase (CPT), alanine aminotransferase (ALAT), glutamate oxaloacetate transaminase (GOT), aspartate aminotransferase (ASAT) and lactate dehydrogenase (LDH) and total plasma bilirubin concentration as well as depression of total plasma cholesterol concentration were reduced significantly by the concurrent treatment of rats with A. rohituka suspension. Changes in the histological architecture of the liver produced by CC14 where also protected by the administration of A. rohituka suspension. These results i...

https://www.tandfonline.com/doi/pdf/10.1080/09251619708951275

R. K. Sur

Papers

Hepatoprotective effect of amoora rohituka