R. Kalirajan

Bio: R. Kalirajan is an academic researcher from Jagadguru Sri Shivarathreeswara University. The author has contributed to research in topics: Docking (molecular) & Pyrazole. The author has an hindex of 12, co-authored 35 publications receiving 421 citations.

Synthesis and Biological evaluation of some heterocyclic derivatives of Chalcones

Abstract: Some novel heterocyclic derivatives such as Thazines, Oxazines, Isoxazoles and Pyrazoles (Ia-d, IIa-d, IIIa-d) were synthesized from various Chalcones. The synthesized compounds have been characterized by TLC, Elemental analysis, IR and 1 H.NMR Spectroscopy. These compounds were screened for their Anti inflammatory, Anti Bacterial and Anti fungal activities.

Docking Studies, Synthesis, Characterization and Evaluation of Their Antioxidant and Cytotoxic Activities of Some Novel Isoxazole-Substituted 9-Anilinoacridine Derivatives

Abstract: A convenient synthesis of novel isoxazole-substituted 9-anilinoacridine derivatives 5a–j was reported. The compounds were confirmed by physical and analytical data and screened for in vitro antioxidant activity by DPPH method, reducing power assay and total antioxidant capacity method. The cytotoxic activity of the compounds was also studied in HEp-2 cell line. The docking studies of the synthesized compounds were performed towards the key nucleoside dsDNA by using AutoDock vina 4.0 programme. All the isoxazole-substituted compounds have significant activities.

Synthesis and biological evaluation of some schiff bases of (4-(amino) -5- phenyl- 4h-1, 2, 4-triazole- 3- thiol)

Abstract: The basic nucleus 4-(amino)-5-phenyl-l-4H-1,2,4-triazole-3-thiol was prepared by cyclisation of potassium dithiocarbazinate with hydrazine hydrate using water as solvent under reflux condition for 3-4 h. The compound which has been synthesized successfully was subjected to addition reaction with different aldehydes to synthesize Schiff bases. The compounds were confirmed by physical parameters (solubility, melting point), chromatographic methods (TLC) and at last spectroscopic methods (IR, NMR, and Mass). In order to ascertain the pharmaceutical application, the selective pharmacological screening of the derivatives was carried out according to the standard procedures. The compounds were screened for their antianxietic activity by elevated plus maze method, antidepressant activity by forced swim test. Among the synthesized compounds, the Schiff bases of benzaldehyde (5e), furfuraldehyde (5d) and 2,4-dichloro benzaldehyde (5a) showed extremely significant activities. Results indicate that these compounds may be potential candidates for managing CNS disorders. However further studies are required to substantiate the same which are underway in our lab.

Nature is the best source of anticancer drugs: Indexing natural products for their anticancer bioactivity.

Abstract: Cancer is considered one of the primary diseases that cause morbidity and mortality in millions of people worldwide and due to its prevalence, there is undoubtedly an unmet need to discover novel anticancer drugs. However, the traditional process of drug discovery and development is lengthy and expensive, so the application of in silico techniques and optimization algorithms in drug discovery projects can provide a solution, saving time and costs. A set of 617 approved anticancer drugs, constituting the active domain, and a set of 2,892 natural products, constituting the inactive domain, were employed to build predictive models and to index natural products for their anticancer bioactivity. Using the iterative stochastic elimination optimization technique, we obtained a highly discriminative and robust model, with an area under the curve of 0.95. Twelve natural products that scored highly as potential anticancer drug candidates are disclosed. Searching the scientific literature revealed that few of those molecules (Neoechinulin, Colchicine, and Piperolactam) have already been experimentally screened for their anticancer activity and found active. The other phytochemicals await evaluation for their anticancerous activity in wet lab.

Chlorella and Spirulina Microalgae as Sources of Functional Foods, Nutraceuticals, and Food Supplements; an Overview

Abstract: Chlorella nbsp and nbsp Spirulina are the two of the most well known microalgae genus Both microalgae genus have a significant content of proteins vitamins pigments fatty acids sterols among others which make their production application by the food industry quite interesting nbsp Chlorella genus is a eukaryotic microorganism whereas Spirulina genus cyanobacteria is a prokaryotic microorganism The aim of this review was to provide an overview on Chlorella and Spirulina microalgae particularly as an alternative source of functional foods nutraceuticals and food supplements in which the following compound groups were addressed I Long Chain Polyunsaturated Fatty Acids II Phenolic Compounds III Volatile Compounds IV Sterols V Proteins Amino Acids Peptides VI Vitamins VII Polysaccharides VIII Pigments and IX Food Chlorella and Spirulina microalgae and their derivatives are concluded not to be widely commercially exploited However they are remarkable sources of functional foods nutraceuticals and food supplements