R.L. Doherty

Bio: R.L. Doherty is an academic researcher from QIMR Berghofer Medical Research Institute. The author has contributed to research in topics: Arbovirus & Ross River virus. The author has an hindex of 12, co-authored 13 publications receiving 608 citations.

Studies of the epidemiology of arthropod-borne virus infections at Mitchell River Mission, Cape York Peninsula, North Queensland. IV. Arbovirus infections of mosquitoes and mammals, 1967-1969.

Abstract: 19 strains of 6 viruses (Kunjin, Kokobera, MRM3929, Koongol, Kowanyama and MRM3630) were isolated from 40,508 mosquitoes collected on 8 occasions from March 1963 to November 1966, at Mitchell River Mission in Cape York Peninsula, Queensland. Isolation rates were lower than in earlier collections in the same area, varied markedly between years, and were very low in each dry season (October–November) when only 4 strains were isolated, all from Anopheline mosquitoes. One virus isolated, Kowanyama, appears to be unrelated to all agents with which it has been compared; one, MRM3630, is related to but easily distinguishable from Mapputta virus; one, MRM3929, was previously isolated from a bird from the same area, but the isolation reported is the first from mosquitoes. Serological tests of children and domestic fowls gave supporting evidence of the occurrence of infections with Group B arboviruses, and also demonstrated infections with Sindbis and Ross River virus. The findings do not indicate the mode of survival of arboviruses in the markedly seasonal environment in this area.

Segmental necrotising glomerulonephritis with antineutrophil antibody: possible arbovirus aetiology?

Abstract: 1 Doll R. Mortality from lung cancer in asbestos workers. Br J Ind Med 1955;12 :81-6. 2 Knox JF, Doll RS, Hill ID. Cohort analysis of changes in incidence of bronchial carcinoma in a textile asbestos factory. Ann NY Acad Sci 1965;132:526-35. 3 Knox JF, Holmes S, Doll R, Hill ID. Mortality from lung cancer and other causes among workers in an asbestos textile factory. BrJf Ind Med 1968 ;25 :293-303. 4 Peto J, Doll R, Howard SV, Kinlen LJ, Lewinsohn HC. A mortality study among workers in an English asbestos factory. Br 7 Ind Med 1977 ;34:169-73. 5 Peto J. The incidence of pleural mesothelioma in chrysotile asbestos textile workers. In: Wagner JC, ed. Biological effects of mineral fibres. Lyons: International Agency for Research into Cancer, 1980:703-11. (Scientific Publications No 30.) 6 British Occupational Hygiene Society. Hygiene standards for chrysotile asbestos dust. Ann Occup Hyg 1968;11:47-69. 7 Berry G, Gilson JC, Holmes S, Lewinsohn HC, Roach SA. Asbestosis: a study of dose-response relationships in an asbestos factory. Br J Ind Med 1979;36:98-112. 8 Berry G, Lewinsohn HC. Dose-response relationships for asbestosrelated disease: implications for hygiene standards. Part I-morbidity. Ann NY Acad Sci 1979;330:185-94. 9 Peto J. The hygiene standard for chrysotile asbestos. Lancet 1978;i: 484-9. 1 Health and Safety Executive. Asbestos-final report of the advisory committee. Vols 1 and 2. London: HMSO, 1979. 1 Pooley FD, Clark NJ. Quantitative assessment of inorganic fibrous particulates in dust samples with an analytical transmission electron microscope. Ann Occup Hyg 1979;22:253-71. 12 Jones JSP, Pooley FD, Clark NJ, et al. The pathology and mineral content of lungs in cases of mesothelioma in the United Kingdom in 1976. In: Wagner JC, ed. Biological effects of mineral fibres. Lyons: International Agency for Research into Cancer, 1980:187-99. (Scientific Publications No 30.) 13 Wagner JC, Pooley FD, Berry G, et al. A pathological and mineralogical study of asbestos-related deaths in the United Kingdom in 1977. In: Walton WH, ed. Ann Occup Hyg (Inhaled particles V) (in press). lo Jones JSP, Smith PG, Pooley FD, et al. The consequences of exposure to asbestos dust in a wartime gas-mask factory. In: Wagner JC, ed. Biological effects of mineral fibres. Lyons: International Agency for Research into Cancer, 1980:637-53. (Scientific Publications No 30.)

Insect Seasonality: Why?

Abstract: Etude comparative de la duree des differents stades de developpement en fonction des saisons en zone tropicale et en zone temperee

Ross River Virus Transmission, Infection, and Disease: a Cross-Disciplinary Review

Abstract: Ross River virus (RRV) is a fascinating, important arbovirus that is endemic and enzootic in Australia and Papua New Guinea and was epidemic in the South Pacific in 1979 and 1980. Infection with RRV may cause disease in humans, typically presenting as peripheral polyarthralgia or arthritis, sometimes with fever and rash. RRV disease notifications in Australia average 5,000 per year. The first well-described outbreak occurred in 1928. During World War II there were more outbreaks, and the name epidemic polyarthritis was applied. During a 1956 outbreak, epidemic polyarthritis was linked serologically to a group A arbovirus (Alphavirus). The virus was subsequently isolated from Aedes vigilax mosquitoes in 1963 and then from epidemic polyarthritis patients. We review the literature on the evolutionary biology of RRV, immune response to infection, pathogenesis, serologic diagnosis, disease manifestations, the extraordinary variety of vertebrate hosts, mosquito vectors, and transmission cycles, antibody prevalence, epidemiology of asymptomatic and symptomatic human infection, infection risks, and public health impact. RRV arthritis is due to joint infection, and treatment is currently based on empirical anti-inflammatory regimens. Further research on pathogenesis may improve understanding of the natural history of this disease and lead to new treatment strategies. The burden of morbidity is considerable, and the virus could spread to other countries. To justify and design preventive programs, we need accurate data on economic costs and better understanding of transmission and behavioral and environmental risks.

Argasid and nuttalliellid ticks as parasites and vectors

Abstract: Publisher Summary Ticks are highly specialized obligate parasites of a wide variety of terrestrial and flying vertebrates and a few marine snakes and lizards. During the one to several long periods that most tick species spend off the host and on the ground, their survival depends on a delicate interplay among physiological and structural properties and functions and ecological factors. Thus, tick-host and tick-environmental factors are both of paramount importance in understanding the role of the individual tick species as a parasite and a vector. This chapter focuses on ticks and tick-borne diseases and reviews tick structures and physiology. It discusses the tick cuticle; humidity relationships and water balance; sensory basis of feeding behavior, attachment, and feeding (role of the mouthparts, feeding apparatus, salivary gland secretions, and host response); immunological basis of host resistance; blood digestion; ion and water balance during feeding and mechanisms of excretion; reproduction (sperm development, cytogenetics, oogenesis, and oviposition); structure and functions of the circulatory, nervous, and neuroendocrine systems; endocrine mechanisms (effects of insect hormones and their mimics on development and reproduction); pheromone mechanisms; and diapause and biological rhythms.