Author
R.M Dawson
Bio: R.M Dawson is an academic researcher from Defence Science and Technology Organisation. The author has contributed to research in topics: Hepatotoxin & Microcystin-LR. The author has an hindex of 1, co-authored 1 publications receiving 792 citations.
Topics: Hepatotoxin, Microcystin-LR
Papers
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TL;DR: The most effective of these is the antibiotic rifampin (a drug approved for clinical use), which protects mice and rats against microcystin-induced lethality when given prophylactically and, in some cases, therapeutically.
823 citations
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TL;DR: In this article, a global assessment of the effects of inorganic nitrogen pollution in aquatic ecosystems is presented, with detailed multi-scale data, and three major environmental problems: (1) increasing the concentration of hydrogen ions in freshwater ecosystems without much acid-neutralizing capacity, resulting in acidification of those systems; (2) stimulating or enhancing the development, maintenance and proliferation of primary producers, leading to eutrophication of aquatic ecosystems; (3) reaching toxic levels that impair the ability of aquatic animals to survive, grow and reproduce.
1,753 citations
TL;DR: The Effects of Harmful Algal Blooms on Aquatic Organisms: Vol. 10, No. 2, pp. 113-390 as mentioned in this paper was the first publication of this article.
Abstract: (2002). The Effects of Harmful Algal Blooms on Aquatic Organisms. Reviews in Fisheries Science: Vol. 10, No. 2, pp. 113-390.
1,242 citations
TL;DR: The overall structural diversity of cyanobacterial oligopeptides only seemingly suggests an equally high diversity of biosynthetic pathways and respective genes, which implies that non-ribosomal peptide synthetase genes are a very ancient part of the cyanob bacterial genome and presumably have evolved by recombination and duplication events to reach the present structural diversity.
Abstract: Cyanobacterial secondary metabolites have attracted increasing scientific interest due to bioactivity of many compounds in various test systems. Among the known structures, oligopeptides are often found with many congeners sharing conserved substructures, while being highly variable in others. A major part of known oligopeptides are of non-ribosomal origin and can be grouped into classes with conserved structural properties. Thus, the overall structural diversity of cyanobacterial oligopeptides only seemingly suggests an equally high diversity of biosynthetic pathways and respective genes. For each class of peptides, some of which have been found in all major branches of the cyanobacterial evolutionary tree, homologous synthetases and genes can be inferred. This implies that non-ribosomal peptide synthetase genes are a very ancient part of the cyanobacterial genome and presumably have evolved by recombination and duplication events to reach the present structural diversity of cyanobacterial oligopeptides. In addition, peptide synthetases would appear to be an essential part of the cyanobacterial evolution and physiology. The present review presents an overview of the biosynthesis of cyanobacterial peptides and corresponding gene clusters, the structural diversity of structural types and structural variations within peptide classes, and implications for the evolution and plasticity of biosynthetic genes and the potential function of cyanobacterial peptides.
706 citations
TL;DR: This paper provides a state of the art on the occurrence and management of harmful cyanobacterial blooms in surface and drinking water, including economic impacts and research needs.
684 citations
TL;DR: With the increasing number of new microcystin variants discovered, the development of new rapid, inexpensive and sensitive enough monitoring methods to promptly screen simultaneously a great diversity of toxins and also check their toxic effects is becoming necessary.
510 citations