R. Mant

TL;DR: A locus segregating with familial Alzheimer's disease (AD) has been mapped to chromosome 21, close to the amyloid precursor protein (APP) gene as discussed by the authors, which suggests that some cases of AD could be caused by mutations in the APP gene.

TL;DR: Data is reported from two independent studies of a BalI polymorphism in the dopamine D3 receptor gene in patients with schizophrenia that more patients than controls were homozygous, and this difference was highly significant.

TL;DR: The findings suggest that the effect is consistently at its strongest in those patients who have a high familial loading and in those who has a good response to neuroleptic treatment, and that differences between the two samples might have contributed to the quantitatively different outcomes.

TL;DR: A linkage study of chromosome 4p markers in a sample of 24 multiply affected families with schizophrenia and related disorders obtained an overall maximum lod of 1.12 with D4S403 under both dominant and recessive modes of transmission, with no statistical support for heterogeneity within the authors' sample.

TL;DR: The results suggest that most of the region can be excluded from containing a gene of major effect in the aetiology of this disease.