Author
R. P. Linstead
Other affiliations: Royal Institution
Bio: R. P. Linstead is an academic researcher from Imperial College London. The author has contributed to research in topics: Dehydrogenation & Transfer hydrogenation. The author has an hindex of 11, co-authored 15 publications receiving 374 citations. Previous affiliations of R. P. Linstead include Royal Institution.
Topics: Dehydrogenation, Transfer hydrogenation, Cryo-adsorption, Nitro, Quinone
Papers
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63 citations
58 citations
45 citations
32 citations
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TL;DR: The present paper reviews phthalocyanine pre-clinical anti-cancer research with emphasis on phthalcyanine induced apoptosis using a silicon phthalicyanine, Pc4, and a brief summary of the latest clinical results using phthalOCyanines is presented.
Abstract: Photodynamic therapy is a binary treatment now accepted in clinic for various malignancies in several countries around the world. Phthalocyanine molecules are second-generation photosensitizers with enhanced photophysical and photochemical properties over those of porphyrins. They have been shown to be phototoxic against a number of cell types and tumor models. A great deal of research has been devoted to the elucidation of their mechanism of action and mode of cell death. The present paper reviews phthalocyanine pre-clinical anti-cancer research with emphasis on phthalocyanine induced apoptosis using a silicon phthalocyanine, Pc4. A brief summary of the latest clinical results using phthalocyanines is presented.
508 citations
TL;DR: In this paper, the same type of studies have been carried out using metallophthalocyanine as the electroactive (semiconductive) part of a field effect transistor (FET).
418 citations
01 Jan 1975
TL;DR: The processes of humification occur mainly under aerobic conditions as mentioned in this paper, where animals that live in the soil may initially reduce the size of the fresh organic residues, and further transformations are promoted by the activity of the enzymes of the bacteria and fungi living in soil.
Abstract: The processes of humification occur mainly under aerobic conditions. Animals that live in the soil may initially reduce the size of the fresh organic residues. Further transformations are promoted by the activity of the enzymes of bacteria and fungi living in the soil. Cellulose, proteins and fats are readily available carbon sources for the microorganisms, whereas such compounds as lignin and other phenolic plant constituents are decomposed more slowly. These, as well as some of the new substances that are formed through oxidation of phenolic units, are toxic to different degrees. They can therefore serve as carbon sources only for special species of microorganisms. Besides the organic residue derived from higher animals and plants, many substances synthesized by microorganisms can serve as carbon sources.
406 citations
TL;DR: The ultraviolet absorption spectra of a number of nucleic acid derivaties (pyrimidines) and related compounds have been measured at various pH values and the variation of the spectra is shown in all cases to be explicable on the basis of ionic dissociation.
360 citations
TL;DR: Methods of aerobic degradation of aromatic compounds in the biosphere are well understood but it is only relatively recently that it has been shown how some bacteria can also degrade these substrates in the absence of molecular oxygen.
Abstract: Methods of aerobic degradation of aromatic compounds in the biosphere are well understood, but it is only relatively recently that it has been shown how some bacteria can also degrade these substrates in the absence of molecular oxygen. This occurs by photometabolism (Athiorhodaceae), nitrate respiration (Pseudomonas and Moraxella sp.) and methanogenic fermentation (a consortium) in which the benzene nucleus is first reduced and then cleaved by hydrolysis to yield aliphatic acids for cell growth. These methods may be used by microbial communities to catabolise man-made pollutants.
292 citations