R
R. Rajasekaran
Researcher at VIT University
Publications - 71
Citations - 931
R. Rajasekaran is an academic researcher from VIT University. The author has contributed to research in topics: Mutant & Single-nucleotide polymorphism. The author has an hindex of 15, co-authored 69 publications receiving 758 citations. Previous affiliations of R. Rajasekaran include Department of Biotechnology.
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Journal ArticleDOI
Identification and in silico analysis of functional SNPs of the BRCA1 gene.
TL;DR: It is proposed that an nsSNP (rs1800751) could be an important candidate for the breast cancer caused by the BRCA1 gene from a comparison of the stabilizing residues of the native and mutant proteins.
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A novel computational and structural analysis of nsSNPs in CFTR gene.
C. George Priya Doss,R. Rajasekaran,C. Sudandiradoss,K. Ramanathan,Rituraj Purohit,Rao Sethumadhavan +5 more
TL;DR: The genetic variations that can alter the expression and function of the CFTR gene responsible for causing cystic fibrosis are analyzed using computational methods to identify potential candidates for future studies on CFTR mutations.
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Applications of computational algorithm tools to identify functional SNPs
C. George Priya Doss,C. Sudandiradoss,R. Rajasekaran,Parikshit Choudhury,Priyanka Sinha,Pragnya Hota,Udit Prakash Batra,Sethumadhavan Rao +7 more
TL;DR: This work analyzed the SNPs that can alter the expression and function of transcriptional factor TP53 as a pipeline and proposed modeled structure for the mutant proteins and compared them with the native protein.
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Computational investigation of curcumin, a natural polyphenol that inhibits the destabilization and the aggregation of human SOD1 mutant (Ala4Val)
E. Srinivasan,R. Rajasekaran +1 more
TL;DR: The study postulated a classical treatment against mutant SOD1, using the naturally occurring polyphenol (curcumin) via the computational framework for designing therapeutics against ALS, and suggested that curcumin showed an enhanced binding affinity in the mutant Sod1 with increased hydrophobic interactions as compared to native S OD1.
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Computational and structural investigation of deleterious functional SNPs in breast cancer BRCA2 gene.
R. Rajasekaran,George Priya Doss,C. Sudandiradoss,K. Ramanathan,Purohit Rituraj,Rao Sethumadhavan +5 more
TL;DR: It is proposed that this most deleterious nsSNP with an SNPid rs28897759 is an important candidate for the cause of breast cancer by BRCA2 gene.