R
R. Scott Hoerrner
Researcher at Merck & Co.
Publications - 24
Citations - 847
R. Scott Hoerrner is an academic researcher from Merck & Co.. The author has contributed to research in topics: Catalysis & Aryl. The author has an hindex of 12, co-authored 24 publications receiving 807 citations. Previous affiliations of R. Scott Hoerrner include University of Delaware.
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Journal ArticleDOI
An improved protocol for the preparation of 3-pyridyl- and some arylboronic acids.
Wenjie Li,Dorian P. Nelson,Mark S. Jensen,R. Scott Hoerrner,Dongwei Cai,Robert D. Larsen,Paul J. Reider +6 more
TL;DR: 3-Pyridylboronic acid was prepared in high yield and bulk quantity from 3-bromopyridine via a protocol of lithium-halogen exchange and "in situ quench", and this technique was further studied and evaluated on other aryl halides in the preparation of aRYlboronic acids.
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Iodine as a chemoselective reoxidant of TEMPO: application to the oxidation of alcohols to aldehydes and ketones.
TL;DR: Iodine was compared to other positive halogens as the terminal oxidant and shown to be superior in cases of electron-rich and heteroaromatic rings and successfully applied to an important intermediate in the synthesis of Losartan.
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Palladium-Catalyzed Regioselective Arylation of Imidazo[1,2-a]pyrimidine
Wenjie Li,Dorian P. Nelson,Mark S. Jensen,R. Scott Hoerrner,Gary Javadi,Dongwei Cai,Robert D. Larsen +6 more
TL;DR: This work has reported an efficient one-step synthesis of 3-arylimidazo[1,2-a]pyrimidines from the unsubstituted heterocycle with a catalytic amount of palladium.
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Enantioselective rhodium-mediated synthesis of (-)-PGE2 methyl ester
Journal ArticleDOI
Convergent, Kilogram Scale Synthesis of an Akt Kinase Inhibitor
Pintipa Grongsaard,Paul G. Bulger,Debra J. Wallace,Lushi Tan,Qinghao Chen,Sarah J. Dolman,Jason L. Nyrop,R. Scott Hoerrner,Mark Weisel,Juan D. Arredondo,Takahiro Itoh,Chengfu Xie,Xianghui Wen,Dalian Zhao,Daniel J. Muzzio,Ephraim M. Bassan,C. Scott Shultz +16 more
TL;DR: The development of a convergent, chromatography-free synthesis of an allosteric Akt kinase inhibitor is described, and improved reaction yield and practicality were achieved in the continuous processing mode.