Author
R.W. Horne
Bio: R.W. Horne is an academic researcher from Medical Research Council. The author has contributed to research in topics: Tobacco mosaic virus & Microscopy. The author has an hindex of 1, co-authored 1 publications receiving 1367 citations.
Papers
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TL;DR: A simple technique has been developed for the study of the external form and structure of virus particles by mixing virus preparations with 1% phosphotungstic acid adjusted to pH 7.5 and spraying directly onto electron microscope supporting films made from evaporated carbon.
1,389 citations
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Book•
01 Jan 1988
TL;DR: The author worked for the smallpox eradi-cation programme in western Africa in 1962-1963 as a member of the staff of the W H O Regional Office for Africa, and joined the Smallpox Eradication unit, of which he was Chief from 1977 until 1984.
Abstract: worked for the smallpox eradi-cation programme in western Africa in 1962-1963 as a member of the staff of the W H O Regional Office for Africa. In 1964 he was transferred t o W H O Headquarters in Geneva, and in 1966 he joined the Smallpox Eradication unit, of which he was Chief from 1977 until 1984. He is now Director of the Kumamoto National Hospital in Japan and a member of the advisory group on international health of the Ministry of Health and Welfare of Japan. while at the Communicable Disease Center in the USA, was responsible in 1965-1 966 for the planning of the western and central African smallpox eradication-measles control programme, conducted with the support of the United States Agency for International Development. USSR from 1983 until his death in 1987. T h e authors alone are responsible for t h e views expressed i n t h i s publication. The World Health Organization welcomes such applications. The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the Secretariat of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. The mention of specific companies or of certain manufacturers' products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters.
1,815 citations
TL;DR: The results obtained show that the filaments are structurally polarized, and in muscle are arranged so that all of them attached on one side of a given Z-line point in one direction, whilst those on the other are oppositely oriented.
1,432 citations
845 citations
TL;DR: The recent advances in electron detection and image processing are reviewed and the exciting new opportunities that they offer to structural biology research are illustrated.
738 citations
TL;DR: Convergent evolution is visible in the morphology of certain phage groups, and most virions are tailed.
Abstract: "Phages" include viruses of eubacteria and archaea. At least 5568 phages have been examined in the electron microscope since the introduction of negative staining in 1959. Most virions (96%) are tailed. Only 208 phages (3.7%) are polyhedral, filamentous, or pleomorphic. Phages belong to one order, 17 families, and three "floating" groups. Phages are found in 11 eubacterial and archaeal phyla and infect 154 host genera, mostly of the phyla Actinobacteria, Firmicutes, and Proteobacteria. Of the tailed phages, 61% have long, noncontractile tails and belong to the family Siphoviridae. Convergent evolution is visible in the morphology of certain phage groups.
630 citations