R
Rachel D. Melamed
Researcher at University of Chicago
Publications - 22
Citations - 3411
Rachel D. Melamed is an academic researcher from University of Chicago. The author has contributed to research in topics: Health care & Medicine. The author has an hindex of 12, co-authored 17 publications receiving 3051 citations. Previous affiliations of Rachel D. Melamed include Columbia University Medical Center & Brigham and Women's Hospital.
Papers
More filters
Journal ArticleDOI
Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum
Sean C. Bendall,Erin F. Simonds,Peng Qiu,El-ad David Amir,Peter O. Krutzik,Rachel Finck,Robert V. Bruggner,Rachel D. Melamed,Angelica Trejo,Olga Ornatsky,Robert S. Balderas,Sylvia K. Plevritis,Karen Sachs,Dana Pe'er,Scott D. Tanner,Garry P. Nolan +15 more
TL;DR: Single-cell “mass cytometry” analyses provide system-wide views of immune signaling in healthy human hematopoiesis, against which drug action and disease can be compared for mechanistic studies and pharmacologic intervention.
Journal ArticleDOI
Foxp3 Transcription-Factor-Dependent and -Independent Regulation of the Regulatory T Cell Transcriptional Signature
Jonathan A. Hill,Markus Feuerer,Kaley Tash,Sokol Haxhinasto,Jasmine Perez,Rachel D. Melamed,Diane Mathis,Christophe Benoist +7 more
TL;DR: A cross-sectional analysis of the Treg cell signature in Treg-like cells generated under a number of conditions is performed to delineate the elements that can be ascribed to T cell activation, interleukin-2, transforming growth factor-beta (TGF-beta) signaling, or Foxp3 itself.
Journal ArticleDOI
A Nondegenerate Code of Deleterious Variants in Mendelian Loci Contributes to Complex Disease Risk
David R. Blair,Christopher S. Lyttle,Jonathan M. Mortensen,Charles F. Bearden,Anders Boeck Jensen,Hossein Khiabanian,Rachel D. Melamed,Raul Rabadan,Elmer V. Bernstam,Søren Brunak,Søren Brunak,Lars Juhl Jensen,Lars Juhl Jensen,Dan L. Nicolae,Nigam H. Shah,Robert L. Grossman,Nancy J. Cox,Kevin P. White,Andrey Rzhetsky +18 more
TL;DR: Using genome-wide association results, it is demonstrated that common variants associated with complex diseases are enriched in the genes indicated by this "Mendelian code," illustrating a complementary approach for mapping complex disease loci and providing unique predictions concerning the etiologies of specific diseases.
Journal ArticleDOI
Sustained antigen presentation can promote an immunogenic T cell response, like dendritic cell activation
Reinhard Obst,Hisse-Martien van Santen,Rachel D. Melamed,Alice O. Kamphorst,Christophe Benoist,Diane Mathis +5 more
TL;DR: It is shown that either prolonged antigen presentation or DC activation could elicit full expansion, effector cytokine production, and memory-cell differentiation in dendritic cells, suggesting that antigen persistence may be an important discriminator of immunogenic and tolerogenic antigen exposure.
Journal ArticleDOI
FBXW7 Mutations in Melanoma and a New Therapeutic Paradigm
Iraz T. Aydin,Rachel D. Melamed,Sarah J. Adams,Mireia Castillo-Martin,Ahu Demir,Diana Bryk,Georg Brunner,Carlos Cordon-Cardo,Iman Osman,Raul Rabadan,Julide T. Celebi +10 more
TL;DR: Evidence is provided on FBXW7 as a critical tumor suppressor mutated and inactivated in melanoma that results in sustained NOTCH1 activation and renders NOTCH signaling inhibition as a promising therapeutic strategy in this setting.