Radek Gazak

TL;DR: This review critically surveys the literature published mainly within this millennium on the new and emerging applications of silybin (pure, chemically defined substance) and silymarin (flavonoid complex from Silybum marianum - milk thistle seeds).

TL;DR: It is established the importance of the 3-OH and 20-OH groups as H donors, in the presence of the 2,3 double bond and the catechol moiety in the E-ring, respectively, and secondary mechanisms could become more important as the active sites for H atom transfer (HAT) mechanism are much less effective (high BDEs).

TL;DR: The data suggest that estrogenicity of some silymarin constituents should be taken in account as their potential side effect when considered as chemopreventive compounds, and stress the need to study biological activities of purified or synthesized diastereomers of silybin derivatives.

TL;DR: The pivotal role of the 3-OH group in the radical-scavenging activity of 2 was confirmed through the formation of another type of dimer from its selectively methylated derivative.

TL;DR: Two selective acylation methods for sily bin esterification with long-chain fatty acids were developed, yielding a series of silybin 7-O- and 23-O -acyl-derivatives of varying acyl chain lengths that were tested for their antioxidant and anti-influenza virus activities.