Rae-Anne Hardie

TL;DR: It is shown that chemical or shRNA‐mediated inhibition of ASCT2 function in vitro decreases glutamine uptake, cell cycle progression through E2F transcription factors, mTORC1 pathway activation and cell growth, and is therefore a putative therapeutic target in prostate cancer.

TL;DR: Analysis of 14 complete mitochondrial genomes from current and museum specimens, as well as mitochondrial and nuclear SNP markers in 175 animals, suggests that the observed low genetic diversity in today's population preceded the Devil Facial Tumor Disease disease outbreak by at least 100 y.

TL;DR: This article showed that chemical or shRNA-mediated inhibition of ASCT2 function in vitro decreases glutamine uptake, cell cycle progression through E2F transcription factors, mTORC1 pathway activation and cell growth.

TL;DR: The populations of southern Africa provide a unique opportunity to investigate the genomic variability from some of the oldest human lineages to the implications of complex admixture patterns including ancient and recently divergedhuman lineages.

TL;DR: It is shown that increasing FA availability increased intracellular triacylglycerol content in cultured patient-derived tumor explants, LNCaP and C4-2B spheroids, and a range of prostate cancer cells, highlighting for the first-time heterogeneity of lipid metabolism in prostatecancer cells and the potential influence that obesity-associated dyslipidemia or host circulating has on prostate cancer progression.