R
Rafael Fernández
Researcher at University of Seville
Publications - 11
Citations - 1222
Rafael Fernández is an academic researcher from University of Seville. The author has contributed to research in topics: Cyclopentadienyl complex & Ethylenediamine. The author has an hindex of 8, co-authored 11 publications receiving 1135 citations. Previous affiliations of Rafael Fernández include University of Edinburgh & Western General Hospital.
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Journal ArticleDOI
Structure-activity relationships for cytotoxic ruthenium(II) arene complexes containing N,N-, N,O-, and O,O-chelating ligands
Abraha Habtemariam,Michael Melchart,Rafael Fernández,Simon Parsons,Iain D. H. Oswald,Andrew Parkin,Francesca P. A. Fabbiani,James E. Davidson,Alice Dawson,Rhona Aird,Duncan I. Jodrell,Peter J. Sadler +11 more
TL;DR: In this paper, structure-activity relationships for organometallic RuII complexes of the type [(η6-arene)Ru(XY)Cl]Z, where XY is an N,N- (diamine), N,O- (e.g., amino acidate), or O,O − (β-diketonate) chelating ligand, the arene ranges from benzene derivatives to fused polycyclic hydrocarbons, and Z is usually PF6.
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Controlling ligand substitution reactions of organometallic complexes: tuning cancer cell cytotoxicity.
Fuyi Wang,Abraha Habtemariam,E P L van der Geer,Rafael Fernández,Michael Melchart,Robert J. Deeth,Rhona Aird,Sylvie Guichard,Francesca P. A. Fabbiani,P Lozano-Casal,Iain D. H. Oswald,Duncan I. Jodrell,Simon Parsons,Peter J. Sadler +13 more
TL;DR: The ability to tune the chemical reactivity of this class of organometallic ruthenium arene compounds should be useful in optimizing their design as anticancer agents.
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Tuning the Reactivity of Osmium(II) and Ruthenium(II) Arene Complexes under Physiological Conditions
Anna F. A. Peacock,Abraha Habtemariam,Rafael Fernández,Victoria Walland,Francesca P. A. Fabbiani,Simon Parsons,Rhona Aird,Duncan I. Jodrell,Peter J. Sadler +8 more
TL;DR: It is shown that the choice of chelating ligand in Os(II) (and Ru(II)) arene complexes can have a dramatic effect on hydrolysis behavior and nucleobase binding and provides a means of tuning the reactivity and the potential for discovery of anticancer complexes.
Journal ArticleDOI
Use of chelating ligands to tune the reactive site of half-sandwich ruthenium(II)-arene anticancer complexes.
TL;DR: It is shown that the chelating ligand XY in Ru(II) anticancer complexes of the type [Ru(eta6-arene)(XY)Cl]n+ has a major influence on the rate and extent of aquation, the pKa of the aqua adduct, and the rates and selectivity of binding to nucleobases.
Journal ArticleDOI
Bisabolanes from the red alga Laurencia scoparia.
Danilo Davyt,Rafael Fernández,Leopoldo Suescun,Alvaro W. Mombrú,Jenny Saldaña,Laura Domínguez,Mutue T. Fujii,Eduardo Manta +7 more
TL;DR: Single-crystal X-ray crystallography allowed us to confirm the structure of 1 as well as to determine the absolute configuration of all stereocenters, and showed weak in vitro anthelmintic activity against parasitant stage Nippostrongilus brasiliensis.