Rahul Mukerjee

Bio: Rahul Mukerjee is an academic researcher from Indian Institute of Management Calcutta. The author has contributed to research in topics: Frequentist inference & Prior probability. The author has an hindex of 30, co-authored 206 publications receiving 3507 citations. Previous affiliations of Rahul Mukerjee include Siemens & Chiba University.

Optimal factorial designs for cDNA microarray experiments

Abstract: We consider cDNA microarray experiments when the cell populations have a factorial structure, and investigate the problem of their optimal designing under a baseline parametrization where the objects of interest differ from those under the more common orthogonal parametrization. First, analytical results are given for the $2\times 2$ factorial. Since practical applications often involve a more complex factorial structure, we next explore general factorials and obtain a collection of optimal designs in the saturated, that is, most economic, case. This, in turn, is seen to yield an approach for finding optimal or efficient designs in the practically more important nearly saturated cases. Thereafter, the findings are extended to the more intricate situation where the underlying model incorporates dye-coloring effects, and the role of dye-swapping is critically examined.

Some aspects of matching priors

Abstract: Priors for which Bayesian and frequentist inference agree, at least to some order of approximation, are called ’matching priors’, and have been proposed as candidates for noninformative priors in Bayesian inference. We give an overview of the original work of Welch and Peers and some more recent developments.

Optimal fractions of two-level factorials under a baseline parameterization

Abstract: Two-level fractional factorial designs are considered under a baseline parameterization. The criterion of minimum aberration is formulated in this context and optimal designs under this criterion are investigated. The underlying theory and the concept of isomorphism turn out to be significantly different from their counterparts under orthogonal parameterization, and this is reflected in the optimal designs obtained. Copyright 2012, Oxford University Press.

Key predistribution schemes for distributed sensor networks via block designs

Abstract: Key predistribution schemes for distributed sensor networks have received significant attention in the recent literature. In this paper we propose a new construction method for these schemes based on combinations of duals of standard block designs. Our method is a broad spectrum one which works for any intersection threshold. By varying the initial designs, we can generate various schemes and this makes the method quite flexible. We also obtain explicit algebraic expressions for the metrics for local connectivity and resiliency. These schemes are quite efficient with regard to connectivity and resiliency and at the same time they allow a straightforward shared-key discovery.

Randomization-based causal inference from split-plot designs

Abstract: Author(s): Zhao, A; Ding, P; Mukerjee, R; Dasgupta, T | Abstract: Under the potential outcomes framework, we propose a randomization based estimation procedure for causal inference from split-plot designs, with special emphasis on 22 designs that naturally arise in many social, behavioral and biomedical experiments. Point estimators of factorial effects are obtained and their sampling variances are derived in closed form as linear combinations of the between- and within-group covariances of the potential outcomes. Results are compared to those under complete randomization as measures of design efficiency. Conservative estimators of these sampling variances are proposed. Connection of the randomization-based approach to inference based on the linear mixed effects model is explored. Results on sampling variances of point estimators and their estimators are extended to general split-plot designs. The superiority over existing model-based alternatives in frequency coverage properties is reported under a variety of simulation settings for both binary and continuous outcomes.

Bayesian Experimental Design: A Review

Abstract: This paper reviews the literature on Bayesian experimental design. A unified view of this topic is presented, based on a decision-theoretic approach. This framework casts criteria from the Bayesian literature of design as part of a single coherent approach. The decision-theoretic structure incorporates both linear and nonlinear design problems and it suggests possible new directions to the experimental design problem, motivated by the use of new utility functions. We show that, in some special cases of linear design problems, Bayesian solutions change in a sensible way when the prior distribution and the utility function are modified to allow for the specific structure of the experiment. The decision-theoretic approach also gives a mathematical justification for selecting the appropriate optimality criterion.

The Selection of Prior Distributions by Formal Rules

Abstract: Subjectivism has become the dominant philosophical foundation for Bayesian inference. Yet in practice, most Bayesian analyses are performed with so-called “noninformative” priors, that is, priors constructed by some formal rule. We review the plethora of techniques for constructing such priors and discuss some of the practical and philosophical issues that arise when they are used. We give special emphasis to Jeffreys's rules and discuss the evolution of his viewpoint about the interpretation of priors, away from unique representation of ignorance toward the notion that they should be chosen by convention. We conclude that the problems raised by the research on priors chosen by formal rules are serious and may not be dismissed lightly: When sample sizes are small (relative to the number of parameters being estimated), it is dangerous to put faith in any “default” solution; but when asymptotics take over, Jeffreys's rules and their variants remain reasonable choices. We also provide an annotated b...

Design and Analysis of Cross-Over Trials

Abstract: This chapter provides an overview of recent developments in the design and analysis of cross-over trials. We first consider the analysis of the trial that compares two treatments, A and B, over two periods and where the subjects are randomized to the treatment sequences AB and BA. We make the distinction between fixed and random effects models and show how these models can easily be fitted using modern software. Issues with fitting and testing for a difference in carry-over effects are described and the use of baseline measurements is discussed. Simple methods for testing for a treatment difference when the data are binary are also described. Various designs with two or more treatments but with three or four periods are then described and compared. These include the balanced and partially balanced designs for three or more treatments and designs for factorial treatment combinations. Also described are nearly balanced and nearly strongly balanced designs. Random subject-effects models for the designs with two or more treatments are described and methods for analysing non-normal data are also given. The chapter concludes with a description of the use of cross-over designs in the testing of bioequivalence.

Experimental design

Abstract: Maximizing data information requires careful selection, termed design, of the points at which data are observed. Experimental design is reviewed here for broad classes of data collection and analysis problems, including: fractioning techniques based on orthogonal arrays, Latin hypercube designs and their variants for computer experimentation, efficient design for data mining and machine learning applications, and sequential design for active learning. © 2012 Wiley Periodicals, Inc. © 2012 Wiley Periodicals, Inc.

Uniform Design: Theory and Application

Abstract: A uniform design (UD) seeks design points that are uniformly scattered on the domain. It has been popular since 1980. A survey of UD is given in the first portion: The fundamental idea and construction method are presented and discussed and examples are given for illustration. It is shown that UD's have many desirable properties for a wide variety of applications. Furthermore, we use the global optimization algorithm, threshold accepting, to generate UD's with low discrepancy. The relationship between uniformity and orthogonality is investigated. It turns out that most UD's obtained here are indeed orthogonal.