Author
Rahul N. Khurana
Other affiliations: University of Southern California, University of California
Bio: Rahul N. Khurana is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Visual acuity & Macular edema. The author has an hindex of 20, co-authored 85 publications receiving 1331 citations. Previous affiliations of Rahul N. Khurana include University of Southern California & University of California.
Papers published on a yearly basis
Papers
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TL;DR: Ocular findings, including posterior placoid chorioretinitis, are important diagnostic features in the early treatment of tertiary syphilis and neurosyphilis, and ophthalmologists have the opportunity to play a key role in theEarly diagnosis and management of this potentially fatal disease.
157 citations
TL;DR: Absence of lens capsule and prior vitrectomy are risk factors for migration of the DEX implant into the anterior chamber and early removal of the implant may be necessary to minimize the risk of chronic corneal edema.
142 citations
TL;DR: Optical coherence tomography provides consistent pachymetry mapping, whereas Orbscan II significantly underestimates corneal thickness in the presence of central cornea scars.
94 citations
TL;DR: Visual benefits with faricimab given at up to 16-week intervals demonstrates its potential to meaningfully extend the time between treatments with sustained efficacy, thereby reducing treatment burden in patients with nAMD.
85 citations
TL;DR: Robust vision gains and anatomical improvements with faricimab were achieved with adjustable dosing up to every 16 weeks, demonstrating the potential for faricIMab to extend the durability of treatment for patients with diabetic macular oedema.
79 citations
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Journal Article•
TL;DR: In this article, optical coherence tomography is used for high-resolution, noninvasive imaging of the human retina, including the macula and optic nerve head in normal human subjects.
Abstract: Objective: To demonstrate optical coherence tomography for high-resolution, noninvasive imaging of the human retina. Optical coherence tomography is a new imaging technique analogous to ultrasound B scan that can provide cross-sectional images of the retina with micrometer-scale resolution. Design: Survey optical coherence tomographic examination of the retina, including the macula and optic nerve head in normal human subjects. Settings Research laboratory. Participants: Convenience sample of normal human subjects. Main Outcome Measures: Correlation of optical coherence retinal tomographs with known normal retinal anatomy. Results: Optical coherence tomographs can discriminate the cross-sectional morphologic features of the fovea and optic disc, the layered structure of the retina, and normal anatomic variations in retinal and retinal nerve fiber layer thicknesses with 10- μm depth resolution. Conclusion: Optical coherence tomography is a potentially useful technique for high depth resolution, cross-sectional examination of the fundus.
1,409 citations
TL;DR: The notion of "para-inflammation" as a state between frank, overt destructive inflammation and the non-inflammatory removal of dead or dying cells by apoptosis, to the retinal community is introduced.
560 citations
Stanford University1, Rutgers University2, Cleveland Clinic3, University of North Carolina at Chapel Hill4, University of Chicago5, Johns Hopkins University6, Medical College of Wisconsin7, Washington University in St. Louis8, BioMérieux9, Beaumont Hospital10, Dartmouth College11, Brown University12, University of Louisville13, Virginia Commonwealth University14, Mayo Clinic15
TL;DR: This document, developed by both laboratory and clinical experts, provides information on which tests are valuable and in which contexts, and on tests that add little or no value for diagnostic decisions.
Abstract: The critical role of the microbiology laboratory in infectious disease diagnosis calls for a close, positive working relationship between the physician and the microbiologists who provide enormous value to the health care team. This document, developed by both laboratory and clinical experts, provides information on which tests are valuable and in which contexts, and on tests that add little or no value for diagnostic decisions. Sections are divided into anatomic systems, including Bloodstream Infections and Infections of the Cardiovascular System, Central Nervous System Infections, Ocular Infections, Soft Tissue Infections of the Head and Neck, Upper Respiratory Infections, Lower Respiratory Tract infections, Infections of the Gastrointestinal Tract, Intraabdominal Infections, Bone and Joint Infections, Urinary Tract Infections, Genital Infections, and Skin and Soft Tissue Infections; or into etiologic agent groups, including Tickborne Infections, Viral Syndromes, and Blood and Tissue Parasite Infections. Each section contains introductory concepts, a summary of key points, and detailed tables that list suspected agents; the most reliable tests to order; the samples (and volumes) to collect in order of preference; specimen transport devices, procedures, times, and temperatures; and detailed notes on specific issues regarding the test methods, such as when tests are likely to require a specialized laboratory or have prolonged turnaround times. There is redundancy among the tables and sections, as many agents and assay choices overlap. The document is intended to serve as a reference to guide physicians in choosing tests that will aid them to diagnose infectious diseases in their patients.
478 citations
TL;DR: A gene-specific quantitative PCR (QPCR)-based assay for the measurement of DNA damage, using amplification of long DNA targets, which has been used extensively to measure the integrity of both nuclear and mitochondrial genomes exposed to different genotoxins.
Abstract: In this chapter, we describe a gene-specific quantitative PCR (QPCR)-based assay for the measurement of DNA damage, using amplification of long DNA targets. This assay has been used extensively to measure the integrity of both nuclear and mitochondrial genomes exposed to different genotoxins and has proven to be particularly valuable in identifying reactive oxygen species-mediated mitochondrial DNA damage. QPCR can be used to quantify both the formation of DNA damage as well as the kinetics of damage removal. One of the main strengths of the assay is that it permits monitoring the integrity of mtDNA directly from total cellular DNA without the need for isolating mitochondria or a separate step of mitochondrial DNA purification. Here we discuss advantages and limitations of using QPCR to assay DNA damage in mammalian cells. In addition, we give a detailed protocol of the QPCR assay that helps facilitate its successful deployment in any molecular biology laboratory.
355 citations
TL;DR: Enhanced depth imaging optical coherence tomography can be used to evaluate the choroidal involvement in VKH disease in the acute stages and may prove useful in the diagnosis and management of this disease noninvasively.
Abstract: Purpose:To evaluate the subfoveal choroidal thickness in Vogt-Koyanagi-Harada (VKH) disease using enhanced depth imaging optical coherence tomographyMethods:Retrospective observational study Subfoveal choroidal thickness was measured using enhanced depth imaging optical coherence tomography, in wh
342 citations