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Author

Raj Vuppalanchi

Indiana University
Other affiliations: Indiana University – Purdue University Indianapolis, Indiana University Health, Virginia Commonwealth University
Bio: Raj Vuppalanchi is an academic researcher from Indiana University. The author has contributed to research in topics: Nonalcoholic fatty liver disease & Medicine. The author has an hindex of 42, co-authored 168 publications receiving 6208 citations. Previous affiliations of Raj Vuppalanchi include Indiana University – Purdue University Indianapolis & Indiana University Health.
Topics: Nonalcoholic fatty liver disease, Medicine, Cirrhosis, Fatty liver, Liver injury
Papers published on a yearly basis
Papers
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Journal Article•DOI•
Features and outcomes of 899 patients with drug-induced liver injury: The DILIN prospective study

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Naga Chalasani1, Herbert L. Bonkovsky, Robert J. Fontana2, William M. Lee3, Andrew Stolz4, Jayant A. Talwalkar5, K. Rajendar Reddy6, Paul B. Watkins7, Victor J. Navarro8, Huiman X. Barnhart9, Jiezhun Gu9, Jose Serrano10, Jawad Ahmad, Nancy Bach, Meena B. Bansal, Huiman X. Barnhart9, Kimberly L. Beavers, Herbert L. Bonkovsky, Francisco O. Calvo, Charissa Y. Chang, Hari S. Conjeevaram, Gregory E. Conner, Jama M. Darling, Ynto S. de Boer, Douglas T. Dieterich, Frank DiPaola, Francisco A. Durazo, James E. Everhart, Robert J. Fontana2, Marwan Ghabril, David Goldstein, Vani Gopalreddy, Priya Grewal, Paul H. Hayashi, Jay H. Hoofnagle, Neil Kaplowitz, Suthat Liangpunsakul, Steven N. Lichtman, Lawrence Liu, Victor Navarro8, Joseph A. Odin, Simona Rossi, Mark W. Russo, Thomas D. Schiano, Averell H. Sherker, Raj Vuppalanchi, Paul B. Watkins7, Steven Zacks, Amanda Balasco, Kristin Chesney, Audrey Corne, Sherrie Cummings, Gale Groseclose, Alex Hammett, Judy Hooker, Varun Kesar, Sophana Mao, Kenari Marks, Regina McFadden, Yolanda Melgoza, Sherif Mikhail, Susan Milstein, Wendy Morlan, Val Peacock, Nidia Rosado, Tracy Russell, Maricruz Vega, Manisha Verma, Patricia F. Walker, Rachana Yalamanchili, Michelle McClanahan-Crowder, Katherine Galan, Tuan Chau, Kowsalya Ragavan, Hoss Rostami, Carmel Puglisi-Scharenbroich, Rebecca Torrance, Rebekah Van Raaphorst •
Indiana University1, University of Michigan2, University of Texas at Austin3, University of Southern California4, Mayo Clinic5, University of Pennsylvania6, University of North Carolina at Chapel Hill7, Albert Einstein Medical Center8, Duke University9, National Institutes of Health10
01 Jun 2015-Gastroenterology
TL;DR: In this article, the authors present characteristics and subgroup analyses from the first 1257 patients enrolled in the study, and conclude that there are no differences in outcomes of patients with short vs long latency of DILI.

576 citations

Journal Article•DOI•
Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: Selected practical issues in their evaluation and management

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Raj Vuppalanchi1, Naga Chalasani1•
Indiana University1
01 Jan 2009-Hepatology
TL;DR: Health care providers should not only focus on liver disease but also concentrate on aggressively modifying and treating their cardiovascular risk factors.

556 citations

Journal Article•DOI•
Portal chronic inflammation in nonalcoholic fatty liver disease (NAFLD): a histologic marker of advanced NAFLD-Clinicopathologic correlations from the nonalcoholic steatohepatitis clinical research network

[...]

Elizabeth M. Brunt1, David E. Kleiner2, Laura Wilson3, Aynur Unalp3, Cynthia E. Behling4, Joel E. Lavine4, Brent A. Neuschwander-Tetri5, Stephanie H. Abrams6, Diana Arceo6, Denise Espinosa6, Leanel Fairly6, Diane Bringman7, Carol Hawkins7, Yao Chang Liu7, Nicholette Rogers7, Margaret Stager7, Arthur J. McCullough8, Srinivasan Dasarathy8, Kevin Edwards8, Ruth Sargent8, Melissa J. Coffey9, Karen F. Murray9, Melissa Young9, Parvathi Mohan10, Kavita Nair10, Manal F. Abdelmalek11, Anna Mae Diehl11, Marcia R. Gottfried11, Cynthia D. Guy11, Paul G. Killenberg11, Samantha Kwan11, Yi Ping Pan11, Dawn Piercy11, Melissa Smith11, Prajakta Bhimalli12, Naga Chalasani12, Oscar W. Cummings12, Lydia Lee12, Linda Ragozzino12, Raj Vuppalanchi12, Barbara Calabrese3, Debra Peglow3, Ann O. Scheimann3, Michael Torbenson3, Ann Klipsch13, Jean P. Molleston13, Girish Subbarao13, Sarah E. Barlow5, Jose Derdoy5, Joyce Hoffmann5, Debra King5, Joan Siegner5, Susan Stewart5, Brent A. Tetri5, Judy Thompson5, Cynthia Behling4, Manual Celedon4, Lisa Clark4, Janis Durelle4, Tarek Hassanein4, Susana Mendoza4, Jeffrey B. Schwimmer4, Claude B. Sirlin4, Tanya Stein4, Allison Tobin4, Kiran Bambha14, Nathan M. Bass14, Linda D. Ferrell14, Danuta Filipowski14, Raphael B. Merriman14, Mark Pabst14, Monique Rosenthal14, Philip J. Rosenthal14, Tessa Steel14, Sherry Boyett15, Daphne Bryan15, Melissa J. Contos15, Michael Fuchs15, Martin F. Graham15, Amy Jones15, Velimir A. Luketic15, Bimalijit Sandhu15, Arun J. Sanyal15, Carol Sargeant15, Kimberly Selph15, Melanie B. White15, Kris V. Kowdley16, Grace Gyurkey16, Jody Mooney16, James E. Nelson16, Sarah Roberts16, Cheryl Saunders16, Alice Stead16, Chia Wang16, Matthew M. Yeh16, Elizabeth M. Brunt1, D Kleiner2, Gilman D. Grave2, Terry T.-K. Huang2, Edward Doo2, Jay E. Everhart2, Jay H. Hoofnagle2, Patricia R. Robuck2, Leonard B. Seeff2, Patricia Belt3, Fred Brancati3, Jeanne M. Clark3, Ryan Colvin3, Michel Donithan3, Mika Green3, Rosemary Hollick3, Milana Isaacson3, Wana Kim3, Alison Lyndecker3, Laura Miriel3, Alice L. Sternberg3, James Tonascia3, Aynur Unalp-Arida3, Mark L. Van Natta3, Laura A. Wilson3, Katherine P. Yates3 •
Washington University in St. Louis1, National Institutes of Health2, Johns Hopkins University3, University of California, San Diego4, Saint Louis University5, Baylor College of Medicine6, MetroHealth7, Cleveland Clinic8, Boston Children's Hospital9, Children's National Medical Center10, Duke University11, Indiana University12, Riley Hospital for Children13, University of California, San Francisco14, Virginia Commonwealth University15, Virginia Mason Medical Center16
01 Mar 2009-Hepatology
TL;DR: Increased portal CI is associated with many clinical and pathologic features of progressive NAFLD in both adults and children, but not with ALT, autoantibodies, or lobular inflammation.

332 citations

Journal Article•DOI•
Liver Injury From Herbals and Dietary Supplements in the U.S. Drug-Induced Liver Injury Network

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Victor J. Navarro, Huiman X. Barnhart1, Herbert L. Bonkovsky2, Timothy Davern3, Robert J. Fontana4, Lafaine Grant5, K. Rajender Reddy6, Leonard B. Seeff, Jose Serrano7, Averell H. Sherker7, Andrew Stolz7, Jayant A. Talwalkar, Maricruz Vega, Raj Vuppalanchi •
Duke University1, Carolinas Healthcare System2, California Pacific Medical Center3, University of Michigan4, University of Texas at Austin5, University of Pennsylvania6, University of Southern California7
01 Oct 2014-Hepatology
TL;DR: Liver injury from nonbodybuilding H DS is more severe than from bodybuilding HDS or medications, as evidenced by differences in unfavorable outcomes (death and transplantation).

310 citations

Journal Article•DOI•
Selonsertib for patients with bridging fibrosis or compensated cirrhosis due to NASH: Results from randomized phase III STELLAR trials

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Stephen A. Harrison1, Vincent Wai-Sun Wong2, Takeshi Okanoue, Natalie Bzowej, Raj Vuppalanchi3, Ziad Younes, Anita Kohli, Shiv Kumar Sarin, Stephen H. Caldwell4, Naim Alkhouri5, Mitchell L. Shiffman, Marianne Camargo, Georgia Li, Kathryn Kersey, Catherine Jia, Yanni Zhu, C. Stephen Djedjos, G. Mani Subramanian, Robert P. Myers, Nadege Gunn1, Aasim Sheikh, Quentin M. Anstee6, Manuel Romero-Gómez, Michael Trauner7, Zachary Goodman8, Eric Lawitz5, Zobair M. Younossi8, Stellar, Stellar Investigators •
Pinnacle Financial Partners1, The Chinese University of Hong Kong2, Indiana University3, University of Virginia4, University of Texas at Austin5, Newcastle upon Tyne Hospitals NHS Foundation Trust6, Medical University of Vienna7, Inova Fairfax Hospital8
01 Jul 2020-Journal of Hepatology
TL;DR: Although selonsertib led to dose-dependent reductions in hepatic phospho-p38 expression indicative of pharmacodynamic activity, it had no significant effect on liver biochemistry, NITs, progression to cirrhosis, or adjudicated clinical events.

263 citations

Cited by
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Journal Article•DOI•
The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases.

[...]

Naga Chalasani1, Zobair M. Younossi2, Joel E. Lavine3, Michael Charlton4, Kenneth Cusi5, Mary E. Rinella6, Stephen A. Harrison7, Elizabeth M. Brunt8, Arun J. Sanyal9 •
Indiana University1, Inova Fairfax Hospital2, Columbia University3, University of Chicago4, University of Florida5, Northwestern University6, Pinnacle Financial Partners7, Washington University in St. Louis8, Virginia Commonwealth University9
01 Jan 2018-Hepatology
TL;DR: This guidance provides a data-supported approach to the diagnostic, therapeutic, and preventive aspects of NAFLD care.

4,431 citations

Journal Article•DOI•
2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular riskThe Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and European Atherosclerosis Society (EAS)

[...]

François Mach, Colin Baigent, Alberico L. Catapano, Konstantinos C. Koskinas1, Manuela Casula, Lina Badimon1, M. John Chapman, Guy De Backer, Victoria Delgado, Brian A. Ference, Ian D. Graham, Alison Halliday, Ulf Landmesser, Borislava Mihaylova, Terje R. Pedersen, Gabriele Riccardi, Dimitrios J. Richter, Marc S. Sabatine, Marja-Riitta Taskinen, Lale Tokgozoglu, Olov Wiklund, Christian Mueller, Heinz Drexel, Victor Aboyans, Alberto Corsini, Wolfram Doehner, Michel Farnier, Bruna Gigante, Meral Kayıkçıoğlu, Goran Krstacic, Ekaterini Lambrinou, Basil S. Lewis, Josep Masip, Philippe Moulin, Steffen E. Petersen, Anna Sonia Petronio, Massimo F Piepoli, Xavier Pintó, Lorenz Räber, Kausik K. Ray, Željko Reiner, Walter F Riesen, Marco Roffi, Jean-Paul Schmid, Evgeny Shlyakhto, Iain A. Simpson, Erik S.G. Stroes, Isabella Sudano, Alexandros D Tselepis, Margus Viigimaa, Cecile Vindis, Alexander Vonbank, Michal Vrablik, Mislav Vrsalovic, José Luis Zamorano, Jean-Philippe Collet, Stephan Windecker, Veronica Dean, Donna Fitzsimons, Chris P Gale, Diederick E. Grobbee, Sigrun Halvorsen, Gerhard Hindricks, Bernard Iung, Peter Jüni, Hugo A. Katus, Christophe Leclercq, Maddalena Lettino, Béla Merkely, Miguel Sousa-Uva, Rhian M. Touyz, Djamaleddine Nibouche, Parounak H. Zelveian, Peter Siostrzonek, Ruslan Najafov, Philippe van de Borne, Belma Pojskic, Arman Postadzhiyan, Lambros Kypris, Jindřich Špinar, Mogens Lytken Larsen, Hesham Salah Eldin, Timo E. Strandberg, Jean Ferrières, Rusudan Agladze, Ulrich Laufs, Loukianos S. Rallidis, Laszlo Bajnok, Thorbjorn Gudjonsson, Vincent Maher, Yaakov Henkin, Michele Massimo Gulizia, Aisulu Mussagaliyeva, Gani Bajraktari, Alina Kerimkulova, Gustavs Latkovskis, Omar Hamoui, Rimvydas Šlapikas, Laurent Visser, P. Dingli, Victoria Ivanov, Aneta Boskovic, Mbarek Nazzi, Frank L.J. Visseren, Irena Mitevska, Kjetil Retterstøl, Piotr Jankowski, Ricardo Fontes-Carvalho, Dan Gaita, Marat V. Ezhov, Marina Foscoli, Vojislav Giga, Daniel Pella, Zlatko Fras, Leopoldo Pérez de Isla, Emil Hagström, Roger Lehmann, Leila Abid, Oner Ozdogan, Olena Mitchenko, Riyaz S. Patel •
University of Bern1
01 Jan 2020-European Heart Journal

4,069 citations

Journal Article•DOI•
The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association

[...]

Naga Chalasani1, Zobair M. Younossi2, Joel E. Lavine3, Anna Mae Diehl4, Elizabeth M. Brunt5, Kenneth Cusi6, Michael Charlton7, Arun J. Sanyal8 •
Indiana University1, Inova Fairfax Hospital2, Columbia University3, Duke University4, Washington University in St. Louis5, University of Florida6, Mayo Clinic7, Virginia Commonwealth University8
01 Jun 2012-Hepatology
TL;DR: This is a practice guideline for clinicians rather than a review article and interested readers can refer to several comprehensive reviews published recently.

3,212 citations

Journal Article•DOI•
EASL-EASD-EASO Clinical Practice Guidelines for the Management of Non-Alcoholic Fatty Liver Disease

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Giulio Marchesini, Christopher P. Day, Jean-François Dufour, Ali Canbay, Valerio Nobili, Vlad Ratziu, Herbert Tilg, Michael Roden, Amalia Gastaldelli, Hannele Yki-Järvinen, Fritz Schick, Roberto Vettor, Gema Frühbeck, Lisbeth Mathus-Vliegen 
01 May 2016-Journal of Hepatology
TL;DR: The final purpose is to improve patient care and awareness of the importance of NAFLD, and to assist stakeholders in the decision-making process by providing evidence-based data, which also takes into consideration the burden of clinical management for the healthcare system.

3,117 citations

Journal Article•DOI•
2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk

[...]

Alison Halliday1, Colin Baigent1, François Mach2, Borislava Mihaylova1, Borislava Mihaylova3, Brian A. Ference4 •
University of Oxford1, Geneva College2, Queen Mary University of London3, University of Cambridge4
02 Sep 2019-Atherosclerosis
TL;DR: Authors/Task Force Members (François Macha, Colin Baigentb,∗∗,2, Alberico L. Catapanoc), ESC Committee for Practice Guidelines (CPG) (Stephan Windeckeraa), ESC National Cardiac Societies (Djamaleddine Nibouchean, Parounak H. Patelcl)

2,972 citations