R
Rajan Vyas
Researcher at Ohio State University
Publications - 18
Citations - 411
Rajan Vyas is an academic researcher from Ohio State University. The author has contributed to research in topics: DNA polymerase & DNA clamp. The author has an hindex of 10, co-authored 18 publications receiving 326 citations. Previous affiliations of Rajan Vyas include Panjab University, Chandigarh & Case Western Reserve University.
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Journal ArticleDOI
VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington’s disease
Xing Guo,Xiaoyan Sun,Di Hu,Ya Juan Wang,Hisashi Fujioka,Rajan Vyas,Sudha Chakrapani,Amit Joshi,Yu Luo,Daria Mochly-Rosen,Xin Qi +10 more
TL;DR: It is shown that VCP is selectively translocated to the mitochondria, where it is bound to mtHtt in various HD models, and the peptide HV-3 might be a useful tool for developing new therapeutics to treat HD.
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Peptidoglycan biosynthesis machinery: a rich source of drug targets.
TL;DR: This review discusses the mechanistic and structural properties of the PG biosynthetic enzymes and inhibitors developed in the last decade.
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Viewing Human DNA Polymerase β Faithfully and Unfaithfully Bypass an Oxidative Lesion by Time-Dependent Crystallography.
TL;DR: These structures provide the first real-time pictures, to the authors' knowledge, of how a polymerase correctly and incorrectly bypasses a DNA lesion.
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Structural Insights into the Post-Chemistry Steps of Nucleotide Incorporation Catalyzed by a DNA Polymerase.
TL;DR: The structural characterization defines the order of the elusive post-chemistry steps in the canonical mechanism of a DNA polymerase and helps to refine the role of the newly discovered third divalent metal ion forDNA polymerase-catalyzed nucleotide incorporation.
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Structures of native, substrate-bound and inhibited forms of Mycobacterium tuberculosis imidazoleglycerol-phosphate dehydratase.
TL;DR: Both the structural and the kinetic data demonstrate that the inhibitor 3-amino-1,2,4-triazole inhibits IGPD competitively.