Author
Rajendhiran Saritha
Bio: Rajendhiran Saritha is an academic researcher from Department of Biotechnology. The author has contributed to research in topics: Carbazole & Pyrazole. The author has an hindex of 2, co-authored 5 publications receiving 13 citations.
Papers
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TL;DR: The photoactivated 4CzIPN organocatalyst is found to be more efficient for single electron transfer without any organic base for the radical reaction and the carbazole-based photocatalyst with wide redox potential is stable and recyclable for further reaction transformations.
Abstract: Highly regioselective organo photocatalysis of 4CzIPN (1,2,3,5-tetrakis(carbazol-9-yl)-4,6-dicyanobenzene) for the arylation of 2H-indazole is demonstrated. The present synthetic route provides a highly safe and easily accessible aniline precursor as an arylation reagent. The photoactivated 4CzIPN organocatalyst is found to be more efficient for single electron transfer without any organic base for the radical reaction. The carbazole-based photocatalyst (4CzIPN) with wide redox potential is stable and recyclable for further reaction transformations. Many indazole and aniline derivatives were used in the reaction and provided the arylated indazole derivatives in good to excellent yield.
18 citations
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TL;DR: In this article, a pyrazole derivatives were synthesized via nucleophilic attack of enamine from an intermediate on the β-carbon of an amino acrylate via a pyrolytic cleavage at elevated temperature.
13 citations
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TL;DR: The in situ generated EDA complex even in a catalytic amount is found to be efficient for the Single Electron Transfer (SET) process without any photoactivation.
Abstract: A highly regioselective, carbazole based Electron Donor Acceptor (EDA) catalyzed synthesis of biaryl and aryl–heteroaryl compounds is described. Various indole and carbazole derivatives were screened for the Homolytic Aromatic Substitution (HAS) reaction. Tetrahydrocarbazole (THC) was very efficient for the HAS transformation and proceeded via a complex formation between diazonium salt and electron rich tetrahydrocarbazole. The UV-Vis spectroscopy technique has been used to confirm the complex formation. The in situ generated EDA complex even in a catalytic amount is found to be efficient for the Single Electron Transfer (SET) process without any photoactivation. Biaryl compounds, 2-phenylfuran, 2-phenylthiophene, and 2-phenylpyrrole and bioactive compounds such as dantrolene and canagliflozin have been synthesized in moderate to excellent yields.
10 citations
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TL;DR: In this article, an iodine-mediated cascade strategy was developed to synthesize amino pyrazole thioether derivatives in the absence of metals as well as solvents, without the formation of diaryl sulfide and sulfenyl-enaminonitrile with broad substrate scope.
Abstract: We developed an iodine-mediated cascade strategy to synthesize amino pyrazole thioether derivatives (11) in the absence of metals as well as solvents. The present approach provides amino pyrazole thioethers in a highly selective manner without the formation of diaryl sulfide and sulfenyl-enaminonitrile with broad substrate scope. The reactivity of nine sulfenylation sources and synthetic applications of the synthesized compounds have been demonstrated. Thus, the overall iodine-mediated multicomponent reaction (MCR) is more economically feasible, efficient, and environmentally benign.
8 citations
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57 citations
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TL;DR: In this paper , the use of metal-based photocatalysts, organic photoredox catalysts, energy transfer photocatalyst, and electron-donor-acceptor complexes in the functionalization of indazole and pyrazole is discussed.
20 citations
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TL;DR: The photoactivated 4CzIPN organocatalyst is found to be more efficient for single electron transfer without any organic base for the radical reaction and the carbazole-based photocatalyst with wide redox potential is stable and recyclable for further reaction transformations.
Abstract: Highly regioselective organo photocatalysis of 4CzIPN (1,2,3,5-tetrakis(carbazol-9-yl)-4,6-dicyanobenzene) for the arylation of 2H-indazole is demonstrated. The present synthetic route provides a highly safe and easily accessible aniline precursor as an arylation reagent. The photoactivated 4CzIPN organocatalyst is found to be more efficient for single electron transfer without any organic base for the radical reaction. The carbazole-based photocatalyst (4CzIPN) with wide redox potential is stable and recyclable for further reaction transformations. Many indazole and aniline derivatives were used in the reaction and provided the arylated indazole derivatives in good to excellent yield.
18 citations
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TL;DR: A visible-light-driven Rhodamine B-catalyzed transition-metal-free 3-ethoxycarbonylmethylation of 2-aryl-2H-indazoles and imidazo[1,2-a]pyridines using commercially available α-bromoesters was realized in water as mentioned in this paper .
Abstract: A visible-light-driven Rhodamine B-catalyzed transition-metal-free 3-ethoxycarbonylmethylation of 2-aryl-2H-indazoles and imidazo[1,2-a]pyridines (40 examples) using commercially available α-bromoesters was realized in water. This protocol features sustainable, operational simplicity, mild reaction conditions, and...
18 citations
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TL;DR: An unprecedented eco-friendly multi-component domino approach for the synthesis of novel spiroquinazolin-2-(thi)ones and quinolin-(thio)ureas is described in this article.
14 citations