Rajesh Kumar

Bio: Rajesh Kumar is an academic researcher from Himachal Pradesh University. The author has contributed to research in topics: Medicine & Materials science. The author has an hindex of 149, co-authored 4439 publications receiving 140830 citations. Previous affiliations of Rajesh Kumar include Guru Nanak Dev University & Intuitive Surgical.

Adding evidence-based behavioral weight loss strategies to a statewide wellness campaign: a randomized clinical trial

Abstract: Objectives. We determined the efficacy and cost-effectiveness of adding an evidence-based Internet behavioral weight loss intervention alone or combined with optional group sessions to ShapeUp Rhode Island 2011 (SURI), a 3-month statewide wellness campaign.Methods. We randomized participants (n = 230; body mass index = 34.3 ±6.8 kg/m2; 84% female) to the standard SURI program (S) or to 1 of 2 enhanced programs: SURI plus Internet behavioral program (SI) or SI plus optional group sessions (SIG). The primary outcome was weight loss at the end of the 3-month program.Results. Weight losses differed among all 3 conditions (S: 1.1% ±0.9%; SI: 4.2% ±0.6%; SIG: 6.1% ±0.6%; Ps ≤ .04). Both SI and SIG increased the percentage of individuals who achieved a 5% weight loss (SI: 42%; SIG: 54%; S: 7%; Ps < .001). Cost per kilogram of weight loss was similar for S ($39) and SI ($35); both were lower than SIG ($114).Conclusions. Although weight losses were greatest at the end of SURI with optional group sessions, the addi...

Clinical applications of fluorodeoxyglucose--positron emission tomography in the management of malignant melanoma.

Abstract: Purpose of reviewMalignant melanoma is the seventh most common newly diagnosed cancer among Americans. In most cases, melanoma is curable by means of surgical excision if diagnosed in early stages of the disease. The prognosis is linked directly to the initial stage at the time of diagnosis. Early d

Searching for stochastic gravitational waves using data from the two colocated LIGO Hanford detectors

Abstract: Searches for a stochastic gravitational-wave background (SGWB) using terrestrial detectors typically involve cross-correlating data from pairs of detectors. The sensitivity of such cross-correlation analyses depends, among other things, on the separation between the two detectors: the smaller the separation, the better the sensitivity. Hence, a colocated detector pair is more sensitive to a gravitational-wave background than a noncolocated detector pair. However, colocated detectors are also expected to suffer from correlated noise from instrumental and environmental effects that could contaminate the measurement of the background. Hence, methods to identify and mitigate the effects of correlated noise are necessary to achieve the potential increase in sensitivity of colocated detectors. Here we report on the first SGWB analysis using the two LIGO Hanford detectors and address the complications arising from correlated environmental noise. We apply correlated noise identification and mitigation techniques to data taken by the two LIGO Hanford detectors, H1 and H2, during LIGO's fifth science run. At low frequencies, 40-460 Hz, we are unable to sufficiently mitigate the correlated noise to a level where we may confidently measure or bound the stochastic gravitational-wave signal. However, at high frequencies, 460-1000 Hz, these techniques are sufficient to set a 95% confidence level upper limit on the gravitational-wave energy density of Ω(f)<7.7×10-4(f/900Hz)3, which improves on the previous upper limit by a factor of ∼180. In doing so, we demonstrate techniques that will be useful for future searches using advanced detectors, where correlated noise (e.g., from global magnetic fields) may affect even widely separated detectors.

Soil aggregation dynamics and carbon sequestration

Abstract: The quantity and quality of residues determine the formation and stabilization of aggregate structure for soil organic carbon (SOC) sequestration. Plant roots and residues are the primary organic skeleton to enmesh the inorganic particles together and build macro- and microaggregates while sequestering SOC. There are three major organic binding agents of aggregation: temporary (plant roots, fungal hyphae, and bacterial cells), transient (polysaccharides), and persistent (humic compounds and polymers). Conversion of natural ecosystems into agricultural lands for intensive cultivation severely depletes SOC pools. Magnitude of SOC sequestration in the soil system depends on the residence time of SOC in aggregates. Microaggregates are bound to old organic C, whereas macroaggregates contain younger organic material. Many techniques have been used to assess the SOC distribution in aggregates. Classical methods include SOC determination in aggregate fractions by wet and dry sieving of bulk soil. Isotopic methods including the determination of 13C and 14C with mass spectrometry are techniques to quantify the turnover and storage of organic materials in soil aggregates. Other techniques involve the use of computed tomography, X-ray scattering, and X-ray microscopy to examine the internal porosity and interaggregate attributes of macro- and microaggregates. Current state-of-knowledge has not unravelled completely the underlying complex processes involved in the sequestration, stability, dynamics, and residence times of SOC in macro- and microaggregates. There is a need to develop a unique conceptual model of aggregate hierarchy.

A population-based study of metastatic colorectal cancer in individuals aged ≥ 80 years: findings from the South Australian Clinical Registry for Metastatic Colorectal Cancer.

Abstract: BACKGROUND Life expectancy is increasing, and more patients are presenting with cancer at an advanced age (≥80 years) Optimal management for this group of patients has not been well defined METHODS The South Australian Clinical Registry for Metastatic Colorectal Cancer (mCRC) collects data on all patients diagnosed since February 2006 in South Australia The authors examined cancer characteristics, treatments administered, and outcomes for patients aged ≥80 years compared with patients aged <80 years RESULTS Data from 2314 patients were evaluable, and 292% of these patients were aged ≥80 years The majority had moderately differentiated tumors Poorly differentiated tumors were reported in fewer patients aged ≥80 years (201% vs 261%; P < 005) Overall, 281% of patients aged ≥80 years received chemotherapy, and 742% received single-agent fluoropyrimidines as first-line treatment By comparison, 682% of patients aged <80 years received chemotherapy, 743% received combination chemotherapy, and 257% received single-agent fluoropyrimidine as first-line treatment No treatment was received by 382% of patients aged ≥80 years compared with 114% of those aged <80 years Participation in clinical trials was lower in patients aged ≥80 years (2% vs 13%) The median survival was worse for patients aged ≥80 years (82 months vs 192 months; P < 001), and the median survival of patients who received chemotherapy was 190 months for those aged ≥80 years and 223 months for those aged <80 years (P = 139) Patients who did not receive treatment had a poor median survival regardless of age (26 months for patients aged ≥80 years vs 27 months for patients aged <80 years) CONCLUSIONS Patients aged ≥80 years were less likely to receive intervention for their metastatic colorectal cancer and had poorer survival The survival of selected patients aged ≥80 years who received chemotherapy was similar to the survival of those aged <80 years despite the receipt of single-agent therapy Patients aged ≥80 years with metastatic colorectal cancer are less likely to receive intervention for their disease and have poorer survival Survival for selected patients aged ≥80 years who receive chemotherapy is similar to the survival of patients aged <80 years despite the receipt of single-agent therapy Cancer 2013 © 2012 American Cancer Society

I and i

Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality. Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

Fast parallel algorithms for short-range molecular dynamics

Abstract: Three parallel algorithms for classical molecular dynamics are presented. The first assigns each processor a fixed subset of atoms; the second assigns each a fixed subset of inter-atomic forces to compute; the third assigns each a fixed spatial region. The algorithms are suitable for molecular dynamics models which can be difficult to parallelize efficiently—those with short-range forces where the neighbors of each atom change rapidly. They can be implemented on any distributed-memory parallel machine which allows for message-passing of data between independently executing processors. The algorithms are tested on a standard Lennard-Jones benchmark problem for system sizes ranging from 500 to 100,000,000 atoms on several parallel supercomputers--the nCUBE 2, Intel iPSC/860 and Paragon, and Cray T3D. Comparing the results to the fastest reported vectorized Cray Y-MP and C90 algorithm shows that the current generation of parallel machines is competitive with conventional vector supercomputers even for small problems. For large problems, the spatial algorithm achieves parallel efficiencies of 90% and a 1840-node Intel Paragon performs up to 165 faster than a single Cray C9O processor. Trade-offs between the three algorithms and guidelines for adapting them to more complex molecular dynamics simulations are also discussed.

Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary.

Abstract: Chronic obstructive pulmonary disease (COPD) remains a major public health problem. It is the fourth leading cause of chronic morbidity and mortality in the United States, and is projected to rank fifth in 2020 in burden of disease worldwide, according to a study published by the World Bank/World Health Organization. Yet, COPD remains relatively unknown or ignored by the public as well as public health and government officials. In 1998, in an effort to bring more attention to COPD, its management, and its prevention, a committed group of scientists encouraged the U.S. National Heart, Lung, and Blood Institute and the World Health Organization to form the Global Initiative for Chronic Obstructive Lung Disease (GOLD). Among the important objectives of GOLD are to increase awareness of COPD and to help the millions of people who suffer from this disease and die prematurely of it or its complications. The first step in the GOLD program was to prepare a consensus report, Global Strategy for the Diagnosis, Management, and Prevention of COPD, published in 2001. The present, newly revised document follows the same format as the original consensus report, but has been updated to reflect the many publications on COPD that have appeared. GOLD national leaders, a network of international experts, have initiated investigations of the causes and prevalence of COPD in their countries, and developed innovative approaches for the dissemination and implementation of COPD management guidelines. We appreciate the enormous amount of work the GOLD national leaders have done on behalf of their patients with COPD. Despite the achievements in the 5 years since the GOLD report was originally published, considerable additional work is ahead of us if we are to control this major public health problem. The GOLD initiative will continue to bring COPD to the attention of governments, public health officials, health care workers, and the general public, but a concerted effort by all involved in health care will be necessary.

Using Multivariate Statistics

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