Author
Rajesh Kumar Thaper
Bio: Rajesh Kumar Thaper is an academic researcher. The author has an hindex of 2, co-authored 2 publications receiving 602 citations.
Papers
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Agency for Science, Technology and Research1, Indian Institute of Chemical Technology2, Indian Institute of Technology Kharagpur3, Indian Institute of Science Education and Research, Mohali4, Indian Institute of Science5, University of South Florida6, Indian Institute of Technology Delhi7, University of Hyderabad8, Novartis9, Massachusetts Institute of Technology10, University of Michigan11, University of Alabama12, Georgetown University13, Council of Scientific and Industrial Research14, Merck & Co.15, Dr. Reddy's Laboratories16
TL;DR: A discussion of the FDA guidance on regulatory classification of pharmaceutical cocrystals of active pharmaceutical ingredients (APIs) was held in Manesar near Delhi, India, from February 2-4, 2012 as mentioned in this paper.
Abstract: The December 2011 release of a draft United States Food and Drug Administration (FDA) guidance concerning regulatory classification of pharmaceutical cocrystals of active pharmaceutical ingredients (APIs) addressed two matters of topical interest to the crystal engineering and pharmaceutical science communities: (1) a proposed definition of cocrystals; (2) a proposed classification of pharmaceutical cocrystals as dissociable “API-excipient” molecular complexes. The Indo–U.S. Bilateral Meeting sponsored by the Indo–U.S. Science and Technology Forum titled The Evolving Role of Solid State Chemistry in Pharmaceutical Science was held in Manesar near Delhi, India, from February 2–4, 2012. A session of the meeting was devoted to discussion of the FDA guidance draft. The debate generated strong consensus on the need to define cocrystals more broadly and to classify them like salts. It was also concluded that the diversity of API crystal forms makes it difficult to classify solid forms into three categories that...
734 citations
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Agency for Science, Technology and Research1, Indian Institute of Chemical Technology2, Indian Institute of Technology Kharagpur3, Indian Institute of Science Education and Research, Mohali4, Indian Institute of Science5, University of South Florida6, Indian Institute of Science Education and Research, Kolkata7, Indian Institute of Technology Delhi8, University of Hyderabad9, Novartis10, Massachusetts Institute of Technology11, University of Michigan12, University of Alabama13, Georgetown University14, Council of Scientific and Industrial Research15, Dr. Reddy's Laboratories16
19 citations
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TL;DR: This Perspective provides a brief historical introduction to crystal engineering itself and an assessment of the importance and utility of the supramolecular synthon, which is one of the most important concepts in the practical use and implementation of crystal design.
Abstract: How do molecules aggregate in solution, and how do these aggregates consolidate themselves in crystals? What is the relationship between the structure of a molecule and the structure of the crystal it forms? Why do some molecules adopt more than one crystal structure? Why do some crystal structures contain solvent? How does one design a crystal structure with a specified topology of molecules, or a specified coordination of molecules and/or ions, or with a specified property? What are the relationships between crystal structures and properties for molecular crystals? These are some of the questions that are being addressed today by the crystal engineering community, a group that draws from the larger communities of organic, inorganic, and physical chemists, crystallographers, and solid state scientists. This Perspective provides a brief historical introduction to crystal engineering itself and an assessment of the importance and utility of the supramolecular synthon, which is one of the most important concepts in the practical use and implementation of crystal design. It also provides a look to the future from the viewpoint of the author, and indicates some directions in which this field might be moving.
1,148 citations
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TL;DR: Seven recent case studies that illustrate how pharmaceutical cocrystals can improve physicochemical properties and clinical performance of drug substances, including a recently approved drug product based upon an ICC, are presented.
699 citations
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TL;DR: In this review the success of numerous pharmaceutical cocrystals for the improvement of the solubility and dissolution rates of poorly soluble drugs is demonstrated using various examples taken from the literature.
499 citations
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TL;DR: In this paper, a linear relationship between ΔpKa and the probability of proton transfer between acid-base pairs has been derived for crystalline complexes with Δ pKa between −1 and 4.
Abstract: Differences in the predicted aqueous pKa values (ΔpKa) have been calculated for 6465 crystalline complexes containing ionised and non-ionised acid–base pairs in the Cambridge Structural Database A linear relationship between ΔpKa and the probability of proton transfer between acid–base pairs has been derived for crystalline complexes with ΔpKa between −1 and 4 The pKa rule is validated and quantitated
424 citations
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TL;DR: Current research trends in applications of ionic liquids to energy, materials, and medicines are discussed to provide some insight into the directions, motivations, challenges, and successes being achieved with ionic liquid research today.
423 citations