Author
Rajni Jain
Other affiliations: Bharat Institute of Technology
Bio: Rajni Jain is an academic researcher from University of Delhi. The author has contributed to research in topics: Dielectric & Flavones. The author has an hindex of 15, co-authored 32 publications receiving 1488 citations. Previous affiliations of Rajni Jain include Bharat Institute of Technology.
Topics: Dielectric, Flavones, Tantalate, Taxus, Ferroelectricity
Papers
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TL;DR: The secondary metabolites isolated from Piper species for the period 1907 to June 1996 have been reviewed in this paper, where nearly six hundred chemical constituents belonging to different classes of bioactive compounds are listed together with their source(s) and references.
849 citations
TL;DR: In this article, taxonomically classified under the genus Taxus, a number of physiologically active compounds of different classes have been extracted from yew trees, including lignans, flavonoids, steroids and sugar derivatives.
131 citations
TL;DR: In this paper, twelve Piper species were extracted from the stems and leaves of P. manii and β-sitosteryl palmitate was obtained for the first time from P. brachystachyum.
130 citations
TL;DR: It is indicated that among the alkaloids and polyphenolics a number of molecules can inhibit growth and invasion of human mammary cancer cells via selective cytotoxicity.
61 citations
TL;DR: Yew trees, taxonomically classified under the genus Taxus, are sources of a number of physiologically active compounds of different classes.
Abstract: Yew trees, taxonomically classified under the genus Taxus, are sources of a number of physiologically active compounds of different classes. Taxane derivatives with various carbon skeletons, lignans, flavonoids, steroids and sugar derivatives have been isolated from different Taxus species. Compounds isolated from the genus Taxus between 1908 and December 1997 have been comprehensively reviewed.
42 citations
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Journal Article•
TL;DR: Western medicine has not yet used flavonoids therapeutically, even though their safety record is exceptional, and suggestions are made where such possibilities may be worth pursuing.
Abstract: Flavonoids are nearly ubiquitous in plants and are recognized as the pigments responsible for the colors of leaves, especially in autumn. They are rich in seeds, citrus fruits, olive oil, tea, and red wine. They are low molecular weight compounds composed of a three-ring structure with various substitutions. This basic structure is shared by tocopherols (vitamin E). Flavonoids can be subdivided according to the presence of an oxy group at position 4, a double bond between carbon atoms 2 and 3, or a hydroxyl group in position 3 of the C (middle) ring. These characteristics appear to also be required for best activity, especially antioxidant and antiproliferative, in the systems studied. The particular hydroxylation pattern of the B ring of the flavonoles increases their activities, especially in inhibition of mast cell secretion. Certain plants and spices containing flavonoids have been used for thousands of years in traditional Eastern medicine. In spite of the voluminous literature available, however, Western medicine has not yet used flavonoids therapeutically, even though their safety record is exceptional. Suggestions are made where such possibilities may be worth pursuing.
4,663 citations
TL;DR: Some of the recent advances in flavonoid research are reviewed and the role of anthocyanins and flavones in providing stable blue flower colours in the angiosperms is outlined.
3,465 citations
TL;DR: Privileged substructures are believed to achieve this through the mimicry of common protein surface elements that are responsible for binding, such as β- and gamma;-turns.
Abstract: Privileged substructures are of potentially great importance in medicinal chemistry. These scaffolds are characterized by their ability to promiscuously bind to a multitude of receptors through a variety of favorable characteristics. This may include presentation of their substituents in a spatially defined manner and perhaps also the ability to directly bind to the receptor itself, as well as exhibiting promising characteristics to aid bioavailability of the overall molecule. It is believed that some privileged substructures achieve this through the mimicry of common protein surface elements that are responsible for binding, such as β- and gamma;-turns. As a result, these structures represent a promising means by which new lead compounds may be identified.
2,620 citations
TL;DR: Flavonoids are plant pigments that are synthesised from phenylalanine, generally display marvelous colors known from flower petals, mostly emit brilliant fluorescence when they are excited by UV light, and are ubiquitous to green plant cells.
2,424 citations
TL;DR: A major focus of this review is the integration of information from genetic and biochemical studies with the unique insights gained from protein X-ray crystallography and homology modeling, which generated a number of new predictions regarding both the importance and mechanistic role of various amino acid substitutions observed among functionally diverse type III PKS enzymes.
833 citations