R
Rajnish A. Gupta
Researcher at Stanford University
Publications - 29
Citations - 13405
Rajnish A. Gupta is an academic researcher from Stanford University. The author has contributed to research in topics: Receptor & Peroxisome proliferator-activated receptor. The author has an hindex of 24, co-authored 29 publications receiving 12633 citations. Previous affiliations of Rajnish A. Gupta include Vanderbilt University Medical Center & Vanderbilt University.
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Journal ArticleDOI
Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
Rajnish A. Gupta,Nilay Shah,Kevin C. Wang,Jeewon Kim,Hugo M. Horlings,David J. Wong,Miao-Chih Tsai,Tiffany Hung,Pedram Argani,John L. Rinn,Yulei Wang,Pius Brzoska,Benjamin Kong,Rui-Chun Li,Robert B. West,Marc J. van de Vijver,Saraswati Sukumar,Howard Y. Chang +17 more
TL;DR: It is shown that lincRNAs in the HOX loci become systematically dysregulated during breast cancer progression, indicating that l incRNAs have active roles in modulating the cancer epigenome and may be important targets for cancer diagnosis and therapy.
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Cyclooxygenase in biology and disease
Raymond N. DuBois,Steven B. Abramson,Leslie J. Crofford,Rajnish A. Gupta,Lee S. Simon,Leo B A van de Putte,Peter E. Lipsky +6 more
TL;DR: The current understanding of the role of cyclooxygenase‐1 and ‐2 in different physiological situations and disease processes ranging from inflammation to cancer is summarized.
Journal ArticleDOI
A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression
Kevin C. Wang,Yul W. Yang,Bo Liu,Amartya Sanyal,Ryan Corces-Zimmerman,Yong Chen,Bryan R. Lajoie,Angeline Protacio,Ryan A. Flynn,Rajnish A. Gupta,Joanna Wysocka,Ming Lei,Job Dekker,Jill A. Helms,Howard Y. Chang +14 more
TL;DR: OTTIP RNA binds the adaptor protein WDR5 directly and targets WDR 5/MLL complexes across HOXA, driving histone H3 lysine 4 trimethylation and gene transcription.
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Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2
TL;DR: Recent studies in humans indicate that therapy with specific COX-2 inhibitors might be an effective approach to colorectal cancer prevention and treatment.
Journal ArticleDOI
Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARdelta.
Hyunjung Jade Lim,Rajnish A. Gupta,Wen Ge Ma,Bibhash C. Paria,David E. Moller,Jason D. Morrow,Raymond N. DuBois,James M. Trzaskos,Sudhansu K. Dey +8 more
TL;DR: It is demonstrated herein that COX2-derived prostacyclin (PGI2) is the primary PG that is essential for implantation and decidualization, and several lines of evidence suggest that the effects of PGI2 are mediated by its activation of the nuclear hormone receptor PPARdelta, demonstrating the first reported biologic function of this receptor signaling pathway.